Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Magda, Bahcall"'
Autor:
Pasi A. Jänne, Stephen Wang, Sujuan Guo, Jiannan Guo, Paul T. Kirschmeier, Jens Köhler, Zihan Wei, Fangxin Hong, Pratik R. Chopade, Prafulla C. Gokhale, Christie J. Lau, Kshiti H. Dholakia, Nam Doo Kim, Taebo Sim, Luke J. Taus, Yanan Kuang, Cloud P. Paweletz, Magda Bahcall
Application of Bliss independence to test for synergy effect of TKI combination treatment in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4903139a78bc221e2202f3b12db12a51
https://doi.org/10.1158/1535-7163.22521927.v1
https://doi.org/10.1158/1535-7163.22521927.v1
Autor:
Geoffrey R. Oxnard, Pasi A. Jänne, Lynette M. Sholl, Michael T. Jaklitsch, Mark M. Awad, Christine A. Lydon, Nam Doo Kim, Adrian G. Sacher, Yanan Kuang, Ryan S. Alden, Jyoti D. Patel, Cloud P. Paweletz, Taebo Sim, Magda Bahcall
Supplementary Table S2 shows type I and II MET kinase inhibitors and key trials studying their activity lung cancer populations enriched for MET-dependence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15259866f9abcdf86d7e410f5beeefec
https://doi.org/10.1158/2159-8290.22531684.v1
https://doi.org/10.1158/2159-8290.22531684.v1
Autor:
Geoffrey R. Oxnard, Pasi A. Jänne, Lynette M. Sholl, Michael T. Jaklitsch, Mark M. Awad, Christine A. Lydon, Nam Doo Kim, Adrian G. Sacher, Yanan Kuang, Ryan S. Alden, Jyoti D. Patel, Cloud P. Paweletz, Taebo Sim, Magda Bahcall
Supplementary Figure S2 shows expression of D1228V mutation in PC9 cells as confirmed by RT-PCR and cDNA sequencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1895aa1d85644a36ffd00d28504bd3
https://doi.org/10.1158/2159-8290.22531693
https://doi.org/10.1158/2159-8290.22531693
Autor:
Pasi A. Jänne, Stephen Wang, Sujuan Guo, Jiannan Guo, Paul T. Kirschmeier, Jens Köhler, Zihan Wei, Fangxin Hong, Pratik R. Chopade, Prafulla C. Gokhale, Christie J. Lau, Kshiti H. Dholakia, Nam Doo Kim, Taebo Sim, Luke J. Taus, Yanan Kuang, Cloud P. Paweletz, Magda Bahcall
MET-targeted therapies are clinically effective in MET-amplified and MET exon 14 deletion mutant (METex14) non–small cell lung cancers (NSCLCs), but their efficacy is limited by the development of drug resistance. Structurally distinct MET tyrosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb636b4d303925dcf3349ce844b41a8
https://doi.org/10.1158/1535-7163.c.6543231.v1
https://doi.org/10.1158/1535-7163.c.6543231.v1
Autor:
Geoffrey R. Oxnard, Pasi A. Jänne, Lynette M. Sholl, Michael T. Jaklitsch, Mark M. Awad, Christine A. Lydon, Nam Doo Kim, Adrian G. Sacher, Yanan Kuang, Ryan S. Alden, Jyoti D. Patel, Cloud P. Paweletz, Taebo Sim, Magda Bahcall
Supplementary Table S1 shows variants identified in pre-treatment and post-treatment tumor targeted next-generation sequencing (NGS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6e99e786909d9d65f1f58ad0d301f3
https://doi.org/10.1158/2159-8290.22531687
https://doi.org/10.1158/2159-8290.22531687
Autor:
Pasi A. Jänne, Stephen Wang, Sujuan Guo, Jiannan Guo, Paul T. Kirschmeier, Jens Köhler, Zihan Wei, Fangxin Hong, Pratik R. Chopade, Prafulla C. Gokhale, Christie J. Lau, Kshiti H. Dholakia, Nam Doo Kim, Taebo Sim, Luke J. Taus, Yanan Kuang, Cloud P. Paweletz, Magda Bahcall
Supplementary Figures S1-3; Supplementary Tables S1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53186772e45cde82b5f37f176dc5fdfc
https://doi.org/10.1158/1535-7163.22521930.v1
https://doi.org/10.1158/1535-7163.22521930.v1
Autor:
Geoffrey R. Oxnard, Pasi A. Jänne, Lynette M. Sholl, Michael T. Jaklitsch, Mark M. Awad, Christine A. Lydon, Nam Doo Kim, Adrian G. Sacher, Yanan Kuang, Ryan S. Alden, Jyoti D. Patel, Cloud P. Paweletz, Taebo Sim, Magda Bahcall
Supplementary methods, including croplet digital PCR for MET D1228V; molecular docking study; Molecular Dynamics Simulations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66178e86266b7f57556717acb447e4b9
https://doi.org/10.1158/2159-8290.22531690
https://doi.org/10.1158/2159-8290.22531690
Autor:
Geoffrey R. Oxnard, Pasi A. Jänne, Lynette M. Sholl, Michael T. Jaklitsch, Mark M. Awad, Christine A. Lydon, Nam Doo Kim, Adrian G. Sacher, Yanan Kuang, Ryan S. Alden, Jyoti D. Patel, Cloud P. Paweletz, Taebo Sim, Magda Bahcall
Supplementary Figure S1 shows presence of the known EGFR exon 19 deletion and high level MET amplification, both of which had been present on prior tumor NGS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c970c4b74afc4d5333f9aa69ad783a10
https://doi.org/10.1158/2159-8290.22531696.v1
https://doi.org/10.1158/2159-8290.22531696.v1
Autor:
Geoffrey R. Oxnard, Pasi A. Jänne, Lynette M. Sholl, Michael T. Jaklitsch, Mark M. Awad, Christine A. Lydon, Nam Doo Kim, Adrian G. Sacher, Yanan Kuang, Ryan S. Alden, Jyoti D. Patel, Cloud P. Paweletz, Taebo Sim, Magda Bahcall
Supplementary Figure Legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d0595d6657535e5c5ceb1a1d16ded0
https://doi.org/10.1158/2159-8290.22531699
https://doi.org/10.1158/2159-8290.22531699
Autor:
Geoffrey R. Oxnard, Pasi A. Jänne, Lynette M. Sholl, Michael T. Jaklitsch, Mark M. Awad, Christine A. Lydon, Nam Doo Kim, Adrian G. Sacher, Yanan Kuang, Ryan S. Alden, Jyoti D. Patel, Cloud P. Paweletz, Taebo Sim, Magda Bahcall
Amplified and/or mutated MET can act as both a primary oncogenic driver and as a promoter of tyrosine kinase inhibitor (TKI) resistance in non–small cell lung cancer (NSCLC). However, the landscape of MET-specific targeting agents remains underdeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f2e5d3751318d33e0581bb264f2fbd
https://doi.org/10.1158/2159-8290.c.6546440
https://doi.org/10.1158/2159-8290.c.6546440