Výsledky vyhledávání - "Magdalena Jazurek"

RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context

Autor: Alicja A. Komur, Adam Ciesiolka, Agnieszka Fiszer, Wlodzimierz J. Krzyzosiak, Magdalena Jazurek-Ciesiolka, Martyna Olga Urbanek-Trzeciak

Publikováno v: Journal of molecular biology. 432(24)

Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by a CAG repeat expansion in the ATXN3 gene encoding the ataxin-3 protein. Despite extensive research the exact pathogenic mechanisms of SCA3 are still not unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca8a007206a528c22082dead10b6699
https://pubmed.ncbi.nlm.nih.gov/33157084

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RAN translation of the expanded CAG repeats in the SCA3 disease context

Autor: Alicja A. Komur, Adam Ciesiolka, Martyna Olga Urbanek-Trzeciak, Agnieszka Fiszer, Magdalena Jazurek-Ciesiolka

Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by a CAG repeat expansion in theATXN3gene encoding the ataxin-3 protein. Despite extensive research the exact pathogenic mechanisms of SCA3 are still not understo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510c8a3db4d0e81dea968b21a0bb736b
https://doi.org/10.1101/2020.05.07.082354

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Oleic acid increases the transcriptional activity of FoxO1 by promoting its nuclear translocation and β-catenin binding in pancreatic β-cells

Autor: Justyna Janikiewicz, Pawel Dobrzyn, Anna Dziewulska, Magdalena Jazurek-Ciesiolka, Kamil Kozinski, Agnieszka Dobrzyn

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease. 1865(10)

In the setting of metabolic overload, chronic elevations of free fatty acids in blood and tissues are associated with pancreatic β-cell lipotoxicity and failure. Ultimately, obesity combined with insulin resistance increases the dysfunctional demand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755aed2d3450ed2a81bbc97b4ba70903
https://pubmed.ncbi.nlm.nih.gov/31255704

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Identifying proteins that bind to specific RNAs - focus on simple repeat expansion diseases

Autor: Wlodzimierz J. Krzyzosiak, Adam Ciesiolka, Katarzyna Bilinska, Julia Starega-Roslan, Magdalena Jazurek

Publikováno v: Nucleic Acids Research

RNA-protein complexes play a central role in the regulation of fundamental cellular processes, such as mRNA splicing, localization, translation and degradation. The misregulation of these interactions can cause a variety of human diseases, including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcce1722c215c38e7c73b2fc630c235e
http://europepmc.org/articles/PMC5100574

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I03 Mutant HTT MRNA as therapeutic target in allele-selective cag repeat-directed rnai approach and putative pathogenic agent in hd

Autor: Paweł Joachimiak, Paweł M Świtoński, Emilia Kozlowska, Agata Łużna, Wlodzimierz J. Krzyzosiak, Łukasz Przybył, Magdalena Woźna-Wysocka, Agnieszka Fiszer, Adam Ciesiolka, Magdalena Jazurek-Ciesiolka, Michał Michalak

Publikováno v: Experimental therapeutics – preclinical.

In development of therapeutic strategy for Huntington’s disease (HD) targeting mutation site directly to inhibit selectively the expression of mutant gene is an attractive option. We have previously described CAG repeat-targeting siRNAs with specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2409f0058aa233e6d6d1ec4510a86ea
https://doi.org/10.1136/jnnp-2018-ehdn.239

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Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions

Autor: Wlodzimierz J. Krzyzosiak, Adam Ciesiolka, Magdalena Jazurek, Karolina Drazkowska

Publikováno v: Frontiers in Cellular Neuroscience

Short Tandem Repeats (STRs) are frequent entities in many transcripts, however, in some cases, pathological events occur when a critical repeat length is reached. This phenomenon is observed in various neurological disorders, such as myotonic dystrop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049fff6777640e2f0d7a39407e11e0dd
https://doi.org/10.3389/fncel.2017.00097

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RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders

Autor: Marzena Wojciechowska, Marta Olejniczak, Magdalena Jazurek, Wlodzimierz J. Krzyzosiak, Paulina Galka-Marciniak

Publikováno v: Nucleic Acids Research

Repeat-associated disorders caused by expansions of short sequences have been classified as coding and noncoding and are thought to be caused by protein gain-of-function and RNA gain-of-function mechanisms, respectively. The boundary between such cla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b4f81b072d0f8315632d3701cd1152
http://europepmc.org/articles/PMC4231732

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CB1 Cannabinoid Receptors Couple to Focal Adhesion Kinase to Control Insulin Release

Autor: Vincenzo Di Marzo, Justyna Janikiewicz, Katarzyna Malenczyk, Ken Mackie, Cristoforo Silvestri, Agnieszka Dobrzyn, Tibor Harkany, Maria Jolanta Redowicz, Magdalena Jazurek, Erik Keimpema

Publikováno v: Journal of Biological Chemistry; Vol 288

Endocannabinoid signaling has been implicated in modulating insulin release from β cells of the endocrine pancreas. β Cells express CB1 cannabinoid receptors (CB1Rs), and the enzymatic machinery regulating anandamide and 2-arachidonoylglycerol bioa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f780b119ecd8256f89d25b673ecfaf30

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