Validation of a New Scoring Scale for Behavioral Assessment of L-Dopa-Induced Dyskinesia in the Rat: A New Tool for Early Decision-Making in Drug Development

Autor: Anne-Sophie Denibaud, Magali Alix, Christophe Drieu La Rochelle, Wendy Deffains, Marine Seffals, Pierre Montagne, Simon Loiodice

Publikováno v: ACS Chemical Neuroscience
ACS Chemical Neuroscience, American Chemical Society (ACS), 2018, 9 (4), pp.762-772. ⟨10.1021/acschemneuro.7b00426⟩
ACS Chemical Neuroscience, 2018, 9 (4), pp.762-772. ⟨10.1021/acschemneuro.7b00426⟩
ACS Chemical Neuroscience, American Chemical Society (ACS), In press, 〈10.1021/acschemneuro.7b00426〉

International audience; The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated nonhuman primate (NHP) has been described as the most translatable model for experimental reproduction of L-dopa-induced dyskinesia (LID). However, from a drug di

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https://hal.uca.fr/hal-01693938/document