Mesenchymal stem/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic osteoarthritis model

Autor: Kelly Warmink, Jaqueline L. Rios, Suzy Varderidou-Minasian, Marta Torres-Torrillas, Devin R. van Valkengoed, Sabine Versteeg, Niels Eijkelkamp, Harrie Weinans, Nicoline M. Korthagen, Magdalena J. Lorenowicz

Publikováno v: Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Background Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute to OA development an

Externí odkaz: https://doaj.org/article/d532f1afff2e414a954dc81b311733ad

Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper

Autor: Thomas Lener, Mario Gimona, Ludwig Aigner, Verena Börger, Edit Buzas, Giovanni Camussi, Nathalie Chaput, Devasis Chatterjee, Felipe A. Court, Hernando A. del Portillo, Lorraine O'Driscoll, Stefano Fais, Juan M. Falcon-Perez, Ursula Felderhoff-Mueser, Lorenzo Fraile, Yong Song Gho, André Görgens, Ramesh C. Gupta, An Hendrix, Dirk M. Hermann, Andrew F. Hill, Fred Hochberg, Peter A. Horn, Dominique de Kleijn, Lambros Kordelas, Boris W. Kramer, Eva-Maria Krämer-Albers, Sandra Laner-Plamberger, Saara Laitinen, Tommaso Leonardi, Magdalena J. Lorenowicz, Sai Kiang Lim, Jan Lötvall, Casey A. Maguire, Antonio Marcilla, Irina Nazarenko, Takahiro Ochiya, Tushar Patel, Shona Pedersen, Gabriella Pocsfalvi, Stefano Pluchino, Peter Quesenberry, Ilona G. Reischl, Francisco J. Rivera, Ralf Sanzenbacher, Katharina Schallmoser, Ineke Slaper-Cortenbach, Dirk Strunk, Torsten Tonn, Pieter Vader, Bas W. M. van Balkom, Marca Wauben, Samir El Andaloussi, Clotilde Théry, Eva Rohde, Bernd Giebel

Publikováno v: Journal of Extracellular Vesicles, Vol 4, Iss 0, Pp 1-31 (2015)

Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different cell types and participate in physiological and pathophysiological processes. EVs mediate intercellular communication as cell-derived extracellular signalling

Externí odkaz: https://doaj.org/article/335c9de0f61146b691d34b6192d90144

Amyotrophic Lateral Sclerosis Proteomic Signature And Treatment With Mesenchymal Stem Cell-derived Extracellular Vesicles

Autor: Suzy Varderidou-Minasian, Svetlana Pasteuning-Vuhman, Annabel Timmers, Maarten Altelaar, Magdalena J Lorenowicz, R Jeroen Pasterkamp

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with a lifetime risk of 1:400, primarily affecting upper and lower motor neurons. Unfortunately, there are only two drugs approved to treat ALS, which increase patient su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80b33f4c98c044b000c80942651f5215
https://doi.org/10.1101/2022.07.05.498816

Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile

Autor: Colin de Haar, Kasper Westinga, Mette D. Hazenberg, Caroline A. Lindemans, Sanne van Dooremalen, Rick Admiraal, Lotte van der Wagen, Jürgen Kuball, Magdalena J. Lorenowicz, Anke Janssen, Jaap Jan Boelens, Walter J.F.M. van der Velden, Febilla Fernando, Nagesha Appukudige, Rien van Marwijk Kooy, Annoek E.C. Broers, Jeroen Janssen, Gerwin Huls, Alberto Miranda-Bedate

Publikováno v: Bone Marrow Transplantation, 55, 2188-2192
Bone Marrow Transplantation, 55(11), 2188-2192. Nature Publishing Group
Bone marrow transplantation, 55(11), 2188-2192. Nature Publishing Group
van der Wagen, L E, Miranda-Bedate, A, Janssen, A, Fernando, F, Appukudige, N, van Dooremalen, S, Westinga, K, Admiraal, R, Lorenowicz, M J, Huls, G, Janssen, J J W M, Broers, A E C, van der Velden, W J F M, van Marwijk Kooy, R, Hazenberg, M D, de Haar, C, Lindemans, C, Jan Boelens, J & Kuball, J 2020, ' Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile ', Bone Marrow Transplantation, vol. 55, no. 11, pp. 2188-2192 . https://doi.org/10.1038/s41409-020-0910-9
Bone Marrow Transplantation, 55, 11, pp. 2188-2192

Contains fulltext : 229413.pdf (Publisher’s version ) (Closed access)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b48fc123a55f88a9f68c16049df95b
http://hdl.handle.net/2066/229413

Mesenchymal stromal/stem cell-derived extracellular vesicles promote human cartilage regeneration in vitro

Autor: Paul J. Coffer, Sanne van Dooremalen, Lucienne A. Vonk, Judith Klumperman, Daniel B.F. Saris, Nalan Liv, Magdalena J. Lorenowicz

Publikováno v: Theranostics, 8(4), 906. Ivyspring International Publisher
Theranostics
Theranostics, 8(4), 906-920. Ivyspring International Publisher

Osteoarthritis (OA) is a rheumatic disease leading to chronic pain and disability with no effective treatment available. Recently, allogeneic human mesenchymal stromal/stem cells (MSC) entered clinical trials as a novel therapy for OA. Increasing evi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01928f10c7ecdceb3dbe4faed4ebc3a4
https://dspace.library.uu.nl/handle/1874/363761