Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Magang Shou"'
Autor:
C. Charles Lin, Jiunn H. Lin, James A. Yergey, Wei Tang, A. David Rodrigues, Bradley K. Wong, Ping Lu, Thomas A. Baillie, Jason S. Ngui, Qin Mei, Cuyue Tang, Rominder Singh, Thomas H. Rushmore, Paul G. Pearson, Dan Cui, Yuh Lin, Magang Shou
Publikováno v:
Current Drug Metabolism. 2:17-36
The most common drug-drug interactions may be understood in terms of alterations of metabolism, associated primarily with changes in the activity of cytochrome P450 (CYP) enzymes. Kinetic parameters such as K m , V max , K i and K a , which describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20285ed6becc136191602e0cbf544d2
https://doi.org/10.2174/1389200013338784
https://doi.org/10.2174/1389200013338784
Autor:
Anthony Y. H. Lu, Magang Shou
Publikováno v:
Drug Metabolism and Disposition. 37:925-931
Cytochrome P450 (P450) is the superfamily of enzymes responsible for biotransformation of endobiotics and xenobiotics. However, their large isoform multiplicity, inducibility, diverse structure, widespread distribution, polymorphic expression, and br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bdb5734e132a91ed3663127cadb3f9
https://doi.org/10.1124/dmd.108.025718
https://doi.org/10.1124/dmd.108.025718
Publikováno v:
Drug Metabolism and Disposition. 36:2414-2418
Imatinib, a potent and selective protein tyrosine kinase inhibitor, has been approved for the treatment of chronic myelogenous leukemia and metastatic and unresectable malignant gastrointestinal stromal tumors. In vitro metabolism of imatinib was inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e182e0d0c78aa5f301a0be4ac26024
https://doi.org/10.1124/dmd.108.023085
https://doi.org/10.1124/dmd.108.023085
Publikováno v:
Drug Metabolism and Disposition. 34:2073-2078
Drug transporters have been shown to alter drug metabolism. Similarly, bioactivation of drugs may also be altered by drug transporters. The aim of this work was to examine the role of P-glycoprotein (Pgp) in the bioactivation of a Pgp substrate, ralo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661042c2143a61bd81187bf7991b4f04
https://doi.org/10.1124/dmd.106.012179
https://doi.org/10.1124/dmd.106.012179
Autor:
Magang Shou, Ryan Norcross, Ping Lu, Brian A. Carr, Catherine Booth-Genthe, Yulin Fang, A. David Rodrigues, Tom Rushmore
Publikováno v:
Drug Metabolism and Disposition. 34:1703-1712
The rhesus monkey (Macaca mulatta) is a primate species used extensively as a preclinical safety species in drug development. In this report, we describe the cloning, expression, and characterization of CYP3A64 (AY334551), a CYP3A4 homolog expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3748da3b97d804d1d41edf8f5f91a858
https://doi.org/10.1124/dmd.106.009977
https://doi.org/10.1124/dmd.106.009977
Autor:
Donghui Cui, A. David Rodrigues, Magang Shou, Bennett Ma, Thomas H. Rushmore, Michael L. Schrag
Publikováno v:
Drug Metabolism and Disposition. 32:1299-1303
Sulfation of ethinyl estradiol (EE) is a major pathway of first pass metabolism in both the intestine and liver. Consequently, we sought to identify the human sulfotransferases (SULTs) involved in the 3-O-sulfation of EE (EE-SULT). Based on the resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cde8d237642c0e4ac57dbd30197503f8
https://doi.org/10.1124/dmd.32.11.1299
https://doi.org/10.1124/dmd.32.11.1299
Autor:
Matthew P. Braun, Thomayant Prueksaritanont, Michael A. Wallace, Byron H. Arison, Xiao Yu, Donghui Cui, James A. Yergey, Raju Subramanian, Magang Shou
Publikováno v:
Drug Metabolism and Disposition. 32:848-861
Compound A (3-[2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthyrindin-2-yl)propyl]-imidazolidin-1-yl]-3(S)-(6-methoxy-pyridin-3-yl)-propionic acid), a potent and selective antagonist of integrin alpha(v)beta(3) receptor, is under development for treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b276a48204e837a4069b655f46c159
https://doi.org/10.1124/dmd.32.8.848
https://doi.org/10.1124/dmd.32.8.848
Autor:
Magang Shou, Irina A. Pikuleva, Natalia Mast, Ulla Andersson, Ryan Norcross, Ingemar Björkhem, Kazuo Nakayama
Publikováno v:
Biochemistry. 42:14284-14292
The known activity of cytochrome P450 46A1 (P450 46A1) is 24(S)-hydroxylation of cholesterol. This reaction produces biologically active oxysterol, 24(S)-hydroxycholesterol, and is also the first step in enzymatic degradation of cholesterol in the br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22540c276e667e9775e351a8e63507c
https://doi.org/10.1021/bi035512f
https://doi.org/10.1021/bi035512f
Publikováno v:
Drug Metabolism and Disposition. 31:1300-1305
Sulfation is an important reaction in the biotransformation of steroid hormones, neurotransmitters, drugs, and other xenobiotics, yet little is known about the effects of organic solvents on sulfotransferase (SULT) activities in vitro. Initial experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d02f3cb2a7443501f51703fd0c8fed2
https://doi.org/10.1124/dmd.31.11.1300
https://doi.org/10.1124/dmd.31.11.1300
Autor:
Yuh Lin, Ryan Norcross, Magang Shou, Thomas H. Rushmore, Yinghe Li, A. David Rodrigues, Qin Mei, Ping Lu, Grit Sandig
Publikováno v:
Drug Metabolism and Disposition. 31:1161-1169
Seven dog cytochromes P450 (P450s) were heterologously expressed in baculovirus-Sf21 insect cells. Of all enzymes examined, CYP1A1 exhibited high 7-ethoxyresorufin O -deethylase activity (low K m enzyme, 1 μM). CYP2B11 and CYP3A12 effectively cataly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0dc02b0aa8e42a0f7da102afa43f0e0
https://doi.org/10.1124/dmd.31.9.1161
https://doi.org/10.1124/dmd.31.9.1161