Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Magdalena I. Ivanova"'
Autor:
Samuel D. McCalpin, Lucie Khemtemourian, Saba Suladze, Magdalena I. Ivanova, Bernd Reif, Ayyalusamy Ramamoorthy
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Aggregation of the human islet amyloid polypeptide (hIAPP) contributes to the development and progression of Type 2 Diabetes (T2D). hIAPP aggregates within a few hours at few micromolar concentration in vitro but exists at millimolar concent
Externí odkaz:
https://doaj.org/article/76196303c8fc41bb85c71773c058e15d
Autor:
Shuangcheng Alivia Wu, Chenchen Shen, Xiaoqiong Wei, Xiawei Zhang, Siwen Wang, Xinxin Chen, Mauricio Torres, You Lu, Liangguang Leo Lin, Huilun Helen Wang, Allen H. Hunter, Deyu Fang, Shengyi Sun, Magdalena I. Ivanova, Yi Lin, Ling Qi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Endoplasmic reticulum (ER)-associated degradation (ERAD) and ER-phagy are two principal degradative mechanisms for ER proteins and aggregates, respectively; however, the crosstalk between these two pathways under physiological settings remai
Externí odkaz:
https://doaj.org/article/55b8edfe9e8d440db2033fcd22bb16d0
Autor:
Kelly Z. Young, Carolina Rojas Ramírez, Simon G. Keep, John R. Gatti, Soo Jung Lee, Xiaojie Zhang, Magdalena I. Ivanova, Brandon T. Ruotolo, Michael M. Wang
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Specific cysteine residue alterations and quaternary structures are induced by CADASIL mutations in NOTCH3, which are found to induce oligomeric states, altered disulphide bonding, increased free thiols and reduced protein stability.
Externí odkaz:
https://doaj.org/article/60e1780b1a8f414998df307a93fc4f7e
Autor:
Julia E. Gerson, Hunter Linton, Jiazheng Xing, Alexandra B. Sutter, Fayth S. Kakos, Jaimie Ryou, Nyjerus Liggans, Lisa M. Sharkey, Nathaniel Safren, Henry L. Paulson, Magdalena I. Ivanova
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The brain-expressed ubiquilins, UBQLNs 1, 2 and 4, are highly homologous proteins that participate in multiple aspects of protein homeostasis and are implicated in neurodegenerative diseases. Studies have established that UBQLN2 forms liquid
Externí odkaz:
https://doaj.org/article/fcee382d1ef546399d85f2b4630abc8a
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Aggregation of the protein tau is a pathological hallmark of Alzheimer’s disease (AD) and related disorders. However, the molecular mechanisms that lead to tau protein aggregation are still unclear. Previously, we showed that EFhd2 protein is assoc
Externí odkaz:
https://doaj.org/article/ff3d8c0a23434824b61653467043d0e6
Autor:
Wouter Peelaerts, Gabriela Mercado, Sonia George, Marie Villumsen, Alysa Kasen, Miguel Aguileta, Christian Linstow, Alexandra B. Sutter, Emily Kuhn, Lucas Stetzik, Rachel Sheridan, Liza Bergkvist, Lindsay Meyerdirk, Allison Lindqvist, Martha L. Escobar Gavis, Chris Van den Haute, Scott J. Hultgren, Veerle Baekelandt, J. Andrew Pospisilik, Tomasz Brudek, Susana Aznar, Jennifer A. Steiner, Michael X. Henderson, Lena Brundin, Magdalena I. Ivanova, Tom J. Hannan, Patrik Brundin
Publikováno v:
Acta Neuropathologica. 145:541-559
Symptoms in the urogenital organs are common in multiple system atrophy (MSA), also in the years preceding the MSA diagnosis. It is unknown how MSA is triggered and these observations in prodromal MSA led us to hypothesize that synucleinopathy could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8e06332a93b1806d5f43f520590e9c
https://doi.org/10.1007/s00401-023-02562-4
https://doi.org/10.1007/s00401-023-02562-4
Publikováno v:
Chemical Communications.
Monosialoganglioside GM1-bound amyloid β-peptides have been found in patients’ brains exhibiting early pathological changes of Alzheimer’ s disease. Herein, we report the ability of non-micellar GM1 to modulate Aβ40aggregation resulting in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a312c06a111f17860c981cc349748a97
https://doi.org/10.1039/d3cc02186f
https://doi.org/10.1039/d3cc02186f
Publikováno v:
The Journal of Physical Chemistry B. 125:12446-12456
Dipeptide repeats (DPRs) are known to play important roles in C9ORF72-related amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Studies on DPRs have reported on the kinetics of aggregation, toxicity, and low-resolution morphology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47dce75988cacf6635f3fa37834cbb3
https://doi.org/10.1021/acs.jpcb.1c08149
https://doi.org/10.1021/acs.jpcb.1c08149
Autor:
Michael M. Wang, Kelly Z. Young, Naw May Pearl Cartee, Soo Jung Lee, Simon G. Keep, Magdalena I. Ivanova
Publikováno v:
Transl Stroke Res
BACKGROUND. Small vessel disease is a prevalent age-related condition linked to increased risk of dementia and stroke. We investigate the most commonly inherited form, CADASIL, caused by cysteine-involving mutations in NOTCH3. Recent studies highligh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cee534fbef928151aee24cb47b50ca
https://doi.org/10.1007/s12975-021-00908-2
https://doi.org/10.1007/s12975-021-00908-2
Autor:
Udit J. Sheth, Alexandra B. Sutter, Michael G. Kearse, Sami J. Barmada, Peter K. Todd, Shannon E. Wright, Katelyn M. Green, Brittany N. Flores, Magdalena I. Ivanova
Publikováno v:
Journal of Biological Chemistry. 294:18624-18638
Repeat-associated non-AUG (RAN) translation is a noncanonical translation initiation event that occurs at nucleotide-repeat expansion mutations that are associated with several neurodegenerative diseases, including fragile X-associated tremor ataxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80a34c206bdb129a0afa44ea65aa2fa
https://doi.org/10.1074/jbc.ra119.009951
https://doi.org/10.1074/jbc.ra119.009951