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pro vyhledávání: '"Magali Demoor-Fossard"'
Autor:
Françoise Rédini, Renato V. Iozzo, Philippe Galéra, Jean-Pierre Pujol, Magali Demoor-Fossard, Manoranjan Santra
Publikováno v:
Journal of Biological Chemistry. 276:36983-36992
Decorin, a small leucine-rich proteoglycan may play an important role in the attempt of cartilage repair initiated by chondrocytes in early stages of osteoarthritis, through its ability to bind collagen fibrils and growth factors such as transforming
Publikováno v:
Molecular and Cellular Biochemistry. 199:69-80
Small proteoglycans (PGs) are supposed to play great roles in the assembly of cartilage matrix but the influence of cytokines and growth factors on their synthesis by articular chondrocytes is largely unknown. We investigated whether EL-1 and TGFβ1
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1398:179-191
In this study, the levels of mRNAs coding for aggrecan, decorin and biglycan in rabbit articular chondrocytes were investigated, using both monolayer and 3D-alginate cultures treated with TGF-β1 and IL-1β. The cells were shown to express higher amo
Publikováno v:
Biochimica et biophysica acta. 1355(1)
Cell-surface proteoglycans (PGs) were extracted with Triton X-100 from rabbit articular chondrocytes cultured in monolayers and in alginate beads. They were first purified on DEAE-Trisacryl columns and the proportion of hydrophobic PGs was determined