Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Magalie Géraldy"'
Autor:
Nicholas J. Porter, Jeremy D. Osko, Ina Oehme, Olaf Witt, Johannes Ridinger, David W. Christianson, Peter Sehr, Corey J Herbst-Gervasoni, Aubry K. Miller, Magalie Géraldy, Lars Hellweg, Michael Morgen, Raphael R. Steimbach, Nikolas Gunkel
Publikováno v:
ChemMedChem
We report the synthesis and evaluation of a class of selective multitarget agents for the inhibition of HDAC6, HDAC8, and HDAC10. The concept for this study grew out of a structural analysis of the two selective inhibitors Tubastatin A (HDAC6/10) and
Autor:
Raphael R. Steimbach, Ina Oehme, Gernot Poschet, Gergely Tihanyi, Aubry K. Miller, Nikolas Gunkel, Johannes Ridinger, David W. Christianson, Corey J Herbst-Gervasoni, Magalie Géraldy, Glynis Klinke
We report the first selective chemical probes for histone deacetylase 10 (HDAC10) with unprecedented selectivity over other HDAC isozymes. HDAC10 deacetylates polyamines and has a distinct substrate specificity, making it unique among the 11 zinc-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::361de7a04f1ff4e7e71f3beffc2bd38c
https://doi.org/10.33774/chemrxiv-2021-37shs
https://doi.org/10.33774/chemrxiv-2021-37shs
Autor:
Raphael R. Steimbach, Corey J. Herbst-Gervasoni, Glynis Klinke, Magalie Géraldy, Gergely Tihanyi, Johannes Ridinger, Gernot Poschet, Ina Oehme, David W. Christianson, Nikolas Gunkel, Aubry K. Miller
We report the first selective chemical probes for histone deacetylase 10 (HDAC10) with unprecedented selectivity over other HDAC isozymes. HDAC10 deacetylates polyamines and has a distinct substrate specificity, making it unique among the 11 zinc-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34bc7325896891d199b54816f79f143c
https://doi.org/10.26434/chemrxiv-2021-37shs
https://doi.org/10.26434/chemrxiv-2021-37shs
Autor:
Raphael R. Steimbach, Olaf Witt, Peter Sehr, Oliver Koch, Johannes Ridinger, Nikolas Gunkel, Ina Oehme, Mauro Oddo Nogueira, Magalie Géraldy, Michael Morgen, Davide Moi, Mona Malz, Aubry K. Miller
Publikováno v:
Journal of Medicinal Chemistry. 62:4426-4443
The discovery of isozyme-selective histone deacetylase (HDAC) inhibitors is critical for understanding the biological functions of individual HDACs and for validating HDACs as drug targets. The isozyme HDAC10 contributes to chemotherapy resistance an
Autor:
Magalie Géraldy, Karel D. Klika, Raphael R. Steimbach, Alicja Wzorek, Gergely Tihanyi, Aubry K. Miller
Publikováno v:
Symmetry, Vol 13, Iss 1753, p 1753 (2021)
Symmetry
Volume 13
Issue 9
Symmetry
Volume 13
Issue 9
Nitrogen-inversion rates and diffusion coefficients were measured using 1H NMR for 14 drug-like molecules. The slow nitrogen-inversion rates interconverting the enantiomers of these molecules lay within a postulated intermediate range in terms of the
Autor:
Mona Malz, Aubry K. Miller, Nikolas Gunkel, Oliver Koch, Mauro S. Nogueira, Olaf Witt, Ina Oehme, Johannes Ridinger, Raphael R. Steimbach, Peter Sehr, Michael Morgen, Magalie Géraldy
The discovery of isozyme-selective histone deacetylase (HDAC) inhibitors is critical for understanding the biological functions of individual HDACs and for validating HDACs as clinical drug targets. The isozyme HDAC10 contributes to chemotherapy resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1a8d93f14f8e0cfcab9c9c7d8adb20
https://doi.org/10.26434/chemrxiv.7406618.v1
https://doi.org/10.26434/chemrxiv.7406618.v1