Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Magali, Toussaint"'
Autor:
Haidy A. Saleh, Nicola Mitwasi, Martin Ullrich, Manja Kubeil, Magali Toussaint, Winnie Deuther-Conrad, Christin Neuber, Claudia Arndt, Liliana R. Loureiro, Alexandra Kegler, Karla Elizabeth González Soto, Birgit Belter, Claudia Rössig, Jens Pietzsch, Marcus Frenz, Michael Bachmann, Anja Feldmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Glioblastoma (GBM) is still an incurable tumor that is associated with high recurrence rate and poor survival despite the current treatment regimes. With the urgent need for novel therapeutic strategies, immunotherapies, especially chimeric antigen r
Externí odkaz:
https://doaj.org/article/869c24c8ece440448383f3d31672b966
Autor:
Barbara Wenzel, Stefan R. Fritzsche, Magali Toussaint, Detlef Briel, Klaus Kopka, Peter Brust, Matthias Scheunemann, Winnie Deuther-Conrad
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1272 (2022)
The cyclic nucleotide phosphodiesterase 2A is an intracellular enzyme which hydrolyzes the secondary messengers cAMP and cGMP and therefore plays an important role in signaling cascades. A high expression in distinct brain areas as well as in cancer
Externí odkaz:
https://doaj.org/article/b7b1f6b818274cb1ba344ecd96fb5720
Autor:
Gabriela Schaffernicht, Qi Shang, Alicia Stievenard, Kai Bötzel, Yanina Dening, Romy Kempe, Magali Toussaint, Daniel Gündel, Mathias Kranz, Heinz Reichmann, Christel Vanbesien-Mailliot, Peter Brust, Marianne Dieterich, Richard H. W. Funk, Ursula Ravens, Francisco Pan-Montojo
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Parkinson's disease (PD) is known to involve the peripheral nervous system (PNS) and the enteric nervous system (ENS). Functional changes in PNS and ENS appear early in the course of the disease and are responsible for some of the non-motor symptoms
Externí odkaz:
https://doaj.org/article/4db44147fd7946ea905f96e0b6ed023b
Autor:
Daniel Gündel, Magali Toussaint, Thu Hang Lai, Winnie Deuther-Conrad, Paul Cumming, Susann Schröder, Rodrigo Teodoro, Rareş-Petru Moldovan, Francisco Pan-Montojo, Bernhard Sattler, Klaus Kopka, Osama Sabri, Peter Brust
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 516 (2022)
The cerebral expression of the A2A adenosine receptor (A2AAR) is altered in neurodegenerative diseases such as Parkinson’s (PD) and Huntington’s (HD) diseases, making these receptors an attractive diagnostic and therapeutic target. We aimed to fu
Externí odkaz:
https://doaj.org/article/e2058fe7ee934c008d6cd4ac33ced1b4
Autor:
Oliver Clauß, Linda Schäker-Hübner, Barbara Wenzel, Magali Toussaint, Winnie Deuther-Conrad, Daniel Gündel, Rodrigo Teodoro, Sladjana Dukić-Stefanović, Friedrich-Alexander Ludwig, Klaus Kopka, Peter Brust, Finn K. Hansen, Matthias Scheunemann
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 324 (2022)
The degree of acetylation of lysine residues on histones influences the accessibility of DNA and, furthermore, the gene expression. Histone deacetylases (HDACs) are overexpressed in various tumour diseases, resulting in the interest in HDAC inhibitor
Externí odkaz:
https://doaj.org/article/830003203e3b458b81afb939ef4979aa
Autor:
Franziska Mitrach, Maximilian Schmid, Magali Toussaint, Sladjana Dukic-Stefanovic, Winnie Deuther-Conrad, Heike Franke, Alexander Ewe, Achim Aigner, Christian Wölk, Peter Brust, Michael C. Hacker, Michaela Schulz-Siegmund
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 326 (2022)
Convection-enhanced delivery (CED) has been introduced as a concept in cancer treatment to generate high local concentrations of anticancer therapeutics and overcome the limited diffusional distribution, e.g., in the brain. RNA interference provides
Externí odkaz:
https://doaj.org/article/a2442b8c8e9d46428d86ea4ed200a1d3
Autor:
Daniel Gündel, Winnie Deuther-Conrad, Lea Ueberham, Sarandeep Kaur, Elina Otikova, Rodrigo Teodoro, Magali Toussaint, Thu Hang Lai, Oliver Clauß, Matthias Scheunemann, Guy Bormans, Michael Bachmann, Klaus Kopka, Peter Brust, Rareş-Petru Moldovan
Publikováno v:
Journal of Medicinal Chemistry. 65:9034-9049
Autor:
Philipp Ulbrich, Lorena Morton, Michael Briese, Naomi Lämmlin, Hendrik Mattern, Md. Hasanuzzaman, Melina Westhues, Mahsima Khoshneviszadeh, Silke Appenzeller, Daniel Gündel, Magali Toussaint, Peter Brust, Torsten Kniess, Anja Oelschlegel, Jürgen Goldschmidt, Sven Meuth, Hans-Jochen Heinze, Grazyna Debska-Vielhaber, Stefan Vielhaber, Axel Becker, Alexander Dityatev, Solveig Jandke, Michael Sendtner, Ildiko Dunay, Stefanie Schreiber
Chronic arterial hypertension causes cerebral microvascular dysfunction and doubles dementia risk in aging. However, cognitive health preservation by therapeutic blood pressure lowering alone is limited and depends on disease duration, the degree of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1099a4ecd522621afe81e01e6f9f610
https://doi.org/10.1101/2023.01.20.524921
https://doi.org/10.1101/2023.01.20.524921
Autor:
Magali Toussaint, Winnie Deuther-Conrad, Mathias Kranz, Steffen Fischer, Friedrich-Alexander Ludwig, Tareq A. Juratli, Marianne Patt, Bernhard Wünsch, Gabriele Schackert, Osama Sabri, Peter Brust
Publikováno v:
Molecules, Vol 25, Iss 9, p 2170 (2020)
Glioblastoma multiforme (GBM) is the most devastating primary brain tumour characterised by infiltrative growth and resistance to therapies. According to recent research, the sigma-1 receptor (sig1R), an endoplasmic reticulum chaperone protein, is in
Externí odkaz:
https://doaj.org/article/cb7e0b2c553e412f8e24162757eecf7b
Autor:
Masoud Sadeghzadeh, Barbara Wenzel, Daniel Gündel, Winnie Deuther-Conrad, Magali Toussaint, Rareş-Petru Moldovan, Steffen Fischer, Friedrich-Alexander Ludwig, Rodrigo Teodoro, Shirisha Jonnalagadda, Sravan K. Jonnalagadda, Gerrit Schüürmann, Venkatram R. Mereddy, Lester R. Drewes, Peter Brust
Publikováno v:
Molecules, Vol 25, Iss 10, p 2309 (2020)
Monocarboxylate transporters 1-4 (MCT1-4) are involved in several metabolism-related diseases, especially cancer, providing the chance to be considered as relevant targets for diagnosis and therapy. [18F]FACH was recently developed and showed very pr
Externí odkaz:
https://doaj.org/article/0dea2432e8824c31a2e76d505164a53f