Supplementary Figure 2 from First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer

Autor: Olivier Cuvillier, Bernard Malavaud, Magalie Bocquet, Catherine Mazerolles, Isabelle Ader, Leyre Brizuela

PDF file, 107K, The modulation of S1P content in C4-2B prostate cancer cells alters sensitivity to irradiation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff48a056c3ae4c9b204eb15aac7c59a
https://doi.org/10.1158/1535-7163.22498693

Supplementary Figure 1 from First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer

Autor: Olivier Cuvillier, Bernard Malavaud, Magalie Bocquet, Catherine Mazerolles, Isabelle Ader, Leyre Brizuela

PDF file, 129K, PC-3 overexpressing-SPL cell lines exhibit a lower rate of cell viability associated with enhanced basal apoptosis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e88da28d8ed2ad02f4068c9c6efffb9
https://doi.org/10.1158/1535-7163.22498696

Supplementary Figure 4 from First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer

Autor: Olivier Cuvillier, Bernard Malavaud, Magalie Bocquet, Catherine Mazerolles, Isabelle Ader, Leyre Brizuela

PDF file, 78K, S1P degradation products do not sensitize to radiotherapy or chemotherapy in PC-3 and C4-2B prostate cancer cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68862972208ac68530ac1cefaba846f
https://doi.org/10.1158/1535-7163.22498687

Sphingosine 1-phosphate signaling through its receptor S1P5 promotes chromosome segregation and mitotic progression

Autor: Roger A. Sabbadini, Guillaume Andrieu, Olivier Cuvillier, Thierry Walzer, Sophie Branka, Magalie Bocquet, Kousuke Kasahara, Adeline Ledoux, Masaki Inagaki, Julia Gilhodes, Anastassia Hatzoglou

Publikováno v: Science Signaling
Science Signaling, 2017, 10 (472), ⟨10.1126/scisignal.aah4007⟩
Science Signaling, American Association for the Advancement of Science, 2017, 10 (472), ⟨10.1126/scisignal.aah4007⟩

International audience; Sphingosine kinase 1 (SphK1) promotes cell proliferation and survival, and its abundance is often increased in tumors. SphK1 produces the signaling lipid sphingosine 1-phosphate (S1P), which activates signaling cascades downst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cdebd587817680cae5c322c99049dc
https://hal.science/hal-01911204

First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer

Autor: Olivier Cuvillier, Magalie Bocquet, Bernard Malavaud, Catherine Mazerolles, Leyre Brizuela, Isabelle Ader

Publikováno v: Molecular cancer therapeutics. 11(9)

This is the first report of sphingosine 1-phosphate lyase (SPL) protein expression and enzymatic activity in human neoplasm. This enzyme drives irreversible degradation of sphingosine 1-phosphate (S1P), a bioactive lipid associated with resistance to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c8b8283368b72a916217fd62cd1bfe
https://pubmed.ncbi.nlm.nih.gov/22784711