Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Magdalena Bieniasz"'
Autor:
Joshua M. Corbin, Constantin Georgescu, Lin Wang, Jonathan D. Wren, Magdalena Bieniasz, Chao Xu, Adam S. Asch, Maria J. Ruiz Echevarría
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 257-272 (2023)
Blocking androgen receptor signaling is the mainstay of therapy for advanced prostate cancer (PCa). However, acquired resistance to single agents targeting this pathway results in the development of lethal castration-resistant PCa. Combination therap
Externí odkaz:
https://doaj.org/article/41fabf28d4364d8697b56a2f8a9cd7e7
Autor:
Anindya Dey, Shailendra Kumar Dhar Dwivedi, Lin Wang, Md Nazir Hossen, Fiifi Neizer-Ashun, Magdalena Bieniasz, Priyabrata Mukherjee, John D. Baird, Marla Weetall, Resham Bhattacharya
Publikováno v:
Genes and Diseases, Vol 9, Iss 6, Pp 1415-1418 (2022)
Externí odkaz:
https://doaj.org/article/a48c82a17d734bd19377dd0f2526ad7d
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101785- (2022)
Summary: Molecular cloning of BRD4-L is a challenging technique, because the DNA insert is formed by a long, GC-rich sequence, which folds into secondary structures. The present protocol defines a specific strategy to amplify BRD4-L, followed by the
Externí odkaz:
https://doaj.org/article/8599d499c2dd4291ad6fee99695de249
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-15 (2021)
Abstract High-grade serous ovarian carcinoma (HGSOC) is the most aggressive type of ovarian cancer, often diagnosed at advanced stages. Molecularly, HGSOC shows high degree of genomic instability associated with large number of genetic alterations. B
Externí odkaz:
https://doaj.org/article/6c7535b1b6594f3bb5a8810ca124ef10
Autor:
Md. Nazir Hossen, Lin Wang, Shailendra Kumar Dhar Dwivedi, Yushan Zhang, Geeta Rao, Chandra Kumar Elechalwar, Vinit Sheth, Anindya Dey, Sima Asfa, Suresh Kumar Gulla, Chao Xu, Kar‐Ming Fung, J. David Robertson, Magdalena Bieniasz, Stefan Wilhelm, Resham Bhattacharya, Priyabrata Mukherjee
Publikováno v:
Advanced Science, Vol 9, Iss 31, Pp n/a-n/a (2022)
Abstract By exploiting the self‐therapeutic properties of gold nanoparticles (GNPs) a molecular axis that promotes the growth of high‐grade serous ovarian cancer (HGSOC), one of the deadliest gynecologic malignancies with poorly understood underl
Externí odkaz:
https://doaj.org/article/afa0d0c72dab4dba82ca7006fafd0dee
Summary of in vivo studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183912a4bbb9ffbe64d5708a7e81ecc7
https://doi.org/10.1158/1078-0432.22460690.v1
https://doi.org/10.1158/1078-0432.22460690.v1
Summary of RNA sequencing (RNA seq) data of the Met superfamily kinases in 4 breast PDX models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bfbbb7cb139360eb4502ad6b41d2e9
https://doi.org/10.1158/1078-0432.22460693
https://doi.org/10.1158/1078-0432.22460693
A. MCF7 tumor growth rate in NOD/SCID mice implanted with beeswax E2 pellets, commercial 0.72 mg/60 days E2 pellets (Innovative Research of America) and control mice. Both, 0.72 mg/60 days E2 and beeswax E2 pellets equally supported estrogen dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06ae1e9a2de22aa8178d85dcdf2a39d
https://doi.org/10.1158/1078-0432.22460702.v1
https://doi.org/10.1158/1078-0432.22460702.v1
Purpose: Recent studies have demonstrated that short-form Ron (sfRon) kinase drives breast tumor progression and metastasis through robust activation of the PI3K pathway. We reasoned that upfront, concurrent inhibition of sfRon and PI3K might enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5f915a77615418620bbfe26107abd3
https://doi.org/10.1158/1078-0432.c.6524570.v1
https://doi.org/10.1158/1078-0432.c.6524570.v1
Representative co-IP Western blot showing interaction between sfRon and the p85a subunit of PI3K in MCF7-sfRon cells treated with DMSO or increasing amounts of ASALAN002, and in tumors harvested from NOD/SCID mice bearing HCI-011 (PIK3CAWT) PDX. Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa742d5aec07c365369dd8af2ba2bba
https://doi.org/10.1158/1078-0432.22460696
https://doi.org/10.1158/1078-0432.22460696