Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Magdalena Korczynska"'
Autor:
Sara Calhoun, Magdalena Korczynska, Daniel J Wichelecki, Brian San Francisco, Suwen Zhao, Dmitry A Rodionov, Matthew W Vetting, Nawar F Al-Obaidi, Henry Lin, Matthew J O'Meara, David A Scott, John H Morris, Daniel Russel, Steven C Almo, Andrei L Osterman, John A Gerlt, Matthew P Jacobson, Brian K Shoichet, Andrej Sali
Publikováno v:
eLife, Vol 7 (2018)
The functions of most proteins are yet to be determined. The function of an enzyme is often defined by its interacting partners, including its substrate and product, and its role in larger metabolic networks. Here, we describe a computational method
Externí odkaz:
https://doaj.org/article/fd3b096083a24d889b6a4ac902e9dcb6
Autor:
Allyn T. Londregan, Karlygash Aitmakhanova, James Bennett, Laura J. Byrnes, Daniel P. Canterbury, Xiayun Cheng, Thomas Christott, Jennifer Clemens, Steven B. Coffey, João M. Dias, Matthew S. Dowling, Gillian Farnie, Oleg Fedorov, Kimberly F. Fennell, Vicki Gamble, Carina Gileadi, Charline Giroud, Michael R. Harris, Brett D. Hollingshead, Kilian Huber, Magdalena Korczynska, Kimberly Lapham, Paula M. Loria, Arjun Narayanan, Dafydd R. Owen, Brigitt Raux, Parag V. Sahasrabudhe, Roger B. Ruggeri, Laura Díaz Sáez, Ingrid A. Stock, Benjamin A. Thuma, Andy Tsai, Alison E. Varghese
Publikováno v:
Journal of medicinal chemistry.
A series of small-molecule YEATS4 binders have been discovered as part of an ongoing research effort to generate high-quality probe molecules for emerging and/or challenging epigenetic targets. Analogues such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f200505c5effa14e470509072c0e10b
https://pubmed.ncbi.nlm.nih.gov/36562986
https://pubmed.ncbi.nlm.nih.gov/36562986
Autor:
Mary J. Clark, Brian K. Kobilka, Anne Stößel, Peter Gmeiner, Jake Mahoney, Jonas Kaindl, Roger K. Sunahara, Brian K. Shoichet, Xinyu Xu, Markus Stanek, Daniela Dengler, Rachel A. Matt, Harald Hübner, Magdalena Korczynska, Xiangyu Liu, Kunio Hirata
Publikováno v:
Nature chemical biology, vol 16, iss 7
Nat Chem Biol
Nat Chem Biol
Most drugs acting on G-protein-coupled receptors target the orthosteric binding pocket where the native hormone or neurotransmitter binds. There is much interest in finding allosteric ligands for these targets because they modulate physiologic signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6561fd608c2b2ac5658f241cc9a3e6
https://doi.org/10.1038/s41589-020-0549-2
https://doi.org/10.1038/s41589-020-0549-2
Publikováno v:
ACS chemical biology, vol 13, iss 9
Unrelated ligands, often found in drug discovery campaigns, can bind to the same receptor, even with the same protein residues. To investigate how this might occur, and whether it might be typically possible to find unrelated ligands for the same dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f617518d9fd81703337a743d50f6e6
https://escholarship.org/uc/item/4286b1zt
https://escholarship.org/uc/item/4286b1zt
Autor:
Magdalena, Korczynska, Mary J, Clark, Celine, Valant, Jun, Xu, Ee Von, Moo, Sabine, Albold, Dahlia R, Weiss, Hayarpi, Torosyan, Weijiao, Huang, Andrew C, Kruse, Brent R, Lyda, Lauren T, May, Jo-Anne, Baltos, Patrick M, Sexton, Brian K, Kobilka, Arthur, Christopoulos, Brian K, Shoichet, Roger K, Sunahara
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The orthosteric binding sites of the five muscarinic acetylcholine receptor (mAChR) subtypes are highly conserved, making the development of selective antagonists challenging. The allosteric sites of these receptors are more variable, al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f254ae8318eed68acc861d2d65acc92a
