Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Magali, Irla"'
Autor:
Alexia Borelli, Jérémy C. Santamaria, Cloé Zamit, Cécile Apert, Jessica Chevallier, Philippe Pierre, Rafael J. Argüello, Lionel Spinelli, Magali Irla
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Regulatory T cells (Treg) are critical players of immune tolerance that develop in the thymus via two distinct developmental pathways involving CD25+Foxp3− and CD25−Foxp3lo precursors. However, the mechanisms regulating the recently iden
Externí odkaz:
https://doaj.org/article/45d2e9da70904a42bd5946d002075ce9
Autor:
Ludivine Amable, Luis Antonio Ferreira Martins, Remi Pierre, Marcio Do Cruseiro, Ghita Chabab, Arnauld Sergé, Camille Kergaravat, Marc Delord, Christophe Viret, Jean Jaubert, Chaohong Liu, Saoussen Karray, Julien C. Marie, Magali Irla, Hristo Georgiev, Emmanuel Clave, Antoine Toubert, Bruno Lucas, Jihene Klibi, Kamel Benlagha
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Invariant natural killer T (NKT) cell subsets are defined based on their cytokine-production profiles and transcription factors. Their distribution is different in C57BL/6 (B6) and BALB/c mice, with a bias for NKT1 and NKT2/NKT17 subsets, re
Externí odkaz:
https://doaj.org/article/ba78e7ec48c04cffbaafd46f86a85388
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/c66382ff2d1c4d6ba779595dc7280fcd
Publikováno v:
Bio-Protocol, Vol 13, Iss 21 (2023)
Medullary thymic epithelial cells (mTEC) are bona fide antigen-presenting cells that play a crucial role in the induction of T-cell tolerance. By their unique ability to express a broad range of tissue-restricted self-antigens, mTEC control the clona
Externí odkaz:
https://doaj.org/article/2a9948d47ea04b00913f130d470335c2
Autor:
Aїsha Callebaut, Ylke Bruggeman, Cloé Zamit, Fernanda Marques Câmara Sodré, Magali Irla, Chantal Mathieu, Mijke Buitinga, Lut Overbergh
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Post-translational modifications can lead to a break in immune tolerance in autoimmune diseases such as type 1 diabetes (T1D). Deamidation, the conversion of glutamine to glutamic acid by transglutaminase (TGM) enzymes, is a post-translational modifi
Externí odkaz:
https://doaj.org/article/2d1b545b8d42415fad5446261cee44bf
Publikováno v:
Bio-Protocol, Vol 12, Iss 8 (2022)
Single molecule tracking (SMT) is a powerful technique to study molecular dynamics, and is particularly adapted to monitor the motion and interactions of cell membrane components. Assessing interactions among two molecular populations is classically
Externí odkaz:
https://doaj.org/article/9f23791e32244a5a88be70af5340a9f0
Autor:
Noella Lopes, Nicolas Boucherit, Jérémy C Santamaria, Nathan Provin, Jonathan Charaix, Pierre Ferrier, Matthieu Giraud, Magali Irla
Publikováno v:
eLife, Vol 11 (2022)
Interactions of developing T cells with Aire+ medullary thymic epithelial cells expressing high levels of MHCII molecules (mTEChi) are critical for the induction of central tolerance in the thymus. In turn, thymocytes regulate the cellularity of Aire
Externí odkaz:
https://doaj.org/article/a967244e4d8746a2a75d6f0db2491acc
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
. TGFβ is critical for limiting autoreactive responses of peripheral T cells. Here, the authors show that TGFβ signaling in thymocytes mediates elimination of self-reactive T cells and promotes the expression of self-antigens by medullary thymic ep
Externí odkaz:
https://doaj.org/article/87adb1264ac9462da662d251d3aa3047
Autor:
Markus Niebuhr, Julia Belde, Anke Fähnrich, Arnauld Serge, Magali Irla, Christoph T Ellebrecht, Christoph M Hammers, Katja Bieber, Jürgen Westermann, Kathrin Kalies
Publikováno v:
eLife, Vol 10 (2021)
Follicular T helper cells (Tfh) are a specialized subset of CD4 effector T cells that are crucial for germinal center (GC) reactions and for selecting B cells to undergo affinity maturation. Despite this central role for humoral immunity, only few da
Externí odkaz:
https://doaj.org/article/5c629f812223404cac261caf6eb8a22c
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Foxp3+ regulatory T cells (Treg) maintain the integrity of the organism by preventing excessive immune responses. These cells protect against autoimmune diseases but are also important regulators of other immune responses including inflammation, alle
Externí odkaz:
https://doaj.org/article/88017c15223641cf8c9374d3ec192a68