Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy.

Autor: Maliah A; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Santana-Magal N; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Parikh S; The Ragon Institute of Mass General, MIT and Harvard 600/625 Main Street, Cambridge, MA, USA., Gordon S; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Reshef K; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Sade Y; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Khateeb A; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Richter A; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Gutwillig A; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Parikh R; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Golan T; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Krissi M; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Na M; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Binshtok G; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Manich P; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Elkoshi N; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Grisaru-Tal S; Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Zemser-Werner V; Institute of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Brenner R; Institute of Oncology, E. Wolfson Medical Center, Holon, Israel., Vaknine H; Institute of Pathology, E. Wolfson Medical Center, Holon, Israel., Nizri E; Peritoneal Surface Malignancies and Melanoma Unit, Department of Surgery A, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel., Moyal L; Felsenstein Medical Research Center, Tel-Aviv University and the Division of Dermatology, Rabin Medical Center, Petach Tikva, Israel., Amitay-Laish I; Felsenstein Medical Research Center, Tel-Aviv University and the Division of Dermatology, Rabin Medical Center, Petach Tikva, Israel., Rosemberg L; School of Zoology, Tel Aviv University, Tel Aviv-Yafo, Israel., Munitz A; Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Kronfeld-Schor N; School of Zoology, Tel Aviv University, Tel Aviv-Yafo, Israel., Shifrut E; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Faculty of Life Sciences, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv, Israel.; Dotan Center for Advanced Therapies, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Kobiler O; Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Madi A; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Geiger T; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Carmi Y; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. yaroncarmi@tauex.tau.ac.il., Levy C; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. carmitlevy@tauex.tau.ac.il.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 27; Vol. 15 (1), pp. 8354. Date of Electronic Publication: 2024 Sep 27.

Graph analysis uncovers an opposing impact of methylphenidate on connectivity patterns within default mode network sub-divisions.

Autor: Daood M; School of Psychological Sciences, University of Haifa, 199 Aba Khoushy Ave. Mount Carmel, Haifa, 31905, Israel.; Sakhnin College of Education, Sakhnin, Israel., Magal N; School of Psychological Sciences, University of Haifa, 199 Aba Khoushy Ave. Mount Carmel, Haifa, 31905, Israel., Peled-Avron L; The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel.; Department of Psychology, Bar-Ilan University, Ramat-Gan, Israel., Nevat M; School of Psychological Sciences, University of Haifa, 199 Aba Khoushy Ave. Mount Carmel, Haifa, 31905, Israel., Ben-Hayun R; Stroke and Cognition Institute, Rambam Health Care Campus, Haifa, Israel.; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Aharon-Peretz J; Stroke and Cognition Institute, Rambam Health Care Campus, Haifa, Israel.; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Tomer R; School of Psychological Sciences, University of Haifa, 199 Aba Khoushy Ave. Mount Carmel, Haifa, 31905, Israel.; The Integrated Brain and Behavior Research Center (IBBRC), University of Haifa, Haifa, Israel., Admon R; School of Psychological Sciences, University of Haifa, 199 Aba Khoushy Ave. Mount Carmel, Haifa, 31905, Israel. radmon@psy.haifa.ac.il.; The Integrated Brain and Behavior Research Center (IBBRC), University of Haifa, Haifa, Israel. radmon@psy.haifa.ac.il.

Publikováno v: Behavioral and brain functions : BBF [Behav Brain Funct] 2024 Jun 20; Vol. 20 (1), pp. 15. Date of Electronic Publication: 2024 Jun 20.

The Diagnostic Yield and Implications of Targeted Founder Pathogenic Variant Testing in an Israeli Cohort.

Autor: Abu Shtaya A; Recanati Genetics Institute, Rabin Medical Center-Beilinson Hospital, Petach Tikva 4941492, Israel.; Unit of Gastroenterology, Lady Davis Carmel Medical Center, Haifa 3436212, Israel., Kedar I; Recanati Genetics Institute, Rabin Medical Center-Beilinson Hospital, Petach Tikva 4941492, Israel., Mattar S; Department of Surgery B, Carmel Medical Center, Haifa 3436212, Israel., Mahamid A; Department of Surgery B, Carmel Medical Center, Haifa 3436212, Israel., Basel-Salmon L; Recanati Genetics Institute, Rabin Medical Center-Beilinson Hospital, Petach Tikva 4941492, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Felsenstein Medical Research Center, Petach Tikva 4920235, Israel.; Pediatric Genetics Unit, Schneider Children's Medical Center of Israel, Petch Tikva 49202, Israel., Farage Barhom S; Recanati Genetics Institute, Rabin Medical Center-Beilinson Hospital, Petach Tikva 4941492, Israel., Naftaly Nathan S; Recanati Genetics Institute, Rabin Medical Center-Beilinson Hospital, Petach Tikva 4941492, Israel., Magal N; Recanati Genetics Institute, Rabin Medical Center-Beilinson Hospital, Petach Tikva 4941492, Israel., Azulay N; Recanati Genetics Institute, Rabin Medical Center-Beilinson Hospital, Petach Tikva 4941492, Israel., Levy Zalcberg M; Genetics Institute, Soroka Medical Center, Beer Sheva 84101, Israel., Chen-Shtoyerman R; Adelson School of Medicine, Department of Molecular Biology, Ariel University, Ariel 40700, Israel.; Kaplan Medical Center, Genetics Institute, Oncogenetic Clinic, Rehovot 7610001, Israel., Segol O; Unit of Gastroenterology, Lady Davis Carmel Medical Center, Haifa 3436212, Israel., Seri M; Recanati Genetics Institute, Rabin Medical Center-Beilinson Hospital, Petach Tikva 4941492, Israel., Reznick Levi G; Genetics Institute, Rambam Health Care Campus, Haifa 31096, Israel., Shkedi-Rafid S; Department of Genetics and Metabolic Diseases, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel., Vinkler C; Institute for Medical Genetics, Wolfson Medical Center, Holon 5822012, Israel., Netzer I; Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel., Hagari Bechar O; Recanati Genetics Institute, Rabin Medical Center-Beilinson Hospital, Petach Tikva 4941492, Israel., Chamma L; Recanati Genetics Institute, Rabin Medical Center-Beilinson Hospital, Petach Tikva 4941492, Israel., Liberman S; Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem 9112102, Israel., Goldberg Y; Recanati Genetics Institute, Rabin Medical Center-Beilinson Hospital, Petach Tikva 4941492, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

