Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Magali Saez-Ayala"'
Autor:
Magali Saez-Ayala, Laurent Hoffer, Sébastien Abel, Khaoula Ben Yaala, Benoit Sicard, Guillaume P. Andrieu, Mehdi Latiri, Emma K. Davison, Marco A. Ciufolini, Paul Brémond, Etienne Rebuffet, Philippe Roche, Carine Derviaux, Edwige Voisset, Camille Montersino, Remy Castellano, Yves Collette, Vahid Asnafi, Stéphane Betzi, Patrice Dubreuil, Sébastien Combes, Xavier Morelli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Cancer cells utilize the main de novo pathway and the alternative salvage pathway for deoxyribonucleotide biosynthesis to achieve adequate nucleotide pools. Deoxycytidine kinase is the rate-limiting enzyme of the salvage pathway and it has r
Externí odkaz:
https://doaj.org/article/455ce64ed58b44c582373ae5edcfa6e5
Autor:
Magali Saez-Ayala, Elsie Laban Yekwa, Mauro Carcelli, Bruno Canard, Karine Alvarez, François Ferron
Publikováno v:
IUCrJ, Vol 5, Iss 2, Pp 223-235 (2018)
The Arenaviridae family, together with the Bunyaviridae and Orthomyxoviridae families, is one of the three negative-stranded RNA viral families that encode an endonuclease in their genome. The endonuclease domain is at the N-terminus of the L protein
Externí odkaz:
https://doaj.org/article/441ade17680f410fa3b418e13e4610de
Autor:
Kahina Hammam, Magali Saez-Ayala, Etienne Rebuffet, Laurent Gros, Sophie Lopez, Berengere Hajem, Martine Humbert, Emilie Baudelet, Stephane Audebert, Stephane Betzi, Adrien Lugari, Sebastien Combes, Sebastien Letard, Nathalie Casteran, Colin Mansfield, Alain Moussy, Paulo De Sepulveda, Xavier Morelli, Patrice Dubreuil
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Masitinib is a protein kinase inhibitor that sensitises refractory pancreatic adenocarcinoma cells to treatment with the nucleoside analog gemcitabine. Here the authors show that Masitinib activates deoxycytidine kinase to enhance phosphorylation of
Externí odkaz:
https://doaj.org/article/17f65d9ef23b487fb909bb37564ae125
Autor:
Kendall Carrasco, Camille Montersino, Carine Derviaux, Magali Saez-Ayala, Laurent Hoffer, Audrey Restouin, Rémy Castellano, Justine Casassa, Philippe Roche, Eddy Pasquier, Sébastien Combes, Xavier Morelli, Yves Collette, Stéphane Betzi
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2022, pp.acs.jmedchem.1c02168. ⟨10.1021/acs.jmedchem.1c02168⟩
Journal of Medicinal Chemistry, 2022, pp.acs.jmedchem.1c02168. ⟨10.1021/acs.jmedchem.1c02168⟩
Differentially screening the Fr-PPIChem chemical library on the BET BRD4-BDII versus -BDI bromodomains led to the discovery of a BDII selective tetrahydropyridothienopyrimidinone (THPTP)-based compound. Structure-activity relationship (SAR) and hit-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0378e958b388b76b3d8b2be970b66b5e
https://hal.science/hal-03624836
https://hal.science/hal-03624836
Autor:
Magali Saez-Ayala, François Ferron, Dominga Rogolino, Elsie Laban Yekwa, Loic Roux, Clémence Mondielli, Sergio Hernández, Karine Alvarez, Bruno Canard, Fabrice Bailly, Philippe Cotelle
Publikováno v:
Antiviral Research
Antiviral Research, Elsevier Masson, 2019, 162, pp.79-89. ⟨10.1016/j.antiviral.2018.12.008⟩
Antiviral Research, 2019, 162, pp.79-89. ⟨10.1016/j.antiviral.2018.12.008⟩
Antiviral Research, Elsevier Masson, 2019, 162, pp.79-89. ⟨10.1016/j.antiviral.2018.12.008⟩
Antiviral Research, 2019, 162, pp.79-89. ⟨10.1016/j.antiviral.2018.12.008⟩
International audience; Arenaviridae is a viral family whose members are associated with rodent-transmitted infections to humans responsible of severe diseases. The current lack of a vaccine and limited therapeutic options make the development of eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea4befda3233c7b89ddb4c2a15ac137
https://hal-amu.archives-ouvertes.fr/hal-02612507
https://hal-amu.archives-ouvertes.fr/hal-02612507
Autor:
Laurent Gros, Stephane Betzi, Paulo De Sepulveda, Nathalie Casteran, Magali Saez-Ayala, Martine Humbert, Stéphane Audebert, Kahina Hammam, Patrice Dubreuil, Alain Moussy, Sébastien Combes, Etienne Rebuffet, Adrien Lugari, Sébastien Letard, Colin Mansfield, Sophie Lopez, Berengere Hajem, Emilie Baudelet, Xavier Morelli
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8 (1), ⟨10.1038/s41467-017-01582-5⟩
Nature Communications, 2017, 8 (1), ⟨10.1038/s41467-017-01582-5⟩
'Nature Communications ', vol: 8, pages: 1420-1-120-11 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications, Nature Publishing Group, 2017, 8 (1), ⟨10.1038/s41467-017-01582-5⟩
Nature Communications, 2017, 8 (1), ⟨10.1038/s41467-017-01582-5⟩
'Nature Communications ', vol: 8, pages: 1420-1-120-11 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Masitinib, a highly selective protein kinase inhibitor, can sensitise gemcitabine-refractory cancer cell lines when used in combination with gemcitabine. Here we report a reverse proteomic approach that identifies the target responsible for this sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736ab0c1b51a55de7df23e88f8a422fb
https://hal.archives-ouvertes.fr/hal-01643359/file/article55.pdf
https://hal.archives-ouvertes.fr/hal-01643359/file/article55.pdf
Autor:
Magali, Saez-Ayala, Elsie Laban, Yekwa, Mauro, Carcelli, Bruno, Canard, Karine, Alvarez, François, Ferron
Publikováno v:
IUCrJ
Crystal structures of the endonuclease domain of Lymphocytic choriomeningitis virus (LCMV) in complex with two diketo-acid (DKA) compounds were determined. Based on these data and activity assays, two new DKAs with good affinity for the LCMV endonucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ba5ad5b4bd91c155afeed64828637f6
https://pubmed.ncbi.nlm.nih.gov/29765612
https://pubmed.ncbi.nlm.nih.gov/29765612
Autor:
Jose Neptuno Rodriguez-Lopez, Juan Cabezas-Herrera, María Fernanda Montenegro, Magali Saez Ayala, Luis Sanchez del Campo, MARÍA PIEDAD FERNÁNDEZ PÉREZ
Publikováno v:
Oncogene. 34:135-143
Cancer is characterized by uncontrolled cell growth and the acquisition of metastatic properties. In most cases, the activation of oncogenes and/or deactivation of tumour suppressor genes lead to uncontrolled cell cycle progression and inactivation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73b58e4e03f2b9dba055fe7ff51eeb3
https://doi.org/10.1038/onc.2013.605
https://doi.org/10.1038/onc.2013.605
Publikováno v:
Antiviral Research
Antiviral Research, Elsevier Masson, 2015, 117, pp.122-131. ⟨10.1016/j.antiviral.2015.03.003⟩
Antiviral Research, 2015, 117, pp.122-131. ⟨10.1016/j.antiviral.2015.03.003⟩
Antiviral Research, Elsevier Masson, 2015, 117, pp.122-131. ⟨10.1016/j.antiviral.2015.03.003⟩
Antiviral Research, 2015, 117, pp.122-131. ⟨10.1016/j.antiviral.2015.03.003⟩
The acyclic nucleosides thiophosphonates (9-[2-(thiophosphonomethoxy)ethyl]adenine (S-PMEA) and (R)-9-[2-(thiophosphonomethoxy)propyl]adenine (S-PMPA), exhibit antiviral activity against HIV-1, -2 and HBV. Their diphosphate forms S-PMEApp and S-PMPAp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566cb9e3197dda4cf724c685c761771d
https://hal.archives-ouvertes.fr/hal-01439000
https://hal.archives-ouvertes.fr/hal-01439000
Autor:
Jose Neptuno Rodriguez-Lopez, Juan Cabezas-Herrera, María Fernanda Montenegro, Magali Saez Ayala, Antonio Piñero-Madrona
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52231 (2012)
PLoS ONE
PLoS ONE
BackgroundTumour suppressor genes are often transcriptionally silenced by promoter hypermethylation, and recent research has implicated alterations in chromatin structure as the mechanistic basis for this repression. In addition to DNA methylation, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9355d942eecffc5a2cc74a058296dbb0
https://doi.org/10.1371/journal.pone.0052231
https://doi.org/10.1371/journal.pone.0052231