High specificity of engineered T cells with third generation CAR (CD28-4-1BB-CD3-ζ) based on biotin-bound monomeric streptavidin for potential tumor immunotherapy

Autor: Jorge Gallego-Valle, Verónica Astrid Pérez-Fernández, Jesús Rosales-Magallares, Sergio Gil-Manso, María Castellá, Europa Azucena Gonzalez-Navarro, Rafael Correa-Rocha, Manel Juan, Marjorie Pion

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionImmunotherapy has revolutionized cancer treatment, and Chimeric Antigen Receptor T cell therapy (CAR-T) is a groundbreaking approach. Traditional second-generation CAR-T therapies have achieved remarkable success in hematological malignan

Externí odkaz: https://doaj.org/article/d613b6479ed44a07b48cd00d01b1c9e2

Diagnostic accuracy of serum calprotectin measured by CLIA and EIA in juvenile idiopathic arthritis: a proof-of-concept study

Autor: Helena Codes-Méndez, Berta Magallares-López, Hye-Sang Park, Anaís Mariscal, Cándido Juárez, Susana Boronat, Laura Martínez-Martínez, Hector Corominas

Publikováno v: Frontiers in Pediatrics, Vol 12 (2024)

ObjectiveC-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are used to assess disease activity in juvenile idiopathic arthritis (JIA). However, because these biomarkers do not always differentiate between active and inactive disease,

Externí odkaz: https://doaj.org/article/542a2c6fd7d3429e9cb1012732cceec7

Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER register

Autor: Santos Castañeda, Ricardo Blanco, Héctor Corominas, Patricia Carreira, Ivan Castellví, Eugenio De Miguel, Javier Narváez, Judit LLuch, Ivette Casafont-Solé, Jose María Pego, Lydia Abasolo, Carmen Larena, Francisco Ortiz-Sanjuán, Clara Moriano Morales, Elvira Díez Álvarez, Miguel Ángel González-Gay, Berta Magallares, Monica Ibañez Barcelo, Laura Garrido Courel, Vanesa Hernandez Hernandez, Patricia Moya Alvarado, Anne Riveros Frutos, Margarida Vasques Rocha, María Alcalde Villar, Antonio Juan Mas, Julio Sanchez, Joan Calvet, Clara Molina Almela, Amalia Rueda Cid, Cristina Campos Fernández, Carmen Riesco Bárcena, Patricia Moran Alvarez, Judit Font Urgelles, Alejandro Muñoz Jiménez, Delia Fernández-Lozano, Iñigo Hernández-Rodríguez, Marta Domínguez-Álvaro, Maite Silva-Díaz, Joaquín María Belzunegui, Eva Galíndez-Agirregoikoa, Vicente Aldaroso, Javier Loricera, Noemi Garrido-Puñal, Vanessa Andrea Navarro, Tarek Carlos Salman Monte, Trinidad Pérez Sandoval, Ismael González Fernández, Javier Mendizábal-Mateos, María Concepción Fito Manteca, Natividad del Val del Amo, Loreto Horcada Rubio, Inmaculada Paniagua Zudaire, Ricardo Gutiérrez Polo, Juliana Restrepo Vélez, Eduardo Loza Cortina, Elisa Fernández Fernández, Tomás Almorza, Leticia Léon Mateos, Luis Rodríguez Rodríguez, Pia Mercedes Lois Bermejo, Selene Labrada Arrabal, Susana Holgado Pérez, Jordi Camins, Javier Calvo Catalá, Rafael Benito Melero, Francisco Maceiras, Nair Pérez, Ceferino Barbazán, Irena Altabás, John Guzman, Paula Valentina Estrada Alarcón, Ana Milena Millán, AnaF Cruz Valenciano, Félix Cabero del Pozo, AnaBelén Rodríguez Cambrón, Cristina Macia Villa, Inmaculada Ros Vilamajó, Elide Toniolo, Ana Paula Cacheda, María Sagrario Bustabad Reyes, María García González, Alicia García Dorta, Jaime Calvo Allen, Miren Uriarte-Ecenarro, Cristina Valero Martínez, Esther F Vicente Rabaneda, Carlos García Porrúa, Carlota Laura Iñiguez Ubiaga, Noelia Álvarez Rivas, Tomás Ramón Vázquez Rodríguez, José Alberto Miranda Filloy, Amalia Sánchez-Andrade Fernández, Carlos Galisteo Lencastre Da Veiga, María Jesús García Villanueva, Marina Tortosa Cabañas, Marta Serrano Warleta, Aliuska Palomeque Vargas, Alberto Ruiz Román, Clara Aguilera Cros, JoséA Román Ivorra, Anderson Huaylla, Itziar Calvo Zorrilla, Jesús A Valero-Jaimes, Luis López Domínguez, Cesar Antonio Egues Dubuc, Lucia Silva Fernández

Publikováno v: RMD Open, Vol 10, Iss 1 (2024)

Objective This study aimed to estimate the incidence of giant cell arteritis (GCA) in Spain and to analyse its clinical manifestations, and distribution by age group, sex, geographical area and season.Methods We included all patients diagnosed with G

Externí odkaz: https://doaj.org/article/e9f8b06cb9dc42eb8922f2097ea3286a

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Polymorphisms indicating risk of inflammatory bowel disease or antigenicity to anti-TNF drugs as biomarkers of response in children

Autor: Zapata-Cobo, Paula ^a, Salvador-Martín, Sara ^a, Velasco, Marta ^b, Palomino, Laura M. ^b, Clemente, Susana ^c, Segarra, Oscar ^c, Moreno-Álvarez, Ana ^d, Fernández-Lorenzo, Ana ^d, Pérez-Moneo, Begoña ^e, Montraveta, Montserrat ^f, Sánchez, Cesar ^a, Tolín, Mar ^a, Loverdos, Inés ^g, Fobelo, María Jesús ^h, Navas-López, Victor Manuel ⁱ, Magallares, Lorena ^j, García-Romero, Ruth ^k, Sánchez-Hernández, José Germán ^l, Rodríguez, Alejandro ^m, Bossacoma, Ferrán ⁿ, Balboa, María Jesús ^o, Salcedo, Enrique ^p, Sanjurjo-Sáez, María ^a, López-Fernández, Luis A. ^{a, ⁎}

Publikováno v: In Pharmacological Research August 2023 194