Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Magali, Berthouze"'
Autor:
Alexandre Lucas, Aude Saulière, George S. Baillie, Anne-Coline Laurent, Céline Galés, Magali Berthouze-Duquesnes, Yuan Yan Sin, Frank Lezoualc'h
Publikováno v:
Cell Signal
Cell Signal, 2013, 25 (4), pp.970-80. ⟨10.1016/j.cellsig.2012.12.007⟩
Cell Signal, 2013, 25 (4), pp.970-80. ⟨10.1016/j.cellsig.2012.12.007⟩
International audience; β1 and β2 adrenergic receptors (βARs) are highly homologous but fulfill distinct physiological and pathophysiological roles. Here we show that both βAR subtypes activate the cAMP-binding protein Epac1, but they differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50921a6ab1201fc63978c7e0932db035
https://doi.org/10.1016/j.cellsig.2012.12.007
https://doi.org/10.1016/j.cellsig.2012.12.007
Publikováno v:
Current Heart Failure Reports
Current Heart Failure Reports, Current Medicine Group, 2011, 8 (3), pp.159-67. ⟨10.1007/s11897-011-0062-8⟩
Current Heart Failure Reports, 2011, 8 (3), pp.159-67. ⟨10.1007/s11897-011-0062-8⟩
Current Heart Failure Reports, Current Medicine Group, 2011, 8 (3), pp.159-67. ⟨10.1007/s11897-011-0062-8⟩
Current Heart Failure Reports, 2011, 8 (3), pp.159-67. ⟨10.1007/s11897-011-0062-8⟩
International audience; Cyclic adenosine 3',5'-monophosphate (cAMP) mediates the biological effects of various hormones and neurotransmitters. Stimulation of cardiac β-adrenergic receptors (β-AR) via catecholamines leads to activation of adenylyl c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221d1c08e14fef9f392a224609aabe06
https://doi.org/10.1007/s11897-011-0062-8
https://doi.org/10.1007/s11897-011-0062-8
Autor:
Frank Lezoualc'h, Eric Morel, Ana María Gómez, Bertrand Crozatier, Magali Berthouze, Mélanie Métrich
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 459:535-546
Exchange proteins directly activated by cyclic AMP (Epac) were discovered 10 years ago as new sensors for the second messenger cyclic AMP (cAMP). Epac family, including Epac1 and Epac2, are guanine nucleotide exchange factors for the Ras-like small G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcc294ead8a210ca7964958e541f50d
https://doi.org/10.1007/s00424-009-0747-y
https://doi.org/10.1007/s00424-009-0747-y
Autor:
Keith D. Wilkinson, Robert J. Lefkowitz, Arun K. Shukla, Kunhong Xiao, Seungkirl Ahn, Sudha K. Shenoy, Aalok S. Modi, William E. Miller, Magali Berthouze
Publikováno v:
Proceedings of the National Academy of Sciences. 106:6650-6655
β-Arrestins are multifunctional adaptors that mediate the desensitization, internalization, and some signaling functions of seven-transmembrane receptors (7TMRs). Agonist-stimulated ubiquitination of β-arrestin2 mediated by the E3 ubiquitin ligase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20033b9979d0caf7a2bfa289b652a3f
https://doi.org/10.1073/pnas.0901083106
https://doi.org/10.1073/pnas.0901083106
Autor:
Frank Lezoualc'h, Céline Rivière, Jean-Louis Soulier, Jean-Pierre Monti, Olivier Russo, Sames Sicsic, Marthe Cachard-Chastel, Isabelle Berque-Bestel, Tristan Richard, Mireille Giner, Magali Berthouze
Publikováno v:
Journal of Medicinal Chemistry. 52:2214-2225
Serotonin 5-HT(4) receptor (5-HT(4)R) agonists are of particular interest for the treatment of Alzheimer's disease because of their ability to ameliorate cognitive deficits and to modulate production of amyloid beta-protein (Abeta). However, despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f92df50bc84ffa6d24be4d7e4425ed
https://doi.org/10.1021/jm801327q
