Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Magdalena Karbowniczek"'
Autor:
Aristotelis Astrinidis, Chenggang Li, Erik Y. Zhang, Xueheng Zhao, Shuyang Zhao, Minzhe Guo, Tasnim Olatoke, Ushodaya Mattam, Rong Huang, Alan G. Zhang, Lori Pitstick, Elizabeth J. Kopras, Nishant Gupta, Roman Jandarov, Eric P. Smith, Elizabeth Fugate, Diana Lindquist, Maciej M. Markiewski, Magdalena Karbowniczek, Kathryn A. Wikenheiser-Brokamp, Kenneth D. R. Setchell, Francis X. McCormack, Yan Xu, Jane J. Yu
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Tuberous sclerosis complex (TSC) is characterized by multisystem, low-grade neoplasia involving the lung, kidneys, brain, and heart. Lymphangioleiomyomatosis (LAM) is a progressive pulmonary disease affecting almost exclusively women. TSC and LAM are
Externí odkaz:
https://doaj.org/article/ad95cbd9b11f46108c30b103c315f140
Autor:
Jun-Hung Cho, Bhaumik Patel, Santosh Bonala, Sasikanth Manne, Yan Zhou, Surya K. Vadrevu, Jalpa Patel, Marco Peronaci, Shanawaz Ghouse, Elizabeth P. Henske, Fabrice Roegiers, Krinio Giannikou, David J. Kwiatkowski, Hossein Mansouri, Maciej M. Markiewski, Brandon White, Magdalena Karbowniczek
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Tuberous sclerosis complex (TSC) is a rare genetic condition causing tumours with differentiation abnormalities; however the molecular mechanisms causing these defects are unclear. Here the authors show that Notch cooperates with Rheb to block cell d
Externí odkaz:
https://doaj.org/article/c032945d8d7b42608e09e9eacf6389a4
Publikováno v:
Antibodies, Vol 9, Iss 4, p 67 (2020)
The link of the complement system to angiogenesis has remained circumstantial and speculative for several years. Perhaps the most clinically relevant example of possible involvement of complement in pathological neovascularization is age-related macu
Externí odkaz:
https://doaj.org/article/27b12425a83149c28a3b8443c5b99456
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48720 (2012)
In Drosophila, the pattern of adult pigmentation is initiated during late pupal stages by the production of catecholamines DOPA and dopamine, which are converted to melanin. The pattern and degree of melanin deposition is controlled by the expression
Externí odkaz:
https://doaj.org/article/cee1c2fe74ff4b0d9bddd9f615df0ceb
Autor:
Tasnim Olatoke, Andrew Wagner, Aristotelis Astrinidis, Erik Y. Zhang, Minzhe Guo, Alan G. Zhang, Ushodaya Mattam, Elizabeth J. Kopras, Nishant Gupta, Eric P. Smith, Magdalena Karbowniczek, Maciej M. Markiewski, Kathryn A. Wikenheiser-Brokamp, Jeffrey A. Whitsett, Francis X. McCormack, Yan Xu, Jane J. Yu
Publikováno v:
Science Advances. 9
Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disease that predominantly affects women. LAM cells carry TSC1/TSC2 mutations, causing mTORC1 hyperactivation and uncontrolled cell growth. mTORC1 inhibitors stabilize lung function; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4076d850f73a370969800d55f34e396
https://doi.org/10.1126/sciadv.adf8549
https://doi.org/10.1126/sciadv.adf8549
Autor:
Magdalena Karbowniczek, Maciej M. Markiewski, David J. Kwiatkowski, Elizabeth P. Henske, Aristotelis Astrinidis, Maureen E. Murphy, Che-Pei Kung, Shanawaz Ghouse, Surya Kumari Vadrevu, Sasikanth Manne, Hossein Mansouri, Santosh Bonala, Bhaumik Patel, Jun-Hung Cho
We discovered that 90.3% of patients with angiomyolipomas, lymphangioleiomyomatosis (LAM), and tuberous sclerosis complex (TSC) carry the arginine variant of codon 72 (R72) of TP53 and that R72 increases the risk for angiomyolipoma. R72 transactivate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2504d7afe568d5ea15b0bfa9b8f2c5c2
https://doi.org/10.1158/1541-7786.c.6541179
https://doi.org/10.1158/1541-7786.c.6541179
Autor:
Magdalena Karbowniczek, Maciej M. Markiewski, David J. Kwiatkowski, Elizabeth P. Henske, Aristotelis Astrinidis, Maureen E. Murphy, Che-Pei Kung, Shanawaz Ghouse, Surya Kumari Vadrevu, Sasikanth Manne, Hossein Mansouri, Santosh Bonala, Bhaumik Patel, Jun-Hung Cho
S1. Expression of hamartin and p53 in mice. S2. CRISPR-Cas9 mediated editing of TP53 codon 72 in angiomyolipoma cells and the impact of R72 on Notch/Nodal axis. S3. Overexpression of Nodal in LAM. S4. Overexpression of Nodal in TSC-associated renal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b542d244454e317e19255745e0a968d4
https://doi.org/10.1158/1541-7786.22515768.v1
https://doi.org/10.1158/1541-7786.22515768.v1
Autor:
Maciej M. Markiewski, Magdalena Karbowniczek, Othon Almanza, Wojciech Gorczyca, David P. Fairlie, Sasikanth Manne, Linley Riediger, Clayton Cleveland, Priya Sharma, Sharad K. Sharma, Navin K. Chintala, Surya Kumari Vadrevu
PDF file - 209KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433209b2814aba2b923b2655e0b17b3d
https://doi.org/10.1158/0008-5472.22404069
https://doi.org/10.1158/0008-5472.22404069
Autor:
Maciej M. Markiewski, Magdalena Karbowniczek, Othon Almanza, Wojciech Gorczyca, David P. Fairlie, Sasikanth Manne, Linley Riediger, Clayton Cleveland, Priya Sharma, Sharad K. Sharma, Navin K. Chintala, Surya Kumari Vadrevu
PDF file - 85KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c30130999f0a914aa452ed4e31a33c4
https://doi.org/10.1158/0008-5472.22404075
https://doi.org/10.1158/0008-5472.22404075
Autor:
Maciej M. Markiewski, Magdalena Karbowniczek, Othon Almanza, Wojciech Gorczyca, David P. Fairlie, Sasikanth Manne, Linley Riediger, Clayton Cleveland, Priya Sharma, Sharad K. Sharma, Navin K. Chintala, Surya Kumari Vadrevu
PDF file - 981KB, Liver metastasis, C5aR expression on myeloid, 4T1 and T cells, infiltration of CD8+ T cells and MDSCs in livers of breast tumor-bearing mice (S1). MDSCs infiltrate lungs of breast tumor bearing mice prior to metastases (S2). Complem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e89bf89b860017f07f1d461dfb6bfdc
https://doi.org/10.1158/0008-5472.22404072
https://doi.org/10.1158/0008-5472.22404072