Large CRISPR-Cas-induced deletions in the oxamniquine resistance locus of the human parasite Schistosoma mansoni [version 2; peer review: 4 approved]

Autor: Geetha Sankaranarayanan, Avril Coghlan, Patrick Driguez, Magda E. Lotkowska, Mandy Sanders, Nancy Holroyd, Alan Tracey, Matthew Berriman, Gabriel Rinaldi

Publikováno v: Wellcome Open Research, Vol 5 (2021)

Background. At least 250 million people worldwide suffer from schistosomiasis, caused by Schistosoma worms. Genome sequences for several Schistosoma species are available, including a high-quality annotated reference for Schistosoma mansoni. There is

Externí odkaz: https://doaj.org/article/002e813d7f0844b3a6df3a8d312f8671

Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

Autor: Matthew Berriman, J. Alexandra Rowe, Simon J. Draper, Michael P. Barrett, Sarah E. Silk, Geetha Sankaranarayanan, Wiebke Nahrendorf, Philip J Spence, Diana Munoz Sandoval, Mandy Sanders, Angela M. Minassian, Clément Regnault, Alasdair Ivens, Ruth O. Payne, N Venkatraman, Adam J. Reid, Magda E. Lotkowska, Áine O'Toole, Kathryn H. Milne, Nick J. Edwards, Adrian V. S. Hill

Publikováno v: eLife, Vol 10 (2021)
Milne, K, Ivens, A, Reid, A J, Lotkowska, M E, O'Toole, Á, Sankaranarayanan, G, Munoz Sandoval, D, Nahrendorf, W, Regnault, C, Edwards, N J, Silk, S E, Payne, R O, Minassian, A M, Venkatraman, N, Sanders, M, Hill, A V S, Barrett, M P, Berriman, M, Draper, S J, Rowe, A J & Spence, P J 2021, ' Mapping immune variation and var gene switching in naïve hosts infected with Plasmodium falciparum ', eLIFE, vol. 10, e62800 . https://doi.org/10.7554/eLife.62800

Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, ask

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dabfbdeab670e7303331411e94d6707
https://elifesciences.org/articles/62800

Population genomic evidence that human and animal infections in Africa come from the same populations of Dracunculus medinensis

Autor: Guillaume Sallé, Makoy Yibi Logora, Hayley M. Bennett, Stephen R. Doyle, Geetha Sankaranarayanan, Michael J. Yabsley, Mesfin Wossen, Zahra Abdellah, Mark L. Eberhard, Magda E. Lotkowska, Jeremy M. Foster, Matthew Berriman, Cheick Oumar Coulibaly, Christopher A. Cleveland, Nancy Holroyd, Adam Weiss, Thomas Huckvale, Alan Tracey, James Cotton, Albrecht I. Schulte-Hostedde, Ouakou Tchindebet, Caroline Durrant, Elizabeth A. Thiele, Ernesto Ruiz-Tiben

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14 (11), 24 p. ⟨10.1371/journal.pntd.0008623⟩
PLoS Neglected Tropical Diseases, Vol 14, Iss 11, p e0008623 (2020)

Background Guinea worm–Dracunculus medinensis–was historically one of the major parasites of humans and has been known since antiquity. Now, Guinea worm is on the brink of eradication, as efforts to interrupt transmission have reduced the annual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3410dda61040ef230d9451d100121b57
https://hal.inrae.fr/hal-03107696

Mapping immune variation and

Autor: Kathryn, Milne, Alasdair, Ivens, Adam J, Reid, Magda E, Lotkowska, Aine, O'Toole, Geetha, Sankaranarayanan, Diana, Munoz Sandoval, Wiebke, Nahrendorf, Clement, Regnault, Nick J, Edwards, Sarah E, Silk, Ruth O, Payne, Angela M, Minassian, Navin, Venkatraman, Mandy J, Sanders, Adrian Vs, Hill, Michael, Barrett, Matthew, Berriman, Simon J, Draper, J Alexandra, Rowe, Philip J, Spence

Publikováno v: eLife

Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, ask

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1db1698df5abca2d116552ffd308bb55
https://pubmed.ncbi.nlm.nih.gov/33648633

Repeated clinical malaria episodes are associated with modification of the immune system in children

Autor: Magda E. Lotkowska, S Manni, Adam J. Reid, Mandy Sanders, E. P. de Villiers, Juliana Wambua, Philip Bejon, Chris I. Newbold, George Nyangweso, Mario Recker, Rhys M. Adams, John Joseph Valletta, Domtila Kimani, Y Bediako, Francis M. Ndungu, Kevin Marsh, Lin J-W., Addy Jwg., Jan Sodenkamp, Jean Langhorne, Joyce M. Ngoi, Jedidah Mwacharo, Matthew Berriman, O Kai

Publikováno v: BMC Medicine, Vol 17, Iss 1, Pp 1-14 (2019)
BMC Medicine

The study received funding from the UK Medical Research Council, (MRC Programme grant #: MR/M003906/1). MB and AR are supported by the Wellcome Trust (Grant #: WT 206194). Background There are over 200 million reported cases of malaria each year, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2126ae06032ab0ca75ff2784098dc60d
http://ora.ox.ac.uk/objects/uuid: