Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Magda Bictash"'
Autor:
Magda L Atilano, Sebastian Grönke, Teresa Niccoli, Liam Kempthorne, Oliver Hahn, Javier Morón-Oset, Oliver Hendrich, Miranda Dyson, Mirjam Lisette Adams, Alexander Hull, Marie-Therese Salcher-Konrad, Amy Monaghan, Magda Bictash, Idoia Glaria, Adrian M Isaacs, Linda Partridge
Publikováno v:
eLife, Vol 10 (2021)
G4C2 repeat expansions within the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The repeats undergo repeat-associated non-ATG translation to generate toxic dipeptide repeat pr
Externí odkaz:
https://doaj.org/article/55824973121a40c69b33db796ae2c8b6
Autor:
Marc P M Soutar, Daniela Melandri, Benjamin O’Callaghan, Emily Annuario, Amy E Monaghan, Natalie J Welsh, Karishma D’Sa, Sebastian Guelfi, David Zhang, Alan Pittman, Daniah Trabzuni, Anouk H A Verboven, Kylie S Pan, Demis A Kia, Magda Bictash, Sonia Gandhi, Henry Houlden, Mark R Cookson, Nael Nadif Kasri, Nicholas W Wood, Andrew B Singleton, John Hardy, Paul J Whiting, Cornelis Blauwendraat, Alexander J Whitworth, Claudia Manzoni, Mina Ryten, Patrick A Lewis, Hélène Plun-Favreau
Publikováno v:
Brain. 145:4349-4367
Parkinson's disease is a common incurable neurodegenerative disease. The identification of genetic variants via genome-wide association studies has considerably advanced our understanding of the Parkinson's disease genetic risk. Understanding the fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12f2a7e7a1bd11cd4fd4af51e6ec49d
https://doi.org/10.1093/brain/awac325
https://doi.org/10.1093/brain/awac325
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
Molecular Neurodegeneration
Molecular Neurodegeneration
The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active area of research. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cdd110eddc06e58e362b38bbfc926f
https://doaj.org/article/48f23724cf0c40cfa6299dd0dfb646c5
https://doaj.org/article/48f23724cf0c40cfa6299dd0dfb646c5
Publikováno v:
Slas Discovery
Iterative screening is a process in which screening is done in batches, with each batch filled by using machine learning to select the most promising compounds from the library based on the previous results. We believe iterative screening is poised t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a46567ea7b830c56425924f8d9cce1
https://doi.org/10.1177/2472555220949495
https://doi.org/10.1177/2472555220949495
Autor:
Nicky Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah Woodward, Benjamin Atkinson, Elliott Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnu, Sarah Jolly, Luca Vecchia, Reinis Ruza, Svend Kjaer, Steven Howell, Ambrosius Snidjers, Magda Bictash, Patricia Salinas, Jean-Paul Vincent, Yvonne Jones, Paul Whiting, Paul Fish
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human disease such as colorectal cancer and Alzheimer’s di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8addc522ec8ef944de3c1786ccffb9ca
https://doi.org/10.26434/chemrxiv-2022-f05w8
https://doi.org/10.26434/chemrxiv-2022-f05w8
Autor:
Amy Monaghan, Paul Whiting, James Hillier, Svend Kjaer, Reinis R. Ruza, Jean-Paul Vincent, S. Frew, Paul V. Fish, L. Vecchia, William Mahy, James Sipthorp, Fredrik Svensson, Nicky J. Willis, Magda Bictash, Hannah Woodward, Patricia C. Salinas, Yuguang Zhao, E. Yvonne Jones
Publikováno v:
Journal of Medicinal Chemistry. 63:12942-12956
Carboxylesterase Notum is a negative regulator of the Wnt signaling pathway. There is an emerging understanding of the role Notum plays in disease, supporting the need to discover new small-molecule inhibitors. A crystallographic X-ray fragment scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deae46cf90f6f7beda225afadafa1e17
https://doi.org/10.1021/acs.jmedchem.0c01391
https://doi.org/10.1021/acs.jmedchem.0c01391
Autor:
Nicky J. Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah L. Woodward, Benjamin N. Atkinson, Elliott D. Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnù, Sarah Jolly, Luca Vecchia, Reinis R. Ruza, Svend Kjær, Steven Howell, Ambrosius P. Snijders, Magda Bictash, Patricia C. Salinas, Jean-Paul Vincent, E. Yvonne Jones, Paul Whiting, Paul V. Fish
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human diseases such as colorectal cancer and Alzheimer's dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3474b8ac04a0b606e41a67edadf62c69
Autor:
Yuguang Zhao, William Mahy, Nicky J. Willis, Hannah L. Woodward, David Steadman, Elliott D. Bayle, Benjamin N. Atkinson, James Sipthorp, Luca Vecchia, Reinis R. Ruza, Karl Harlos, Fiona Jeganathan, Stefan Constantinou, Artur Costa, Svend Kjær, Magda Bictash, Patricia C. Salinas, Paul Whiting, Jean-Paul Vincent, Paul V. Fish, E. Yvonne Jones
The Wnt signaling suppressor Notum is a promising target for osteoporosis, Alzheimer's disease, and colorectal cancers. To develop novel Notum inhibitors, we used an X-ray crystallographic fragment screen with the Diamond-SGC Poised Library (DSPL) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f547dc38fab64d9f08bf48b45b75fa9e
Autor:
David Steadman, Benjamin N. Atkinson, Yuguang Zhao, Nicky J. Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, E. Yvonne Jones, Paul V. Fish, Fredrik Svensson
Publikováno v:
Journal of medicinal chemistry. 65(1)
Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Inhibitors of Notum could be of use in diseases where dysfunctional Notum activity is an underlying cause. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40edd35a69ac0b95580d171b01ebf3b1
https://pubmed.ncbi.nlm.nih.gov/34939789
https://pubmed.ncbi.nlm.nih.gov/34939789
Autor:
Oliver Hahn, Sebastian Grönke, Oliver Hendrich, Alexander Hull, Miranda C. Dyson, Adrian M. Isaacs, Idoia Glaria, Magda L. Atilano, Linda Partridge, Liam Kempthorne, Amy Monaghan, Javier Morón-Oset, Marie-Therese Salcher-Konrad, Teresa Niccoli, Magda Bictash, Mirjam Lisette Adams
Publikováno v:
Elife
eLife
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
G4C2 repeat expansions within the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The repeats undergo repeat-associated non-ATG translation to generate toxic dipeptide repeat pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049e2373f4ec78a5ad540b032b74cbe5
https://hdl.handle.net/21.11116/0000-000A-FAE7-8
https://hdl.handle.net/21.11116/0000-000A-FAE7-8