Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

Autor: Céline Zimmer, Magali Macchi, Kay Grobe, Anna Williams, Elitsa Peeva, Pascale Durbec, Bilal El Waly, Friedemann Kiefer, Myriam Cayre, Béatrice Brousse, Sarah Jaekel, Karine Magalon

Publikováno v: eLife
eLife, 2020, 9, ⟨10.7554/eLife.51735⟩
eLife, Vol 9 (2020)
eLife, eLife Sciences Publication, 2020, 9, ⟨10.7554/eLife.51735⟩
Macchi, M, Magalon, K, Zimmer, C, Peeva, E, El Waly, B, Brousse, B, Jaekel, S, Grobe, K, Kiefer, F, Williams, A C, Cayre, M & Durbec, P 2020, ' Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulphate production ', eLIFE . https://doi.org/10.7554/eLife.51735
Macchi, M, Magalon, K, Zimmer, C, Peeva, E, El Waly, B, Brousse, B, Jaekel, S, Grobe, K, Kiefer, F, Williams, A, Cayre, M & Durbec, P 2020, ' Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production ', eLIFE, vol. 9, e51735 . https://doi.org/10.7554/eLife.51735

International audience; Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7333643a51e881446ae813238339f9
https://hal.science/hal-02993047/document

Oligodendrogenesis in the normal and pathological central nervous system

Autor: Magali Macchi, Myriam Cayre, Pascale Durbec, Bilal El Waly

Publikováno v: Frontiers in Neuroscience, Vol 8 (2014)
Frontiers in Neuroscience

Oligodendrocytes (OLGs) are generated late in development and myelination is thus a tardive event in the brain developmental process. It is however maintained whole life long at lower rate, and myelin sheath is crucial for proper signal transmission

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7c0bbd139c68990d1cf3f4c00b1a28
https://doi.org/10.3389/fnins.2014.00145

Commentary

Autor: Roger W. Jelliffe, Magali Macchi-Andanson, Bruno Charpiat, Christian Ducerf, Jacques Baulieux, Nadine Fourcade

Publikováno v: Therapeutic Drug Monitoring. 24:573-574

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce34fa0f879498ff995072a9fc6a2cd9
https://doi.org/10.1097/00007691-200208000-00020