Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone

Autor: Mohamed Habbeddine, Christophe Verthuy, Olivia Rastoin, Lionel Chasson, Magali Bebien, Marc Bajenoff, Sahil Adriouch, Joke M.M. den Haan, Josef M. Penninger, Toby Lawrence

Publikováno v: Cell Reports, Vol 21, Iss 9, Pp 2515-2527 (2017)

The spleen plays an important role in protective immunity to bloodborne pathogens. Macrophages and dendritic cells (DCs) in the spleen marginal zone capture microbial antigens to trigger adaptive immune responses. Marginal zone macrophages (MZMs) can

Externí odkaz: https://doaj.org/article/705661bb2792462fb2dbd272b8be592d

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression

Autor: Nathalie Auphan-Anezin, Marion Massé, Thomas Ulas, Juan Rodriguez-Vita, Pieter Goossens, Christophe Verthuy, Anders Etzerodt, Marc Dalod, Magali Bebien, Olivia Rastoin, Martin R Turner, Joachim L. Schultze, Olympia Papantonopoulou, Miranda Van Eck, Toby Lawrence, Thien Phong Vu Manh, Victoire Gouirand

Publikováno v: Cell Metabolism
Cell Metabolism, Elsevier, 2019, 29 (6), pp.1376-1389. ⟨10.1016/j.cmet.2019.02.016⟩
Goossens, P, Rodriguez-Vita, J, Etzerodt, A, Masse, M, Rastoin, O, Gouirand, V, Ulas, T, Papantonopoulou, O, Van Eck, M, Auphan-Anezin, N, Bebien, M, Verthuy, C, Vu Manh, T P, Turner, M, Dalod, M, Schultze, J L & Lawrence, T 2019, ' Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression ', CELL METABOLISM, vol. 29, no. 6, pp. 1376-1389.e4 . https://doi.org/10.1016/j.cmet.2019.02.016
Cell Metabolism, Elsevier, 2019, 29 (6), pp.1376-1389.e4. ⟨10.1016/j.cmet.2019.02.016⟩
Goossens, P, Rodriguez-Vita, J, Etzerodt, A, Masse, M, Rastoin, O, Gouirand, V, Ulas, T, Papantonopoulou, O, Van Eck, M, Auphan-Anezin, N, Bebien, M, Verthuy, C, Vu Manh, T P, Turner, M, Dalod, M, Schultze, J L & Lawrence, T 2019, ' Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression ', Cell Metabolism, vol. 29, no. 6, pp. 1376-1389.e4 . https://doi.org/10.1016/j.cmet.2019.02.016
Cell Metabolism, 2019, 29 (6), pp.1376-1389. ⟨10.1016/j.cmet.2019.02.016⟩
Cell Metabolism, 29(6), 1376-1389.e4. Cell Press
Cell metabolism 29(6), 1376-1389.e4 (2019). doi:10.1016/j.cmet.2019.02.016

Macrophages possess intrinsic tumoricidal activity, yet tumor-associated macrophages (TAMs) rapidly adopt an alternative phenotype within the tumor microenvironment that is marked by tumor-promoting immunosuppressive and trophic functions. The mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90bee64f16c403c31b709e0d5a1a96b
https://hal.archives-ouvertes.fr/hal-02359441/document

Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of 'soluble CD163' in plasma

Autor: Mohamed Habbeddine, Ronni R. Plovsing, Holger Jon Møller, Ronan M. G. Berg, Magali Bebien, Morten Andersen, Toby Lawrence, Søren K. Moestrup, Anders Etzerodt

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7, ⟨10.1038/srep40286⟩
Etzerodt, A, Berg, R M G, Plovsing, R R, Andersen, M N, Bebien, M, Habbeddine, M, Lawrence, T, Møller, H J & Moestrup, S K 2017, ' Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of 'soluble CD163' in plasma ', Scientific Reports, vol. 7, pp. 40286 . https://doi.org/10.1038/srep40286
Scientific Reports, Nature Publishing Group, 2017, 7
Scientific Reports, 2017, 7, ⟨10.1038/srep40286⟩
Etzerodt, A, Berg, R M G, Plovsing, R R, Andersen, M N, Bebien, M, Habbeddine, M, Lawrence, T, Møller, H J & Moestrup, S K 2017, ' Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of 'soluble CD163' in plasma ', Scientific Reports, vol. 7, 40286 . https://doi.org/10.1038/srep40286

CD163 is the macrophage receptor for uptake of hemoglobin-haptoglobin complexes. The human receptor can be shed from the macrophage surface owing to a cleavage site for the inflammation-inducible TACE/ADAM17 enzyme. Accordingly, plasma ‘soluble CD1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d930ad17b361a1ac1b9023a77efb0dac
https://hal.archives-ouvertes.fr/hal-01996186

An antiinflammatory role for IKKβ through the inhibition of 'classical' macrophage activation

Autor: David H. Broide, Arnaud Didierlaurent, Toby Lawrence, Ruth Nebauer, Magali Bebien, Tracy Hussell, Carol Ho Yan Fong, Michael Karin

Publikováno v: Journal of Experimental Medicine. 205:1269-1276

The nuclear factor kappaB (NF-kappaB) pathway plays a central role in inflammation and immunity. In response to proinflammatory cytokines and pathogen-associated molecular patterns, NF-kappaB activation is controlled by IkappaB kinase (IKK)beta. Usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fd19a8fce01d359fb10509a7ecf9c14
https://doi.org/10.1084/jem.20080124

Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers

Autor: Dennis C. Otero, Robert C. Rickert, Magali Bebien, Yixue Cao, Giuseppina Bonizzi, Bruce J. Aronow, Gourisankar Ghosh, Anil G. Jegga, Don Vu, Michael Karin, Kirsten E Johnson-Vroom

Publikováno v: The EMBO Journal. 23:4202-4210

IkappaB Kinase (IKK)alpha is required for activation of an alternative NF-kappaB signaling pathway based on processing of the NF-kappaB2/p100 precursor protein, which associates with RelB in the cytoplasm. This pathway, which activates RelB:p52 dimer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5108e98f4ff894cdba007590ec894027
https://doi.org/10.1038/sj.emboj.7600391