Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Magdalena Staniszewska"'
Autor:
Aleksandra Antos, Agnieszka Topolska-Woś, Marcin Woś, Agata Mitura, Paulina Sarzyńska, Tomasz Lipiński, Andrzej Kurylcio, Piotr Ziółkowski, Marta Świtalska, Joanna Tkaczuk-Włach, Andrzej Gamian, Wojciech P. Polkowski, Magdalena Staniszewska
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The expression of the HER2 (human epidermal growth factor receptor 2) protein in cancer cells is a well-established cancer marker used for diagnostic and therapeutic purposes in modern treatment protocols, especially in breast cancer. The go
Externí odkaz:
https://doaj.org/article/cf6a0541c3d64f9eb08c88b1383422c3
Autor:
Kinga Gostomska-Pampuch, Andrzej Gamian, Karol Rawicz-Pruszyński, Katarzyna Gęca, Joanna Tkaczuk-Włach, Ilona Jonik, Kinga Ożga, Magdalena Staniszewska
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Melibiose-derived AGE (MAGE) is an advanced glycation end-product formed in vitro in anhydrous conditions on proteins and protein-free amino acids during glycation with melibiose. Our previous studies revealed the presence of MAGE antigen in
Externí odkaz:
https://doaj.org/article/f7bbf853f51d42d7b6b709429ad26a8d
Autor:
Stephan Settelmeier, Zohreh Varasteh, Magdalena Staniszewska, Anna-Lena Beerlage, Fadi Zarrad, Wolfgang P. Fendler, Christoph Rischpler, Johannes Notni, Matthias Totzeck, Ken Herrmann, Tienush Rassaf, Ulrike B. Hendgen-Cotta
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 824 (2023)
The cardiac bioavailability of peptide drugs that inhibit harmful intracellular protein–protein interactions in cardiovascular diseases remains a challenging task in drug development. This study investigates whether a non-specific cell-targeted pep
Externí odkaz:
https://doaj.org/article/71f26396bed24156975fbdf8790bd8ba
Autor:
Magdalena Staniszewska, Agnieszka Bronowicka-Szydełko, Kinga Gostomska-Pampuch, Jerzy Szkudlarek, Arkadiusz Bartyś, Tadeusz Bieg, Elżbieta Gamian, Agata Kochman, Bolesław Picur, Jadwiga Pietkiewicz, Piotr Kuropka, Wiesław Szeja, Jerzy Wiśniewski, Piotr Ziółkowski, Andrzej Gamian
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Non-enzymatic modification of proteins by carbohydrates, known as glycation, leads to generation of advanced glycation end-products (AGEs). In our study we used in vitro generated AGEs to model glycation in vivo. We discovered in vivo analog
Externí odkaz:
https://doaj.org/article/5e928347233642c5a6d161c60deb78d8
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 581-592 (2021)
The kynurenine pathway is the major tryptophan degradation routes generating bioactive compounds important in physiology and diseases. Depending on cell type it is initiated enzymatically by tryptophan-2,3-dioxygenase (TDO) or indoleamine-2,3-dioxyge
Externí odkaz:
https://doaj.org/article/5beb9a035fb94edda59e9a8ed3659634
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 107 (2023)
Catabolism of tryptophan (Trp) is modulated by physical activity and provides a pool of active compounds: Trp is considered a calmative agent, kynurenine (Kyn) and 3-hydroxykynurenine (3-HKyn) show neurotoxic effects, kynurenic acid (Kyna) and xanthu
Externí odkaz:
https://doaj.org/article/1b72ae1d0bee421fba2aac04844a05f6
Autor:
Arne Sahm, Matthias Platzer, Philipp Koch, Yoshiyuki Henning, Martin Bens, Marco Groth, Hynek Burda, Sabine Begall, Saskia Ting, Moritz Goetz, Paul Van Daele, Magdalena Staniszewska, Jasmin Mona Klose, Pedro Fragoso Costa, Steve Hoffmann, Karol Szafranski, Philip Dammann
Publikováno v:
eLife, Vol 10 (2021)
Sexual activity and/or reproduction are associated with a doubling of life expectancy in the long-lived rodent genus Fukomys. To investigate the molecular mechanisms underlying this phenomenon, we analyzed 636 RNA-seq samples across 15 tissues. This
Externí odkaz:
https://doaj.org/article/7604cc028b8242158c4940e90b47e895
Publikováno v:
Metabolites, Vol 12, Iss 6, p 492 (2022)
We examined the relationships of tryptophan (Trp) and the metabolites of the kynurenine pathway (KP) to the occurrence of type 2 diabetes (T2D) and metabolic risk factors in obese middle-aged women. The study included 128 obese women divided into two
Externí odkaz:
https://doaj.org/article/43e39436a8504ffca91c23f7caa1684c
Autor:
Magdalena Staniszewska
Publikováno v:
Z Badań nad Książką i Księgozbiorami Historycznymi (2020)
Externí odkaz:
https://doaj.org/article/6e771e94427c4ca4bc76a19a01e9267b
Autor:
Ilona Sadok, Magdalena Staniszewska
Publikováno v:
Sensors, Vol 21, Iss 21, p 7152 (2021)
In recent years, tryptophan metabolism via the kynurenine pathway has become one of the most active research areas thanks to its involvement in a variety of physiological processes, especially in conditions associated with immune dysfunction, central
Externí odkaz:
https://doaj.org/article/179ce9f816d841ba9d192dcee2f9e37f