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1774P Immunological-molecular profiling of chondrosarcoma (ChS)

Autor: Rutkowski, P., Zając, A.E., Szumera-Cieckiewicz, A., Piatkowski, J., Teterycz, P., Palmerini, E., Dutour, A., Tuziak, J., Wagrodzki, M., Tysarowski, A., Gambarotti, M., Frega, G., Pierini, M., Righi, A., Magagnoli, G., Jean-Denis, M., Ibrahim, T., Blay, J-Y., Golik, P., Czarnecka, A.M.

Publikováno v: In Annals of Oncology September 2024 35 Supplement 2:S1056-S1056

Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma

Autor: García-Domínguez DJ, Hajji N, Sánchez-Molina S, Figuerola-Bou E, de Pablos RM, Espinosa-Oliva AM, Andrés-León E, Terrón-Camero LC, Flores-Campos R, Pascual-Pastó G, Robles MJ, Machado I, Llombart-Bosch A, Magagnoli G, Scotlandi K, Carcaboso AM, Mora J, de Álava E, Hontecillas-Prieto L

Publikováno v: Oncogene
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname

Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver is a fusion gene, EWSR1-FLI1. Although the essential role of EWSR1-FLI1 protein in the regulation of oncogenesis, survival, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::3ef43eb4c98383b3681da7ed7f9b5fb8
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19977

Osteogenic sarcomas of the hands: A case series with emphasis in its peculiarities and literature review.

Autor: de la Guardia V; Department of Pathology, Complejo Hospitalario Metropolitano CSS, Panama, Panama., O'Meally AA; Department of Orthopaedic Surgery, Complejo Hospitalario Metropolitano CSS, Panama, Panama., Gambarotti M; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Spinnato P; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Frisoni T; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Cocchi S; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Magagnoli G; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Ibrahim T; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Benini S; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Pacheco M; Department of Pathology, Complejo Hospitalario Metropolitano CSS, Panama, Panama., Righi A; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. Electronic address: alberto.righi@ior.it.

Publikováno v: Pathology, research and practice [Pathol Res Pract] 2023 Feb; Vol. 242, pp. 154326. Date of Electronic Publication: 2023 Jan 20.

ABCA6 affects the malignancy of Ewing sarcoma cells via cholesterol-guided inhibition of the IGF1R/AKT/MDM2 axis.

Autor: Pasello M; Experimental Oncology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, 40136, Italy. michela.pasello@ior.it., Giudice AM; Experimental Oncology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, 40136, Italy.; Alma Mater Institute On Healthy Planet - Alma Healthy Planet, University of Bologna, Bologna, Italy.; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy., Cristalli C; Experimental Oncology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, 40136, Italy., Manara MC; Experimental Oncology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, 40136, Italy., Mancarella C; Experimental Oncology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, 40136, Italy., Parra A; Experimental Oncology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, 40136, Italy., Serra M; Experimental Oncology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, 40136, Italy., Magagnoli G; Department of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Cidre-Aranaz F; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany., Grünewald TGP; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Bini C; Laboratory of Forensic Genetics, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Lollini PL; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy., Longhi A; Osteoncologia, Sarcomi dell'osso e dei Tessuti Molli e Terapie Innovative, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Donati DM; Unit of 3rd Orthopaedic and Traumatologic Clinic Prevalently Oncologic, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.; Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy., Scotlandi K; Experimental Oncology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, 40136, Italy. katia.scotlandi@ior.it.

Publikováno v: Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2022 Dec; Vol. 45 (6), pp. 1237-1251. Date of Electronic Publication: 2022 Sep 23.