Molecular treatment trajectories within psoriatic T lymphocytes: a mini review

Autor: Martyna Kuczyńska, Magdalena Gabig-Cimińska, Marta Moskot

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Multiple biological processes in mammalian cells are implicated in psoriasis (Ps) development and progression, as well as in the pathogenic mechanisms associated with this chronic immune-mediated inflammatory disease (IMID). These refer to molecular

Externí odkaz: https://doaj.org/article/eab75cf60e914a699f3739197f761624

Use of Cytokine Mix-, Imiquimod-, and Serum-Induced Monoculture and Lipopolysaccharide- and Interferon Gamma-Treated Co-Culture to Establish In Vitro Psoriasis-like Inflammation Models

Autor: Katarzyna Bocheńska, Marta Moskot, Magdalena Gabig-Cimińska

Publikováno v: Cells, Vol 10, Iss 11, p 2985 (2021)

Psoriasis (Ps), commonly perceived as a skin and joint disorder, has a complex basis and results from disturbances in the sophisticated network between skin and the immune system. This makes it difficult to properly depict the complete pathomechanism

Externí odkaz: https://doaj.org/article/f3e77c1011044c06b84d77aa25a2fccd

Molecular action of isoflavone genistein in the human epithelial cell line HaCaT.

Autor: Elwira Smolińska, Marta Moskot, Joanna Jakóbkiewicz-Banecka, Grzegorz Węgrzyn, Bogdan Banecki, Aneta Szczerkowska-Dobosz, Dorota Purzycka-Bohdan, Magdalena Gabig-Cimińska

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0192297 (2018)

Due to its strong proliferation-reducing effects on keratinocytes, and also anti-inflammatory properties, the isoflavone genistein has already been proposed as a possible antipsoriatic compound. As there is still no detailed information on this topic

Externí odkaz: https://doaj.org/article/bfe7bd9d4c464cfd87a5b9a9c47fe888

A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents

Autor: Magdalena Gabig-Cimińska, Maria Skrzypkowska, Monika Ryba-Stanisławowska, Małgorzata Myśliwiec, Bartosz Słomiński

Publikováno v: Journal of Molecular Medicine (Berlin, Germany)

Abstract As the KL-VS haplotype alters secretion and activity of KLOTHO and uric acid (UA) is associated with endothelial dysfunction and inflammation, their mutual links may contribute to microalbuminuria (MA) in patients with type 1 diabetes (T1D).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef4f4ed77681f8fad3ec86b2506afaa
https://doi.org/10.1007/s00109-020-01918-7

Cellular and Gene Expression Response to the Combination of Genistein and Kaempferol in the Treatment of Mucopolysaccharidosis Type I

Autor: Magdalena Węsierska, Anna Kloska, Diego L. Medina, Joanna Jakóbkiewicz-Banecka, Magdalena Gabig-Cimińska, Marta Radzińska, Marta Moskot, Marcelina Malinowska

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1058
International Journal of Molecular Sciences, Vol 23, Iss 1058, p 1058 (2022)

Flavonoids are investigated as therapeutics for mucopolysaccharidosis, a metabolic disorder with impaired glycosaminoglycan degradation. Here we determined the effects of genistein and kaempferol, used alone or in combination, on cellular response an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2c5e30aa4c2840dbc2bba342b59dd6