Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Maga Rowicka"'
Autor:
Bernard Fongang, Yannick N. Wadop, Yingjie Zhu, Eric J. Wagner, Andrzej Kudlicki, Maga Rowicka
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 5686-5697 (2023)
Finding the 3D structure of large, multi-subunit complexes is difficult, despite recent advances in cryo-EM technology, due to remaining challenges to expressing and purifying subunits. Computational approaches that predict protein-protein interactio
Externí odkaz:
https://doaj.org/article/c00fe776b1db45a6953ea60affc4756c
Autor:
Alexy Promonet, Ismaël Padioleau, Yaqun Liu, Lionel Sanz, Anna Biernacka, Anne-Lyne Schmitz, Magdalena Skrzypczak, Amélie Sarrazin, Clément Mettling, Maga Rowicka, Krzysztof Ginalski, Frédéric Chedin, Chun-Long Chen, Yea-Lih Lin, Philippe Pasero
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
While R-loops can alter cell homeostasis, it is unclear what determines their toxicity. Here, the authors, by using Top1 knockdown as a tool to enhance the formation of R-loops at certain genomic sites, reveal and characterize a proportion of R-loops
Externí odkaz:
https://doaj.org/article/bd1932962b864455ac3b032015f1a0ac
Autor:
Yingjie Zhu, Anna Biernacka, Benjamin Pardo, Norbert Dojer, Romain Forey, Magdalena Skrzypczak, Bernard Fongang, Jules Nde, Razie Yousefi, Philippe Pasero, Krzysztof Ginalski, Maga Rowicka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Measuring relative frequencies of DNA double-strand breaks between loci does not provide the full physiological relevance of those breaks. Here Rowicka and colleagues present qDSB-Seq method which uses spike-in double-strand breaks induced by a restr
Externí odkaz:
https://doaj.org/article/1da150c75932433b96bb662db60a6ecc
Autor:
Razie Yousefi, Maga Rowicka
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 12, p e1007519 (2019)
Eukaryotic DNA replication is elaborately orchestrated to duplicate the genome timely and faithfully. Replication initiates at multiple origins from which replication forks emanate and travel bi-directionally. The complex spatio-temporal regulation o
Externí odkaz:
https://doaj.org/article/683c56095e1e41c3b1ce716b8a9fd262
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0120520 (2015)
Sequencing microRNA, reduced representation sequencing, Hi-C technology and any method requiring the use of in-house barcodes result in sequencing libraries with low initial sequence diversity. Sequencing such data on the Illumina platform typically
Externí odkaz:
https://doaj.org/article/3ef32fd8f8af441ead40ac1953804832
Autor:
Teresa Szczepińska, Jan Kutner, Michał Kopczyński, Krzysztof Pawłowski, Andrzej Dziembowski, Andrzej Kudlicki, Krzysztof Ginalski, Maga Rowicka
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 3, p e1003514 (2014)
We present a general probabilistic framework for predicting the substrate specificity of enzymes. We designed this approach to be easily applicable to different organisms and enzymes. Therefore, our predictive models do not rely on species-specific p
Externí odkaz:
https://doaj.org/article/ea542f2c61514b8b97d558b23c4cb478
Autor:
Tomasz Wlodarski, Jan Kutner, Joanna Towpik, Lukasz Knizewski, Leszek Rychlewski, Andrzej Kudlicki, Maga Rowicka, Andrzej Dziembowski, Krzysztof Ginalski
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23168 (2011)
Methylation is one of the most common chemical modifications of biologically active molecules and it occurs in all life forms. Its functional role is very diverse and involves many essential cellular processes, such as signal transduction, transcript
Externí odkaz:
https://doaj.org/article/c05fd22c0ce54cf597fe793b0ffb6cc2
Autor:
Mary-Lee Dequéant, Sebastian Ahnert, Herbert Edelsbrunner, Thomas M A Fink, Earl F Glynn, Gaye Hattem, Andrzej Kudlicki, Yuriy Mileyko, Jason Morton, Arcady R Mushegian, Lior Pachter, Maga Rowicka, Anne Shiu, Bernd Sturmfels, Olivier Pourquié
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2856 (2008)
While genome-wide gene expression data are generated at an increasing rate, the repertoire of approaches for pattern discovery in these data is still limited. Identifying subtle patterns of interest in large amounts of data (tens of thousands of prof
Externí odkaz:
https://doaj.org/article/8445e663f8054e0a9b81a048ca826293
Autor:
Krzysztof Ginalski, Maga Rowicka, Magdalena Skrzypczak, Anna Biernacka, Philippe Pasero, Yingjie Zhu
Publikováno v:
Nat Protoc
DNA double-strand breaks (DSBs) are implicated in various physiological processes, such as class-switch recombination or crossing-over during meiosis, but also present a threat to genome stability. Extensive evidence shows that DSBs are a primary sou
Autor:
Razie Yousefi, Maga Rowicka, Benjamin Pardo, Norbert Dojer, Yingjie Zhu, Philippe Pasero, Krzysztof Ginalski, Anna Biernacka, Jules Nde, Bernard Fongang, Romain Forey, Magdalena Skrzypczak
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-10332-8⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-10332-8⟩
DNA double-strand breaks (DSBs) are among the most lethal types of DNA damage and frequently cause genome instability. Sequencing-based methods for mapping DSBs have been developed but they allow measurement only of relative frequencies of DSBs betwe