Výsledky vyhledávání - "Magali Fradet"

Akademický článek

Link between the EZH2 noncanonical pathway and microtubule organization center polarization during early T lymphopoiesis

Autor: Frederique Deshayes, Magali Fradet, Sandra Kaminski, Mireille Viguier, Jean-Pol Frippiat, Stephanie Ghislin

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract EZH2 plays an essential role at the β-selection checkpoint of T lymphopoiesis by regulating histone H3 lysine 27 trimethylation (H3K27me3) via its canonical mode of action. Increasing data suggest that EZH2 could also regulate other cellula

Externí odkaz: https://doaj.org/article/3c278066f76d49198367ef3cae2a915e

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Akademický článek

c-Myc dysregulation is a co-transforming event for nuclear factor-κB activated B cells

Autor: Amandine David, Nicolas Arnaud, Magali Fradet, Hélène Lascaux, Catherine Ouk-Martin, Nathalie Gachard, Ursula Zimber-Strobl, Jean Feuillard, Nathalie Faumont

Publikováno v: Haematologica, Vol 102, Iss 5 (2017)

While c-Myc dysregulation is constantly associated with highly proliferating B-cell tumors, nuclear factor (NF)-κB addiction is found in indolent lymphomas as well as diffuse large B-cell lymphomas, either with an activated B-cell like phenotype or

Externí odkaz: https://doaj.org/article/2bdea7433ec941de88401744e3e458f5

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Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota That Protects From Metabolic Diseases

Publikováno v: Diabetes
Diabetes, American Diabetes Association, 2021, 70 (9), pp.2067-2080. ⟨10.2337/db20-1177⟩
Diabetes, 2021, 70 (9), pp. 2067-2080. ⟨10.2337/db20-1177⟩
Diabetes, American Diabetes Association, 2021, 70 (9), p. 2067-2080. ⟨10.2337/db20-1177⟩

Excess of chronic contact between microbial motifs and intestinal immune cells are known to trigger a low-grade inflammation involved in many pathologies such as obesity and diabetes.The important skewing of intestinal adaptive immunity in the contex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eabb0e1ff67f9175eaa00c8fcf92f6b
https://doi.org/10.2337/db20-1177

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Type 2 diabetes is associated with impaired jejunal enteroendocrine GLP-1 cell lineage in human obesity

Autor: Juan de Toro-Martín, Patricia Serradas, Agnès Ribeiro, Céline Osinski, Laurent Genser, Corinne Blugeon, Armelle Leturque, Laurent Jourdren, Magali Fradet, Edwige Ludiwyne Hubert, Karine Clément, Christine Poitou, Léa Le Gléau, Hédi Soula

Publikováno v: International Journal of Obesity (2005)
International Journal of Obesity
International Journal of Obesity, 2021, ⟨10.1038/s41366-020-00694-1⟩
International Journal of Obesity, Nature Publishing Group, In press, ⟨10.1038/s41366-020-00694-1⟩

Objectives Altered enteroendocrine cell (EEC) function in obesity and type 2 diabetes is not fully understood. Understanding the transcriptional program that controls EEC differentiation is important because some EEC types harbor significant therapeu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da11922e41fa1c8290384bc5cb89df7d
http://europepmc.org/articles/PMC7752761

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Endosomal Confinement of Gold Nanospheres, Nanorods, and Nanoraspberries Governs Their Photothermal Identity and Is Beneficial for Cancer Cell Therapy

Autor: Laurence Motte, Anouchka Plan Sangnier, Magali Fradet, Aurore Van de Walle, Claire Wilhelm, Romain Aufaure, Yoann Lalatonne, Erwann Guénin

Publikováno v: Advanced Biosystems
Advanced Biosystems, Wiley-VCH, 2020, 4 (4), pp.1900284. ⟨10.1002/adbi.201900284⟩

Gold nanoparticles can act as photothermal agents to generate local tumor heating and subsequent depletion upon laser exposure. Herein, photothermal heating of four gold nanoparticles and the resulting induced cancer cell death are systematically ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4fa5a923c809b9c9110d3e63bbdfb19

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A PDGFRα-Mediated Switch toward CD9high Adipocyte Progenitors Controls Obesity-Induced Adipose Tissue Fibrosis

