Elucidation of toxicity pathways in lung epithelial cells induced by silicon dioxide nanoparticles.

Autor: Odu Okoturo-Evans, Agnieszka Dybowska, Eugenia Valsami-Jones, John Cupitt, Magdalena Gierula, Alan R Boobis, Robert J Edwards

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e72363 (2013)

A study into the effects of amorphous nano-SiO2 particles on A549 lung epithelial cells was undertaken using proteomics to understand the interactions that occur and the biological consequences of exposure of lung to nanoparticles. Suitable condition

Externí odkaz: https://doaj.org/article/670284f8cdd24cf4bdbeb43f9e21b36d

Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling.

Autor: Sven van Eijl, Zheying Zhu, John Cupitt, Magdalena Gierula, Christine Götz, Ellen Fritsche, Robert J Edwards

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41721 (2012)

BACKGROUND: Human skin has the capacity to metabolise foreign chemicals (xenobiotics), but knowledge of the various enzymes involved is incomplete. A broad-based unbiased proteomics approach was used to describe the profile of xenobiotic metabolising

Externí odkaz: https://doaj.org/article/073c81ec69c643f796f1c7e7276a975c

Anticoagulant protein S-New insights on interactions and functions

Autor: Magdalena Gierula, Josefin Ahnström

Publikováno v: Journal of thrombosis and haemostasis : JTHREFERENCES. 18(11)

Protein S is a critical regulator of coagulation that functions as a cofactor for the activated protein C (APC) and tissue factor pathway inhibitor (TFPI) pathways. It also has direct anticoagulant functions, inhibiting the intrinsic tenase and proth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32a58fc673d064ce2445ef6f38868b5
https://pubmed.ncbi.nlm.nih.gov/32702208

Partial rescue of naturally occurring active site factor X variants through decreased inhibition by tissue factor pathway inhibitor and antithrombin

Autor: Magdalena Gierula, Josefin Ahnström, David A. Lane, Michael Laffan, Joseph Temenu

Background Activated coagulation factor X (FXa) is the serine protease component of prothrombinase, the physiological activator of prothrombin. Factor X Nottingham (A404T) and Taunton (R405G) are two naturally occurring mutations, identified in famil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886aa991836bf75287687aa89c55f1a3
http://hdl.handle.net/10044/1/73318

Identification of commonly expressed exoproteins and proteolytic cleavage events by proteomic mining of clinically-relevant UK isolates of Staphylococcus aureus

Autor: Nicola N. Lynskey, Matthew K. Siggins, Shiranee Sriskandan, Angela Kearns, Magdalena Gierula, Debra Smith, Robert Edwards, Mia Mosavie, Claire E. Turner, Bruno Pichon

Publikováno v: Smith, D S, Siggins, M K, Gierula, M, Pichon, B, Turner, C E, Lynskey, N N, Mosavie, M, Kearns, A M, Edwards, R J & Sriskandan, S 2016, ' Identification of commonly expressed exoproteins and proteolytic cleavage events by proteomic mining of clinically relevant UK isolates of Staphylococcus aureus ', Microbial Genomics, vol. 2, no. 2, pp. e000049 . https://doi.org/10.1099/mgen.0.000049

The range of exoproteins and core exoproteome of 14 S. aureus isolates representing major lineages associated with asymptomatic carriage and clinical disease in the United Kingdom was identified by mass spectrometry proteomics using a combined databa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f166f065eb6383248c363ab66c8402
http://hdl.handle.net/10044/1/29604