Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Magdalena Jazurek"'
Autor:
Marek Napierala, Magdalena Jazurek-Ciesiolka, David A. Lynch, Martyna Olga Urbanek-Trzeciak, Lauren A. Hauser, Anna M. Schreiber, Jill S. Napierala, Julia O. Misiorek
Publikováno v:
Molecular Neurobiology
Friedreich’s ataxia (FRDA) is a genetic neurodegenerative disease that is caused by guanine-adenine-adenine (GAA) nucleotide repeat expansions in the first intron of the frataxin (FXN) gene. Although present in the intron, this mutation leads to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a549edd592f0d7ca974301a1c3249380
https://doi.org/10.1007/s12035-020-01899-1
https://doi.org/10.1007/s12035-020-01899-1
Autor:
Magdalena Jazurek-Ciesiolka, Pawel M. Switonski, Maciej Figiel, Agnieszka Fiszer, Paula Sobieszczanska, Dorota Wronka, Lukasz Przybyl, Joanna Suszynska-Zajczyk, Adam Ciesiolka, Grzegorz Figura, Magdalena Wozna-Wysocka, Julia O. Misiorek, Wlodzimierz J. Krzyzosiak
Publikováno v:
B: Models for HD.
Background Experiments with HD mouse models allow for insight into detailed molecular pathways disrupted in the course of disease development. New aspects of HD pathology need to be determined to bring additional targets and hints for therapeutic app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c049d2af58ea8a860c188df504977dc
https://doi.org/10.1136/jnnp-2021-ehdn.23
https://doi.org/10.1136/jnnp-2021-ehdn.23
Autor:
Alicja A. Komur, Adam Ciesiolka, Agnieszka Fiszer, Wlodzimierz J. Krzyzosiak, Magdalena Jazurek-Ciesiolka, Martyna Olga Urbanek-Trzeciak
Publikováno v:
Journal of molecular biology. 432(24)
Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by a CAG repeat expansion in the ATXN3 gene encoding the ataxin-3 protein. Despite extensive research the exact pathogenic mechanisms of SCA3 are still not unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca8a007206a528c22082dead10b6699
https://pubmed.ncbi.nlm.nih.gov/33157084
https://pubmed.ncbi.nlm.nih.gov/33157084
Autor:
Justyna Janikiewicz, Pawel Dobrzyn, Anna Dziewulska, Magdalena Jazurek-Ciesiolka, Kamil Kozinski, Agnieszka Dobrzyn
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1865(10)
In the setting of metabolic overload, chronic elevations of free fatty acids in blood and tissues are associated with pancreatic β-cell lipotoxicity and failure. Ultimately, obesity combined with insulin resistance increases the dysfunctional demand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755aed2d3450ed2a81bbc97b4ba70903
https://pubmed.ncbi.nlm.nih.gov/31255704
https://pubmed.ncbi.nlm.nih.gov/31255704
Autor:
Wlodzimierz J. Krzyzosiak, Adam Ciesiolka, Katarzyna Bilinska, Julia Starega-Roslan, Magdalena Jazurek
Publikováno v:
Nucleic Acids Research
RNA-protein complexes play a central role in the regulation of fundamental cellular processes, such as mRNA splicing, localization, translation and degradation. The misregulation of these interactions can cause a variety of human diseases, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcce1722c215c38e7c73b2fc630c235e
http://europepmc.org/articles/PMC5100574
http://europepmc.org/articles/PMC5100574
Autor:
Paweł Joachimiak, Paweł M Świtoński, Emilia Kozlowska, Agata Łużna, Wlodzimierz J. Krzyzosiak, Łukasz Przybył, Magdalena Woźna-Wysocka, Agnieszka Fiszer, Adam Ciesiolka, Magdalena Jazurek-Ciesiolka, Michał Michalak
Publikováno v:
Experimental therapeutics – preclinical.
In development of therapeutic strategy for Huntington’s disease (HD) targeting mutation site directly to inhibit selectively the expression of mutant gene is an attractive option. We have previously described CAG repeat-targeting siRNAs with specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2409f0058aa233e6d6d1ec4510a86ea
https://doi.org/10.1136/jnnp-2018-ehdn.239
https://doi.org/10.1136/jnnp-2018-ehdn.239
Publikováno v:
Frontiers in Cellular Neuroscience
Short Tandem Repeats (STRs) are frequent entities in many transcripts, however, in some cases, pathological events occur when a critical repeat length is reached. This phenomenon is observed in various neurological disorders, such as myotonic dystrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049fff6777640e2f0d7a39407e11e0dd
https://doi.org/10.3389/fncel.2017.00097
https://doi.org/10.3389/fncel.2017.00097
Autor:
Marzena Wojciechowska, Marta Olejniczak, Magdalena Jazurek, Wlodzimierz J. Krzyzosiak, Paulina Galka-Marciniak
Publikováno v:
Nucleic Acids Research
Repeat-associated disorders caused by expansions of short sequences have been classified as coding and noncoding and are thought to be caused by protein gain-of-function and RNA gain-of-function mechanisms, respectively. The boundary between such cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b4f81b072d0f8315632d3701cd1152
http://europepmc.org/articles/PMC4231732
http://europepmc.org/articles/PMC4231732
Autor:
Vincenzo Di Marzo, Justyna Janikiewicz, Katarzyna Malenczyk, Ken Mackie, Cristoforo Silvestri, Agnieszka Dobrzyn, Tibor Harkany, Maria Jolanta Redowicz, Magdalena Jazurek, Erik Keimpema
Publikováno v:
Journal of Biological Chemistry; Vol 288
Endocannabinoid signaling has been implicated in modulating insulin release from β cells of the endocrine pancreas. β Cells express CB1 cannabinoid receptors (CB1Rs), and the enzymatic machinery regulating anandamide and 2-arachidonoylglycerol bioa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f780b119ecd8256f89d25b673ecfaf30
Adipose- and muscle-derived Wnts trigger pancreatic β-cell adaptation to systemic insulin resistance
Autor:
Justyna Janikiewicz, Katarzyna Kolczynska, Pawel Dobrzyn, Agnieszka Dobrzyn, Anna Gajda, Kamil Kozinski, Magdalena Jazurek
Publikováno v:
Scientific Reports
Wnt signaling molecules are associated with obesity, hyperlipidemia and type 2 diabetes (T2D). Here, we show that two Wnt proteins, WNT3a and WNT4, are specifically secreted by skeletal muscle and adipose tissue during the development of insulin resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41863a9138d96c875397a3b6b9530486
https://doi.org/10.1038/srep31553
https://doi.org/10.1038/srep31553