Publikováno v: Cancers [Cancers (Basel)] 2023 Dec 24; Vol. 16 (1). Date of Electronic Publication: 2023 Dec 24.

Bi-allelic variants in INTS11 are associated with a complex neurological disorder.

Autor: Tepe B; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA., Macke EL; Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA., Niceta M; Molecular Genetics and Functional Genomics, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Weisz Hubshman M; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Kanca O; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA., Schultz-Rogers L; Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA., Zarate YA; Division of Genetics and Metabolism, University of Kentucky, Lexington, KY, USA., Schaefer GB; Section of Genetics and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Granadillo De Luque JL; Division of Genetics and Genomic Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA., Wegner DJ; Edward Mallinckrodt Department of Pediatrics, Washington University in St. Louis School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri, USA., Cogne B; Laboratory of Molecular Genetics, CHU de Nantes, Nantes, France., Gilbert-Dussardier B; Department of Medical Genetics, CHU de Poitiers, Poitiers, France., Le Guillou X; Department of Medical Genetics, CHU de Poitiers, Poitiers, France., Wagner EJ; Department of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester School of Medicine, Rochester, NY 14642, USA., Pais LS; Division of Genetics and Genomics, and Howard Hughes Medical Institute, Boston Children's Hospital, and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Neil JE; Division of Genetics and Genomics, and Howard Hughes Medical Institute, Boston Children's Hospital, and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA, USA., Mochida GH; Division of Genetics and Genomics, and Howard Hughes Medical Institute, Boston Children's Hospital, and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA., Walsh CA; Division of Genetics and Genomics, and Howard Hughes Medical Institute, Boston Children's Hospital, and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA, USA., Magal N; The Raphael Recanati Genetic Institute, Rabin Medical Center, Petach Tikva, Israel., Drasinover V; The Raphael Recanati Genetic Institute, Rabin Medical Center, Petach Tikva, Israel., Shohat M; Cancer Research Center, Chaim Sheba Medical Center, Ramat Gan, Israel; Medical Genetics Institute of Maccabi HMO, Rechovot, Israel., Schwab T; Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA., Schmitz C; Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA., Clark K; Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA., Fine A; Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA., Lanpher B; Department of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA., Gavrilova R; Department of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA., Blanc P; APHP, Département de génétique, Sorbonne Université, GRC n°19, ConCer-LD, Centre de Référence déficiences intellectuelles de causes rares, Hôpital Armand Trousseau, 75012 Paris, France., Burglen L; APHP, Département de génétique, Sorbonne Université, GRC n°19, ConCer-LD, Centre de Référence déficiences intellectuelles de causes rares, Hôpital Armand Trousseau, 75012 Paris, France., Afenjar A; APHP. SU, Centre de Référence Malformations et maladies congénitales du cervelet, département de génétique et embryologie médicale, Hôpital Trousseau, 75012 Paris, France., Steel D; Developmental Neurosciences, Zayed Centre for Research into Rare Disease in Children, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Neurology, Great Ormond Street Hospital for Children, London, UK., Kurian MA; Developmental Neurosciences, Zayed Centre for Research into Rare Disease in Children, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Neurology, Great Ormond Street Hospital for Children, London, UK., Prabhakar P; Department of Neurology, Great Ormond Street Hospital for Children, London, UK., Gößwein S; Institute for Clinical Genetics, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany., Di Donato N; Institute for Clinical Genetics, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany., Bertini ES; Unit of Neuromuscular and Neurodegenerative Disorders, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Wangler MF; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA., Yamamoto S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA., Tartaglia M; Molecular Genetics and Functional Genomics, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Klee EW; Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA; Department of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA., Bellen HJ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: hbellen@bcm.edu.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2023 May 04; Vol. 110 (5), pp. 774-789. Date of Electronic Publication: 2023 Apr 12.

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