Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position

Autor: Christopher J. Moody, William Lewis, Magdalena B. Foreiter, Marc G. Hummersone, Richard T. Wheelhouse, Helen S. Summers, David Cousin, Tracey D. Bradshaw, Malcolm F. G. Stevens, Jihong Zhang

Publikováno v: MedChemComm. 9:545-553

A series of 3-(benzyl-substituted)-imidazo[5,1-d]-1,2,3,5-tetrazines (13) and related derivatives with 3-heteromethyl groups has been synthesised and screened for growth-inhibitory activity in vitro against two pairs of glioma cell lines with temozol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37dccf8e94ea21e104fc7ba2b4b0af63
https://doi.org/10.1039/c7md00554g

Chiral thiouronium salts: synthesis, characterisation and application in NMR enantio-discrimination of chiral oxoanions

Autor: Paul J. Stevenson, H. Q. Nimal Gunaratne, Peter Nockemann, Kenneth R. Seddon, Magdalena B. Foreiter, David Francis Wassell

Publikováno v: Foreiter, M B, Gunaratne, H Q N, Nockemann, P, Seddon, K R, Stevenson, P J & Wassell, D F 2013, ' Chiral thiouronium salts: synthesis, characterisation and application in NMR enantio-discrimination of chiral oxoanions ', New journal of chemistry, vol. 37, no. 2, pp. 515-533 . https://doi.org/10.1039/c2nj40632b

Chiral thioureas and functionalised chiral thiouronium salts were synthesised starting from the relatively cheap and easily available chiral amines: (S)-methylbenzylamine and rosin-derived (+)-dehydroabietylamine. The introduction of a delocalised po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fbb5338b2f87b2508aba02089bee53
https://doi.org/10.1039/c2nj40632b