Výsledky vyhledávání - "Magdalena, Godzwon"

Akademický článek

Mammalian cell display with automated oligo design and library assembly allows for rapid residue level conformational epitope mapping

Autor: Niklas Berndt Thalén, Maximilian Karlander, Magnus Lundqvist, Helena Persson, Camilla Hofström, S. Pauliina Turunen, Magdalena Godzwon, Anna-Luisa Volk, Magdalena Malm, Mats Ohlin, Johan Rockberg

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)

Abstract Precise epitope determination of therapeutic antibodies is of great value as it allows for further comprehension of mechanism of action, therapeutic responsiveness prediction, avoidance of unwanted cross reactivity, and vaccine design. The g

Externí odkaz: https://doaj.org/article/e8c8e0ec47704c01a51d5a3138a80a18

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Akademický článek

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)

Abstract Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M prote

Externí odkaz: https://doaj.org/article/be6b5c313b7e4a23b226edf27ac9fea5

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Akademický článek

Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2

Publikováno v: Frontiers in Immunology, Vol 12 (2022)

Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immune mechanism

Externí odkaz: https://doaj.org/article/f92905abfadc4d269db7f2ae1d052963

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Subclass-switched anti-spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization

Autor: Arman Izadi, Arsema Hailu, Magdalena Godzwon, Sebastian Wrighton, Berit Olofsson, Tobias Schmidt, Anna Söderlund-Strand, Elizabeth Elder, Sofia Appelberg, Maria Valsjö, Olivia Larsson, Vidar Wendel-Hansen, Mats Ohlin, Wael Bahnan, Pontus Nordenfelt

Publikováno v: Proceedings of the National Academy of Sciences. 120

Antibodies play a central role in the immune defense against SARS-CoV-2. Emerging evidence has shown that nonneutralizing antibodies are important for immune defense through Fc-mediated effector functions. Antibody subclass is known to affect downstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06e5b164ce1d91dfecb2117447cf9b5e
https://doi.org/10.1073/pnas.2217590120

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A microarray-based reaction rate analysis platform. Is there evidence of validity?

Autor: Anna Säll, Mattias Levin, Magdalena Godzwon, Mats Ohlin

Publikováno v: Journal of immunological methods. 426

Monoclonal antibodies (mAbs) are major reagents for research and clinical diagnosis. For their inherently high specificities to intended antigen targets and thus low toxicity in general, they are pursued as one of the major classes of new drugs. Yet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39e7229a7642795a15989edb0b69de5
https://pubmed.ncbi.nlm.nih.gov/25536073

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