Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Magda N. A. Nasr"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract A new series of 7-substituted coumarin scaffolds containing a methyl ester moiety at the C4-position were synthesized and tested for their in vitro anti-proliferative activity against MCF-7 and MDA-MB-231 breast cancer cell lines using Doxor
Externí odkaz:
https://doaj.org/article/b3c4d846f23c43b3ba52fa4cd9357b3b
Publikováno v:
Journal of Chemistry, Vol 2022 (2022)
In the present study, a set of 2-anilino-4-alkylaminoquinazoline derivatives were synthesized and tested for their antitumor activities in vitro against a panel of four human cancer cell lines and for their DNA-binding affinity. Among the synthesized
Externí odkaz:
https://doaj.org/article/757dc1a8afb54c519a636c6738741d44
Publikováno v:
Archiv der Pharmazie. 355:2200029
Based on modulation of the monastrol scaffold, two series of pyrimidinone derivatives, 3a-e and 5a-k, were designed, synthesized, and investigated for their in vitro anticancer activity. Compound 5j exhibited the most potent cytotoxic activity agains
Publikováno v:
Bioorganic chemistry. 103
Three new series of phenyl dihydropyridazinone derivatives 4b-8i have been designed, synthesized and evaluated for their anticancer activity against different cancer cell lines. Nine compounds showed strong inhibitory activity, among which compound 8
Publikováno v:
International Journal of Organic Chemistry. :369-388
Several modifications in CA-4 were reported in literature for the development of various tubulin inhibitors. In our study, twenty-two newly synthesized heterocyclic derivatives of Combretastatin A-4 (CA-4) have been tested for their cytotoxic effect
Publikováno v:
Heterocyclic Communications. 21:367-375
New pyrazoles have been synthesized and evaluated as breast cancer cell growth inhibitors. Condensation of the substituted pyrazole-4-carbaldehyde 1 with acetophenone and chloroacetophenone afforded α, β-unsaturated ketones 2 and 3, respectively. C
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115373
New series of triazolo[4,3-c]quinazolines were designed, synthesized and their structures were elucidated using different spectroscopic techniques. They were evaluated for their in vitro antitumor activity against HepG2, MCF-7, PC-3, HCT-116 and HeLa
Autor:
Magda A. El-Sherbeny, Naglaa I. Abdel-Aziz, Mariam A. Ghaly, Ghada M. Suddek, Shahenda M. El-Messery, Mahmoud B. El-Ashmawy, Said M. Bayomi, Magda N. A. Nasr, Hassan A. El-Kashef, Magda A.-A. El-Sayed
Publikováno v:
European Journal of Medicinal Chemistry. 101:584-594
New curcumin analogues have been synthesized and their antioxidant activities were investigated by measuring their free radical scavenging capacities. The in vitro and in vivo antitumor activities of the synthesized compounds on Ehrlich ascites carci
Publikováno v:
Medicinal Chemistry Research. 22:3943-3952
New series of pyrido[2,3-d]pyrimidines such as; 5-(4-aryl-5-sulfanyl-4H-[1,2,4]triazol-3-yl) 1H,3H,8H-pyrido[2,3-d]pyrimidine-2,4,7-triones 6, 7; S-[3-(2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)-4-(4-substituted phenyl)-4H-[1,2,4]
Autor:
Farid A. Badria, Laila A. Abou-Zeid, Mahmoud B. El-Ashmawy, Magda N. A. Nasr, Said M. Bayomi, Mariam A. Ghaly, Naglaa I. Abdel-Aziz, Hassan A. El-Kashef, Magda A. El-Sherbeny
Publikováno v:
Medicinal Chemistry Research. 22:1147-1162
Twenty-four new compounds were prepared, taking curcumin as a lead, in order to explore their antioxidant and antitumor properties. The capacities of these derivatives to scavenge the 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical ca