Autor: Judith Aron-Wisnewsky, Marc Ambrosini, Véronique Pelloux, Magali Fradet, Corneliu Henegar, Jean-Sébastien Hulot, Geneviève Marcelin, Raphael Nail-Barthelemy, Adaliene Versiani Matos Ferreira, Christine Rouault, Jean Christophe Bichet, Yuejun Liu, Christine Poitou, Yair Botbol, Karine Clément, Michael Atlan, Emmanuel L. Gautier, Adriana Torcivia

Publikováno v: Cell Metabolism. 25:673-685

Obesity-induced white adipose tissue (WAT) fibrosis is believed to accelerate WAT dysfunction. However, the cellular origin of WAT fibrosis remains unclear. Here, we show that adipocyte platelet-derived growth factor receptor-α-positive (PDGFRα+) p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e04338d8dcba8a17b295f43b339c070a
https://doi.org/10.1016/j.cmet.2017.01.010

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Photothermal Therapy: Endosomal Confinement of Gold Nanospheres, Nanorods, and Nanoraspberries Governs Their Photothermal Identity and Is Beneficial for Cancer Cell Therapy (Adv. Biosys. 4/2020)

Autor: Romain Aufaure, Aurore Van de Walle, Anouchka Plan Sangnier, Erwann Guénin, Magali Fradet, L. Motte, Yoann Lalatonne, Claire Wilhelm

Publikováno v: Advanced Biosystems. 4:2070042

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2553ba7a45756921fac1f3ed302955ad
https://doi.org/10.1002/adbi.202070042

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Mucosal-associated invariant T (MAIT) cells are depleted and prone to apoptosis in cardiometabolic disorders

Autor: Karen E. Assmann, Richard Isnard, Agnès Lehuen, Sothea Touch, Christine Rouault, Christine Poitou, Florian Marquet, Héléna Mosbah, Judith Aron-Wisnewsky, Sébastien André, Karine Clément, Magali Fradet, Gérard Helft

Publikováno v: FASEB Journal
FASEB Journal, 2018, pp.fj201800052RR. ⟨10.1096/fj.201800052RR⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2018, pp.fj201800052RR. ⟨10.1096/fj.201800052RR⟩

The disruption of systemic immune homeostasis is a key mediator in the progression of cardiometabolic diseases (CMDs). We aimed to extend knowledge regarding the clinical relevance of CMD-associated variation of circulating mucosal-associated invaria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59ad211bbd76ed1bdccd6fe373a29f0
https://www.hal.inserm.fr/inserm-02380779

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P-Body Purification Reveals the Condensation of Repressed mRNA Regulons

Autor: Zhou Yi, Magali Fradet, Maïté Courel, Edouard Bertrand, Dominique Weil, Marianne Bénard, Michèle Ernoult-Lange, Sylvie Souquere, Racha Chouaib, Annie Munier, Julien Mozziconacci, Maëlle Daunesse, Jean-Baptiste Morlot, Arnaud Hubstenberger, Gérard Pierron, Michel Kress

Publikováno v: Molecular Cell
Molecular Cell, Cell Press, 2017, 68 (1), pp.144-157.e5. ⟨10.1016/j.molcel.2017.09.003⟩
Molecular Cell, Elsevier, 2017, 68 (1), pp.144-157.e5. ⟨10.1016/j.molcel.2017.09.003⟩
Molecular Cell, 2017, 68 (1), pp.144-157.e5. ⟨10.1016/j.molcel.2017.09.003⟩

Summary Within cells, soluble RNPs can switch states to coassemble and condense into liquid or solid bodies. Although these phase transitions have been reconstituted in vitro, for endogenous bodies the diversity of the components, the specificity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9dabe79e81bb238a94633ce29e99b5f
https://hal.archives-ouvertes.fr/hal-02153054

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Atrial natriuretic peptide regulates adipose tissue accumulation in adult atria

Autor: Thomas Moore-Morris, Stéphane N. Hatem, Magali Fradet, Pascal Leprince, Michel Pucéat, Catherine Rucker-Martin, Karine Clément, Patrick Farahmand, Nadine Suffee, Geneviève Derumeaux, Isabelle Dugail, Gilles Dilanian, Daigo Sawaki

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (5), pp.E771-E780. ⟨10.1073/pnas.1610968114⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (5), pp.E771-E780. ⟨10.1073/pnas.1610968114⟩

International audience; The abundance of epicardial adipose tissue (EAT) is associated with atrial fibrillation (AF), the most frequent cardiac arrhythmia. However, both the origin and the factors involved in EAT expansion are unknown. Here, we found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435247545d228e0651499347a5ffabdc
https://amu.hal.science/hal-01785315/document

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