https://pubmed.ncbi.nlm.nih.gov/29453275
https://pubmed.ncbi.nlm.nih.gov/29453275
Autor:
Arthur Christopoulos, Jun Xu, Celine Valant, Weijiao Huang, Hayarpi Torosyan, Patrick M. Sexton, Brian K. Kobilka, Brian K. Shoichet, Andrew C. Kruse, Ee Von Moo, Sabine Albold, Brent R. Lyda, Dahlia R. Weiss, Lauren T. May, Mary J. Clark, Jo-Anne Baltos, Magdalena Korczynska, Roger K. Sunahara
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Subtype-selective antagonists for muscarinic acetylcholine receptors (mAChRs) have long been elusive, owing to the highly conserved orthosteric binding site. However, allosteric sites of these receptors are less conserved, motivating the search for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d66354dd46318cee06fa28f97597360
https://doi.org/10.1073/pnas.1718037115
https://doi.org/10.1073/pnas.1718037115
Autor:
John A. Gerlt, Sara Calhoun, Brian San Francisco, Matthew P. Jacobson, Nawar Al-Obaidi, Suwen Zhao, Dmitry A. Rodionov, Magdalena Korczynska, John H. Morris, David Scott, Henry Lin, Daniel J. Wichelecki, Matthew J. O’Meara, Steven C. Almo, Andrej Sali, Matthew W. Vetting, Brian K. Shoichet, Daniel Russel, Andrei L. Osterman
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
The functions of most proteins are yet to be determined. The function of an enzyme is often defined by its interacting partners, including its substrate and product, and its role in larger metabolic networks. Here, we describe a computational method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a4692f5b8b21edfea218a88b0e6699
https://doi.org/10.7554/elife.31097
https://doi.org/10.7554/elife.31097
Autor:
Sara Calhoun, Magdalena Korczynska, Daniel J Wichelecki, Brian San Francisco, Suwen Zhao, Dmitry A Rodionov, Matthew W Vetting, Nawar F Al-Obaidi, Henry Lin, Matthew J O'Meara, David A Scott, John H Morris, Daniel Russel, Steven C Almo, Andrei L Osterman, John A Gerlt, Matthew P Jacobson, Brian K Shoichet, Andrej Sali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64b9bbcc7bdb171edf236b2cfcfa5a13
https://doi.org/10.7554/elife.31097.026
https://doi.org/10.7554/elife.31097.026
Autor:
Frank M. Raushel, Subramanyam Swaminathan, Tamari Narindoshvili, Stephen K. Burley, Howard J. Williams, J. Michael Sauder, B. Hillerich, Chengfu Xu, Dao Feng Xiang, Siddhesh S. Kamat, Zhening Zhang, Magdalena Korczynska, Peter Kolb, Steven C. Almo, Shawn Chang, Brian K. Shoichet
Publikováno v:
Biochemistry
A novel lactonase from Mycoplasma synoviae 53 (MS53_0025) and Mycoplasma agalactiae PG2 (MAG_6390) was characterized by protein structure determination, molecular docking, gene context analysis, and library screening. The crystal structure of MS53_00
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3688b27bd516d2aaa473d329e4e6ee87
http://europepmc.org/articles/PMC4108184
http://europepmc.org/articles/PMC4108184
Autor:
Udo Oppermann, Carina Gileadi, Noah Younger, Eriko Iwasa, Elisabet Gregori-Puigjané, Samuel B. Pollock, Anthony Tumber, Idelisse Ortiz Torres, T. Krojer, Radosław P. Nowak, Magdalena Korczynska, Daniel D. Le, Brian K. Shoichet, S. Velupillai, Danica Galonić Fujimori
Publikováno v:
Journal of medicinal chemistry, vol 59, iss 4
Development of tool molecules that inhibit Jumonji demethylases allows for the investigation of cancer-associated transcription. While scaffolds such as 2,4-pyridinedicarboxylic acid (2,4-PDCA) are potent inhibitors, they exhibit limited selectivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687aac214c5a94ea3d697dc427e79fcc
https://europepmc.org/articles/PMC5080985/
https://europepmc.org/articles/PMC5080985/