Gut-first Parkinson's disease is encoded by gut dysbiome.

Autor: Munoz-Pinto MF; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.; Present affiliation: Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Seville, Seville, Spain., Candeias E; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal., Melo-Marques I; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.; PhD Programme in Experimental Biology and Biomedicine (PDBEB), Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal., Esteves AR; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal., Maranha A; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal., Magalhães JD; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.; PhD Programme in Experimental Biology and Biomedicine (PDBEB), Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal., Carneiro DR; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Department of Neurology, CHUC - Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, Coimbra, Portugal., Sant'Anna M; Department of Gastroenterogy, CHUC - Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal., Pereira-Santos AR; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.; PhD Programme in Experimental Biology and Biomedicine (PDBEB), Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal., Abreu AE; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal., Nunes-Costa D; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal., Alarico S; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal., Tiago I; Centre for Functional Ecology, University of Coimbra, Coimbra, Portugal., Morgadinho A; Department of Neurology, CHUC - Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal., Lemos J; Department of Neurology, CHUC - Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, Coimbra, Portugal., Figueiredo PN; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Department of Gastroenterogy, CHUC - Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal., Januário C; Department of Neurology, CHUC - Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, Coimbra, Portugal., Empadinhas N; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. numenius@cnc.uc.pt.; Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal. numenius@cnc.uc.pt., Cardoso SM; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. sicardoso@fmed.uc.pt.; Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal. sicardoso@fmed.uc.pt.; Faculty of Medicine, University of Coimbra, Coimbra, Portugal. sicardoso@fmed.uc.pt.

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2024 Oct 24; Vol. 19 (1), pp. 78. Date of Electronic Publication: 2024 Oct 24.

Nocardia cyriacigeorgica Elicits Gut Disturbances in a Leaky Gut Model of Colitis, but Not the Harmful Cascade Leading to Gut-First Parkinson's Disease.

Autor: Magalhães JD; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal.; Ph.D. Programme in Biomedicine and Experimental Biology (PDBEB), Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal., Candeias E; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal., Melo-Marques I; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal., Abreu AE; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal., Pereira-Santos AR; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal.; Ph.D. Programme in Biomedicine and Experimental Biology (PDBEB), Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal., Esteves AR; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal., Cardoso SM; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal., Empadinhas N; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 18; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 18.

Mitochondrial signaling on innate immunity activation in Parkinson disease.

Autor: Magalhães JD; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Programme in Biomedicine and Experimental Biology (PDBEB), Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal., Cardoso SM; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Institute of Cellular and Molecular Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. Electronic address: sicardoso@fmed.uc.pt.

Publikováno v: Current opinion in neurobiology [Curr Opin Neurobiol] 2023 Feb; Vol. 78, pp. 102664. Date of Electronic Publication: 2022 Dec 17.

Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine.

Autor: Canedo T; Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; Faculdade de Medicina da Universidade do Porto (FMUP), Porto, Portugal., Portugal CC; Glial Cell Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal. camila.portugal@ibmc.up.pt., Socodato R; Glial Cell Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal., Almeida TO; Glial Cell Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal., Terceiro AF; Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal., Bravo J; Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal., Silva AI; Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal., Magalhães JD; Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal., Guerra-Gomes S; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal., Oliveira JF; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.; IPCA-EST-2Ai, Polytechnic Institute of Cávado and Ave, Applied Artificial Intelligence, Barcelos, Portugal., Sousa N; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Magalhães A; Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal., Relvas JB; Faculdade de Medicina da Universidade do Porto (FMUP), Porto, Portugal.; Glial Cell Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal., Summavielle T; Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal. tsummavi@ibmc.up.pt.; ESS.PP, Escola Superior de Saúde do Politécnico do Porto, Porto, Portugal. tsummavi@ibmc.up.pt.

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2021 Dec; Vol. 46 (13), pp. 2358-2370. Date of Electronic Publication: 2021 Aug 16.

Novel Donepezil-Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer's Disease.

Autor: Queda F; Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal., Calò S; Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'Aldo Moro', Via E. Orabona 4, I-70125 Bari, Italy., Gwizdala K; Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal., Magalhães JD; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal., Cardoso SM; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.; Institute of Molecular and Cell Biology, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal., Chaves S; Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal., Piemontese L; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'Aldo Moro', Via E. Orabona 4, I-70125 Bari, Italy.; National Research Council (CNR)-ISPA, via Amendola 122/O, 70126 Bari, Italy., Santos MA; Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2021 Mar 16; Vol. 26 (6). Date of Electronic Publication: 2021 Mar 16.