https://doi.org/10.1021/jm801327q
Autor:
Magali Berthouze, Eric Morel, Ana-Maria Gomez, Philippe Charron, Mélanie Métrich, Frank Lezoualc'h, Laetitia Pereira
Publikováno v:
Pharmacological Reports. 61:146-153
The cyclic AMP (cAMP)-binding proteins, Epac, are guanine nucleotide exchange factors for the Ras-like small GTPases. Since their discovery in 1998 and with the development of specific Epac agonists, many data in the literature have illustrated their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f2c7df02ffe59b41267f4db3fad798
https://doi.org/10.1016/s1734-1140(09)70017-9
https://doi.org/10.1016/s1734-1140(09)70017-9
Autor:
Johan Hoebeke, Simone Garcia, Jean-Christophe Peter, Magali Berthouze, Frank Lezoualc'h, Rehab Kamel, Pierre Eftekhari, Isabelle Berque-Bestel
Publikováno v:
Biochemical Pharmacology. 70:1009-1018
Splenocytes from a BALB/c mouse immunised with a synthetic peptide corresponding to the second extracellular loop of the 5-HT4 receptor were fused with SP2/O myeloma cells to produce a monoclonal antibody. The monoclonal antibody was of the IgG2b iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbf4a82fca2d87e71b589f9b3edd456
https://doi.org/10.1016/j.bcp.2005.07.005
https://doi.org/10.1016/j.bcp.2005.07.005
Autor:
Lucie Rivail, Bernard Maigret, Mireille Giner, Monique Gastineau, Isabelle Berque-Bestel, Frank Lezoualc'h, Sames Sicsic, Magali Berthouze, Rodolphe Fischmeister, Jean-Louis Soulier
Publikováno v:
British Journal of Pharmacology. 143:361-370
A body of evidences suggests that a hydrophobic pocket of the human 5-HT4 receptor contributes to the high affinity of some bulky 5-HT4 ligands. A thorough study of this pocket was performed using mutagenesis and molecular modeling. Ligand binding or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9db6caed5b198b1ab0daf29235e59f0a
https://doi.org/10.1038/sj.bjp.0705950
https://doi.org/10.1038/sj.bjp.0705950
Autor:
Claudine Deloménie, Anne-Coline Laurent, Maxime Branchereau, Frank Lezoualc'h, Olivier Cazorla, Loubina Fazal, Alexandre Lucas, Pauline Soulas-Sprauel, Florence Tortosa, Magali Breckler, Pauline Marck, Christophe Heymes, Eric Morel, Magali Berthouze-Duquesnes, Bertrand Crozatier, Audrey Varin, Jean-Nicolas Schickel, Malik Bisserier, Annélie de Régibus
Publikováno v:
Circulation. 131(4)
Background— Cardiac hypertrophy is an early hallmark during the clinical course of heart failure and is regulated by various signaling pathways. However, the molecular mechanisms that negatively regulate these signal transduction pathways remain po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f56567a62dcb2278d6cfeec469659b
https://pubmed.ncbi.nlm.nih.gov/25369805
https://pubmed.ncbi.nlm.nih.gov/25369805
Publikováno v:
Biochemical Society Transactions
Biochemical Society Transactions, Portland Press, 2012, 40 (1), pp.51-7. ⟨10.1042/BST20110642⟩
Biochemical Society Transactions, 2012, 40 (1), pp.51-7. ⟨10.1042/BST20110642⟩
Biochemical Society Transactions, Portland Press, 2012, 40 (1), pp.51-7. ⟨10.1042/BST20110642⟩
Biochemical Society Transactions, 2012, 40 (1), pp.51-7. ⟨10.1042/BST20110642⟩
International audience; Epacs (exchange proteins directly activated by cAMP) are guanine-nucleotide-exchange factors for the Ras-like small GTPases Rap1 and Rap2. Epacs were discovered in 1998 as new sensors for the second messenger cAMP acting in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43e4510fcd467cadf40204d4af058db
https://www.hal.inserm.fr/inserm-01009688
https://www.hal.inserm.fr/inserm-01009688
