Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Magdalena A. Petryniak"'
Publikováno v:
Journal of Neuroscience Research
Neuroinflammation, activation of innate immune components of the nervous system followed by an adaptive immune response, is observed in most leukodystrophies and coincides with white matter pathology, disease progression, and morbidity. Despite this,
Autor:
Marc Ekker, Gregory B. Potter, John L.R. Rubenstein, Eugenia Shevchenko, Magdalena A. Petryniak, Gabriel L. McKinsey
Publikováno v:
Molecular and Cellular Neuroscience. 40:167-186
DLX1 and DLX2 transcription factors are necessary for forebrain GABAergic neuron differentiation, migration, and survival. We generated transgenic mice that express Cre-recombinase under the control of two ultra-conserved DNA elements near the Dlx1 a
Autor:
Marc Ekker, Minoree Kohwi, Jason E. Long, Yuchio Yanagawa, Arturo Alvarez-Buylla, John L.R. Rubenstein, Kunihiko Obata, Magdalena A. Petryniak
Publikováno v:
Journal of Neuroscience. 27:6878-6891
The subventricular zone (SVZ) of the postnatal brain continuously generates olfactory bulb (OB) interneurons. We show that calretinin+, calbindin+, and dopaminergic (TH+) periglomerular OB interneurons correspond to distinct subtypes of GABAergic cel
Autor:
Joshua L. Bonkowsky, S. Ali Fatemi, Geneviève Bernard, Maria L. Escolar, Marjo S. van der Knaap, Marc C. Patterson, Magdalena A. Petryniak, Albee Messing, Stephen A. Damiani, Dean Suhr, Guy Helman, Adeline Vanderver, Raphael Schiffmann, Nancy Braverman, David H. Rowitch, Asako Takanohashi, Jeff Leonard, Amy Pizzino, Lawrence Wrabetz, Steven A. Goldman, Keith Van Haren, Florian Eichler, Stephen A. Back
Publikováno v:
Molecular Genetics and Metabolism, 114(4), 527-536. Academic Press Inc.
Helman, G, van Haren, K, Bonkowsky, J L, Bernard, G, Pizzino, A, Braverman, N, Suhr, D, Patterson, M C, Fatemi, S A, Leonard, J, van der Knaap, M S, Back, S A, Damiani, S, Goldman, S A, Takanohashi, A, Petryniak, M, Rowitch, D, Messing, A, Wrabetz, L, Schiffmann, R, Eichler, F, Escolar, M L & Vanderver, A 2015, ' Disease specific therapies in leukodystrophies and leukoencephalopathies ', Molecular Genetics and Metabolism, vol. 114, no. 4, pp. 527-536 . https://doi.org/10.1016/j.ymgme.2015.01.014
Helman, G, van Haren, K, Bonkowsky, J L, Bernard, G, Pizzino, A, Braverman, N, Suhr, D, Patterson, M C, Fatemi, S A, Leonard, J, van der Knaap, M S, Back, S A, Damiani, S, Goldman, S A, Takanohashi, A, Petryniak, M, Rowitch, D, Messing, A, Wrabetz, L, Schiffmann, R, Eichler, F, Escolar, M L & Vanderver, A 2015, ' Disease specific therapies in leukodystrophies and leukoencephalopathies ', Molecular Genetics and Metabolism, vol. 114, no. 4, pp. 527-536 . https://doi.org/10.1016/j.ymgme.2015.01.014
The leukodystrophies are a heterogeneous, often progressive group of disorders manifesting a wide range of symptoms and complications. Most of these disorders have historically had no etiologic or disease specific therapeutic approaches. Recently, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f733b3bedc27e3d8b986e18a979044
https://research.vumc.nl/en/publications/24cd9494-76eb-43f4-8b72-95bd62ca3a8f
https://research.vumc.nl/en/publications/24cd9494-76eb-43f4-8b72-95bd62ca3a8f
Missense mutation in mouse GALC mimics human gene defect and offers new insights into Krabbe disease
Autor:
Marta B. Santos, Daniel L. Marks, David H. Rowitch, Muriel T. Davisson, Gregory B. Potter, Ernesto R. Bongarzone, Magdalena A. Petryniak
Publikováno v:
Human molecular genetics. 22(17)
Krabbe disease is a devastating pediatric leukodystrophy caused by mutations in the galactocerebrosidase (GALC) gene. A significant subset of the infantile form of the disease is due to missense mutations that result in aberrant protein production. T
Publikováno v:
Biochemical Journal. 320:957-963
Secretory cleavage of the amyloid precursor protein (APP), a process that releases soluble APP derivatives (APPs) into the extracellular space, is stimulated by the activation of muscarinic receptors coupled to phosphoinositide hydrolysis. The signal
Publikováno v:
Journal of Biological Chemistry. 270:8337-8344
Stimulation of m1 and m3 muscarinic acetylcholine receptors, which are coupled to phosphoinositide hydrolysis and protein kinase C activation, has been shown to increase the release of soluble amyloid precursor protein derivatives (APPs). The effect
Autor:
I. Sophie Runquist, Hui Fu, Zijing Liu, James F. Powers, Magdalena A. Petryniak, Dimphna H. Meijer, John A. Alberta, Michael F. Kane, Yu Sun, David H. Rowitch, Shwetal Mehta, Charles D. Stiles, Gregory B. Potter, An-Chi Tien
Publikováno v:
Neuron. 69(5)
SUMMARY The bHLH transcription factors that regulate early development of the central nervous system can generally be classified as either antineural or proneural. Initial expression of antineural factors prevents cell cycle exit and thereby expands
Publikováno v:
Archivum immunologiae et therapiae experimentalis. 59(3)
Oligodendrocytes are the primary source of myelin in the adult central nervous system (CNS), and their dysfunction or loss underlies several diseases of both children and adults. Dysmyelinating and demyelinating diseases are thus attractive targets f