Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Magdalena K Bielecka"'
Autor:
Liku B Tezera, Magdalena K Bielecka, Paul Ogongo, Naomi F Walker, Matthew Ellis, Diana J Garay-Baquero, Kristian Thomas, Michaela T Reichmann, David A Johnston, Katalin Andrea Wilkinson, Mohamed Ahmed, Sanjay Jogai, Suwan N Jayasinghe, Robert J Wilkinson, Salah Mansour, Gareth J Thomas, Christian H Ottensmeier, Alasdair Leslie, Paul T Elkington
Publikováno v:
eLife, Vol 9 (2020)
Previously, we developed a 3-dimensional cell culture model of human tuberculosis (TB) and demonstrated its potential to interrogate the host-pathogen interaction (Tezera et al., 2017a). Here, we use the model to investigate mechanisms whereby immune
Externí odkaz:
https://doaj.org/article/26d53fc70a4d49198d9cbc54c4787117
Autor:
Patience T Brace, Liku B Tezera, Magdalena K Bielecka, Toby Mellows, Diana Garay, Shuye Tian, Lucinda Rand, Justin Green, Sanjay Jogai, Andrew J Steele, Timothy M Millar, Tilman Sanchez-Elsner, Jon S Friedland, Christopher G Proud, Paul T Elkington
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006367 (2017)
Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathways driving inflammatory responses in macrophages have been relatively well described, negative regulatory pathways are less well defined. We hypothesi
Externí odkaz:
https://doaj.org/article/ebe696729b734247b66859eda36251bf
Autor:
Liku B Tezera, Magdalena K Bielecka, Andrew Chancellor, Michaela T Reichmann, Basim Al Shammari, Patience Brace, Alex Batty, Annie Tocheva, Sanjay Jogai, Ben G Marshall, Marc Tebruegge, Suwan N Jayasinghe, Salah Mansour, Paul T Elkington
Publikováno v:
eLife, Vol 6 (2017)
Cell biology differs between traditional cell culture and 3-dimensional (3-D) systems, and is modulated by the extracellular matrix. Experimentation in 3-D presents challenges, especially with virulent pathogens. Mycobacterium tuberculosis (Mtb) kill
Externí odkaz:
https://doaj.org/article/e3dfc8abaaa44c1fa114aabbef91d0a5
Autor:
Magdalena K. Bielecka, Liku B. Tezera, Elena Konstantinopoulou, Nicola Casali, Orestis L. Katsamenis, Ximena Gonzalo, Francis Drobniewski, Paul T. Elkington
Publikováno v:
Cellular Microbiology, Vol 2024 (2024)
Tuberculosis (TB) remains a persistent epidemic, and the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) presents a global healthcare threat. While some new agents have been successfully introduced, innovative technologies to evaluate em
Externí odkaz:
https://doaj.org/article/89c14967b6834cf9913a7b1911ba7af6
Publikováno v:
Antibiotics, Vol 11, Iss 10, p 1274 (2022)
We evaluated a novel physiological 3-D bioelectrospray model of the tuberculosis (TB) granuloma to test the activity of a known anti-TB drug, clofazimine; three carbapenems with potential activity, including one currently used in therapy; and nitazox
Externí odkaz:
https://doaj.org/article/f19490ddd2b046f09bd562a4304630b2
Autor:
Diana J. Garay-Baquero, Cory H. White, Naomi F. Walker, Marc Tebruegge, Hannah F. Schiff, Cesar Ugarte-Gil, Stephen Morris-Jones, Ben G. Marshall, Antigoni Manousopoulou, John Adamson, Andres F. Vallejo, Magdalena K. Bielecka, Robert J. Wilkinson, Liku B. Tezera, Christopher H. Woelk, Spiros D. Garbis, Paul Elkington
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
BACKGROUND Tuberculosis (TB) kills more people than any other infection, and new diagnostic tests to identify active cases are required. We aimed to discover and verify novel markers for TB in nondepleted plasma.METHODS We applied an optimized quanti
Externí odkaz:
https://doaj.org/article/07efd161316b4f0ca6beceee411e2163
Autor:
Vincenzo Torraca, Magdalena K. Bielecka, Margarida C. Gomes, Dominik Brokatzky, Elisabeth M. Busch‐Nentwich, Serge Mostowy
Publikováno v:
Cytoskeleton.
SUMMARYTrained immunity is a long-term memory of innate immune cells, generating an improved response upon re-infection.Shigellais an important human pathogen and inflammatory paradigm for which there is no effective vaccine. Using zebrafish larvae w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6feb805987bf5ab1af7d58deaffdef2
https://doi.org/10.1101/2022.11.03.515069
https://doi.org/10.1101/2022.11.03.515069
Autor:
Hoan Van Ngo, Stevens Robertin, Dominik Brokatzky, Magdalena K. Bielecka, Damián Lobato‐Márquez, Vincenzo Torraca, Serge Mostowy
Apoptosis is a form of regulated cell death essential for tissue homeostasis and embryonic development. Apoptosis also plays a key role during bacterial infection, yet some intracellular bacterial pathogens (such as Shigella flexneri, whose lipopolys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165636492c711f453e614a84b9f21c63
https://researchonline.lshtm.ac.uk/id/eprint/4666893/1/Ngo_etal_2022_Septins-promote-caspase-activity-and.pdf
https://researchonline.lshtm.ac.uk/id/eprint/4666893/1/Ngo_etal_2022_Septins-promote-caspase-activity-and.pdf
Autor:
Spiros D. Garbis, Naomi F. Walker, Paul T. Elkington, Cesar Ugarte-Gil, Liku B. Tezera, Diana J. Garay-Baquero, Hannah F. Schiff, Magdalena K. Bielecka, John H. Adamson, Marc Tebruegge, Andres F. Vallejo, Cory H. White, Ben G. Marshall, Robert J. Wilkinson, Christopher H. Woelk, Stephen Morris-Jones, Antigoni Manousopoulou
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 18 (2020)
JCI Insight, Vol 5, Iss 18 (2020)
BACKGROUND Tuberculosis (TB) kills more people than any other infection, and new diagnostic tests to identify active cases are required. We aimed to discover and verify novel markers for TB in nondepleted plasma. METHODS We applied an optimized quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9090599025ef7e6c2d961bf7c465bfcd
https://eprints.soton.ac.uk/446827/
https://eprints.soton.ac.uk/446827/