Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Magdaléna Harakaľová"'
Autor:
Julia E. Niskanen, Åsa Ohlsson, Ingrid Ljungvall, Michaela Drögemüller, Robert F. Ernst, Dennis Dooijes, Hanneke W. M. van Deutekom, J. Peter van Tintelen, Christian J. B. Snijders Blok, Marion van Vugt, Jessica van Setten, Folkert W. Asselbergs, Aleksandra Domanjko Petrič, Milla Salonen, Sruthi Hundi, Matthias Hörtenhuber, DoGA consortium, Juha Kere, W. Glen Pyle, Jonas Donner, Alex V. Postma, Tosso Leeb, Göran Andersson, Marjo K. Hytönen, Jens Häggström, Maria Wiberg, Jana Friederich, Jenny Eberhard, Magdalena Harakalova, Frank G. van Steenbeek, Gerhard Wess, Hannes Lohi
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-21 (2023)
Abstract Background Dilated cardiomyopathy (DCM) is a life-threatening heart disease and a common cause of heart failure due to systolic dysfunction and subsequent left or biventricular dilatation. A significant number of cases have a genetic etiolog
Externí odkaz:
https://doaj.org/article/49a1dbcf15a6421cbf422ecc2a464ea9
Autor:
Talitha C. F. Spanjersberg, Loes A. Oosterhoff, Hedwig S. Kruitwagen, Noortje A. M. van den Dungen, Johannes C. M. Vernooij, Folkert W. Asselbergs, Michal Mokry, Bart Spee, Magdalena Harakalova, Frank G. van Steenbeek
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Vascular pathologies show locational predisposition throughout the body; further insights into the transcriptomics basis of this vascular heterogeneity are needed. We analyzed transcriptomes from cultured endothelial cells and vascular smoot
Externí odkaz:
https://doaj.org/article/084d9af137ee4c1b8e300e79be3a0038
Autor:
Marie de Bakker, Teun B. Petersen, K. Martijn Akkerhuis, Magdalena Harakalova, Victor A. Umans, Tjeerd Germans, Kadir Caliskan, Peter D. Katsikis, Peter J. van der Spek, Navin Suthahar, Rudolf A. de Boer, Dimitris Rizopoulos, Folkert W. Asselbergs, Eric Boersma, Isabella Kardys
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background Studies focusing on sex differences in circulating proteins in patients with heart failure with reduced ejection fraction (HFrEF) are scarce. Insight into sex-specific cardiovascular protein profiles and their associations with th
Externí odkaz:
https://doaj.org/article/7452d03e3e184ddc9f2d6d439dc0745f
Autor:
Valentina Balducci, Francesco Scardigli, Magdalena Harakalova, J. Peter. van Tintelen, Pieter A. Doevendans, Kevin D. Costa, Irene C. Turnbull, Joost P. G. Sluijter, Francesca Stillitano
Publikováno v:
Stem Cell Research, Vol 72, Iss , Pp 103208- (2023)
The rare genetic alteration PLN-c.(40_42delAGA), leading to the deletion of arginine 14 (p.R14del) in phospholamban, is associated with dilated and arrhythmogenic cardiomyopathies occurring in early-adulthood. However, some carriers remain asymptomat
Externí odkaz:
https://doaj.org/article/388758bbc8f347e6ba63047bd7670b59
Autor:
Teun B. Petersen, Marie de Bakker, Folkert W. Asselbergs, Magdalena Harakalova, K. Martijn Akkerhuis, Jasper J. Brugts, Jan van Ramshorst, R. Thomas Lumbers, Rachel M. Ostroff, Peter D. Katsikis, Peter J. van der Spek, Victor A. Umans, Eric Boersma, Dimitris Rizopoulos, Isabella Kardys
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104655- (2023)
Summary: Background: HFrEF is a heterogenous condition with high mortality. We used serial assessments of 4210 circulating proteins to identify distinct novel protein-based HFrEF subphenotypes and to investigate underlying dynamic biological mechanis
Externí odkaz:
https://doaj.org/article/f7d15c4f779b430a93c911178ae4dfdd
Autor:
Karen R. Gaar-Humphreys, Alyssa van den Brink, Mark Wekking, Folkert W. Asselbergs, Frank G. van Steenbeek, Magdalena Harakalova, Jiayi Pei
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Inherited cardiomyopathies caused by pathological genetic variants include multiple subtypes of heart disease. Advances in next-generation sequencing (NGS) techniques have allowed for the identification of numerous genetic variants as pathological va
Externí odkaz:
https://doaj.org/article/46f07cef590b4d50b2ef9234bac68380
Autor:
Nishka Mittal, Jaydev Dave, Magdalena Harakalova, J. Peter. van Tintelen, Folkert W. Asselbergs, Pieter A. Doevendans, Kevin D. Costa, Irene C. Turnbull, Francesca Stillitano
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102737- (2022)
The R14del pathogenic variant in the phospholamban (PLN) gene (PLN-R14del), has been identified in families with hereditary cardiomyopathy, including dilated and arrhythmogenic cardiomyopathies. Here we have generated human iPSC lines from five PLN-R
Externí odkaz:
https://doaj.org/article/42ffbf12f2cb4306961af5cb94213fa4
Autor:
Louise C. Gregory, Carolina B. Ferreira, Sara K. Young-Baird, Hywel J. Williams, Magdalena Harakalova, Gijs van Haaften, Sofia A. Rahman, Carles Gaston-Massuet, Daniel Kelberman, GOSgene, Waseem Qasim, Sally A. Camper, Thomas E. Dever, Pratik Shah, Iain C.A.F. Robinson, Mehul T. Dattani
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 470-480 (2019)
Background: The heterotrimeric GTP-binding protein eIF2 forms a ternary complex with initiator methionyl-tRNA and recruits it to the 40S ribosomal subunit for start codon selection and thereby initiates protein synthesis. Mutations in EIF2S3, encodin
Externí odkaz:
https://doaj.org/article/61da4410358e47e8afd4a94b157fdcae
Autor:
Renee G.C. Maas, Soah Lee, Magdalena Harakalova, Christian J.B. Snijders Blok, William R. Goodyer, Jesper Hjortnaes, Pieter A.F.M. Doevendans, Linda W. Van Laake, Jolanda van der Velden, Folkert W. Asselbergs, Joseph C. Wu, Joost P.G. Sluijter, Sean M. Wu, Jan W. Buikema
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100334- (2021)
Summary: Since the discovery of human induced pluripotent stem cells (hiPSCs), numerous strategies have been established to efficiently derive cardiomyocytes from hiPSCs (hiPSC-CMs). Here, we describe a cost-effective strategy for the subsequent mass
Externí odkaz:
https://doaj.org/article/c67e008223eb41c98fd3c291c61dc6fd
Autor:
Karen R. Gaar-Humphreys, Talitha C. F. Spanjersberg, Giorgia Santarelli, Guy C. M. Grinwis, Viktor Szatmári, Bernard A. J. Roelen, Aryan Vink, J. Peter van Tintelen, Folkert W. Asselbergs, Hille Fieten, Magdalena Harakalova, Frank G. van Steenbeek
Publikováno v:
Animals, Vol 12, Iss 13, p 1679 (2022)
Cardiac disease is a leading cause of death for both humans and dogs. Genetic cardiomyopathies, including dilated cardiomyopathy (DCM), account for a proportion of these cases in both species. Patients may suffer from ventricular enlargement and syst
Externí odkaz:
https://doaj.org/article/9e90264b25cf431d9ccb7bdab20de139