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Targeting Serotonin 2A and Adrenergic α1 Receptors for Ocular Antihypertensive Agents: Discovery of 3,4‐Dihydropyrazino[1,2‐b]indazol‐1(2H)‐one Derivatives.

Autor: Furlotti, Guido, Alisi, Maria Alessandra, Cazzolla, Nicola, Ceccacci, Francesca, Garrone, Beatrice, Gasperi, Tecla, La Bella, Angela, Leonelli, Francesca, Loreto, Maria Antonietta, Magarò, Gabriele, Mangano, Giorgina, Bettolo, Rinaldo Marini, Masini, Emanuela, Miceli, Martina, Migneco, Luisa Maria, Vitiello, Marco

Publikováno v: ChemMedChem; 8/10/2018, Vol. 13 Issue 15, p1597-1607, 11p

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Targeting Serotonin 2A and Adrenergic α1 Receptors for Ocular Antihypertensive Agents: Discovery of 3,4-Dihydropyrazino[1,2-b]indazol-1(2H)-one Derivatives

Autor: M. A. Loreto, Marco Vitiello, Beatrice Garrone, Martina Miceli, Maria Alessandra Alisi, Magaro' Gabriele, Rinaldo Marini Bettolo, Emanuela Masini, Luisa Maria Migneco, Guido Furlotti, Francesca Leonelli, Nicola Cazzolla, Giorgina Mangano, Tecla Gasperi, Francesca Ceccacci, Angela La Bella

Publikováno v: ChemMedChem
13 (2018): 1597–1607. doi:10.1002/cmdc.201800199
info:cnr-pdr/source/autori:Furlotti G. (a); Alisi M. A. (a); Cazzolla N. (a); Ceccacci F. (b,f); Garrone B. (a); Gasperi T. (d); La Bella A. (b); Leonelli F. (b,c); Loreto M. A. (b); Magarò G. (a); Mangano G. (a); Marini Bettolo R. (b); Masini E. (e); Miceli M. (d); Migneco L. M. (b); Vitiello M. (a)/titolo:Targeting Serotonin 2A and Adrenergic alfa1 Receptors for Ocular Antihypertensive Agents: Discovery of 3,4-Dihydropyrazino[1,2-b]indazol-1(2H)-one Derivatives/doi:10.1002%2Fcmdc.201800199/rivista:ChemMedChem (Print)/anno:2018/pagina_da:1597/pagina_a:1607/intervallo_pagine:1597–1607/volume:13

Glaucoma affects millions of people worldwide, causing optic nerve damage and blindness. The elevation of the intraocular pressure (IOP) is the main risk factor associated with this pathology, and nowadays, the key therapeutic target of the existing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612c3db8946e01f1e85f720922748c76
https://hdl.handle.net/11590/336581