Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Mafalda Lopes‐da‐Silva"'
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Akademický článek
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage
Autor: Rita Rosado-Ramos, Gonçalo M. Poças, Daniela Marques, Alexandre Foito, David M. Sevillano, Mafalda Lopes-da-Silva, Luís G. Gonçalves, Regina Menezes, Marcel Ottens, Derek Stewart, Alain Ibáñez de Opakua, Markus Zweckstetter, Miguel C. Seabra, César S. Mendes, Tiago Fleming Outeiro, Pedro M. Domingos, Cláudia N. Santos
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
In this work, the authors identify Genipin as a small iridoid able to prevent alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
Externí odkaz: https://doaj.org/article/6e0052eb0e2b432c9b02cba0d241c7e9
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2
Akademický článek
Structure modeling hints at a granular organization of the Golgi ribbon
Autor: Karen M. Page, Jessica J. McCormack, Mafalda Lopes-da-Silva, Francesca Patella, Kimberly Harrison-Lavoie, Jemima J. Burden, Ying-Yi Bernadette Quah, Dominic Scaglioni, Francesco Ferraro, Daniel F. Cutler
Publikováno v: BMC Biology, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background In vertebrate cells, the Golgi functional subunits, mini-stacks, are linked into a tri-dimensional network. How this “ribbon” architecture relates to Golgi functions remains unclear. Are all connections between mini-stacks equ
Externí odkaz: https://doaj.org/article/ea370c24b3234d728be9cf0d1e4f597f
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3
Akademický článek
Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes
Autor: Ana F. Raimundo, Sofia Ferreira, Vânia Pobre, Mafalda Lopes-da-Silva, José A. Brito, Daniel J. V. A. dos Santos, Nuno Saraiva, Cláudia N. dos Santos, Regina Menezes
Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)
IntroductionDiabetes is one of the major metabolic diseases worldwide. Despite being a complex systemic pathology, the aggregation and deposition of Islet Amyloid Polypeptide (IAPP), or amylin, is a recognized histopathological marker of the disease.
Externí odkaz: https://doaj.org/article/a547e5291eb2421b9237abf1524f1d42
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4
Akademický článek
Delay of EGF-Stimulated EGFR Degradation in Myotonic Dystrophy Type 1 (DM1)
Autor: Eva Alegre-Cortés, Alberto Giménez-Bejarano, Elisabet Uribe-Carretero, Marta Paredes-Barquero, André R. A. Marques, Mafalda Lopes-da-Silva, Otília V. Vieira, Saray Canales-Cortés, Pedro J. Camello, Guadalupe Martínez-Chacón, Ana Aiastui, Roberto Fernández-Torrón, Adolfo López de Munain, Patricia Gomez-Suaga, Mireia Niso-Santano, Rosa A. González-Polo, José M. Fuentes, Sokhna M. S. Yakhine-Diop
Publikováno v: Cells, Vol 11, Iss 19, p 3018 (2022)
Myotonic dystrophy type 1 (DM1) is an autosomal dominant disease caused by a CTG repeat expansion in the 3′ untranslated region of the dystrophia myotonica protein kinase gene. AKT dephosphorylation and autophagy are associated with DM1. Autophagy
Externí odkaz: https://doaj.org/article/63ec18c48d0044c082b29aaa2f385fd7
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5
Deacidification of endolysosomes by neuronal aging drives synapse loss
Autor: Tatiana Burrinha, César Cunha, Michael J. Hall, Mafalda Lopes‐da‐Silva, Miguel C. Seabra, Cláudia Guimas Almeida
Funding Information: The authors thank the lab members for technical assistance, helpful discussions and for the critical reading of the manuscript. The authors thank Dr. S. Miserey‐Lenkei (Institute Curie), Dr. D. Barral, Dr. O. Vieira and Dr. S.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daab2b7d4309106adc318333cf107156
https://hdl.handle.net/10362/155155
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6
Structure modeling hints at a granular organization of the Golgi ribbon
Autor: Karen M. Page, Jessica J. McCormack, Mafalda Lopes-da-Silva, Francesca Patella, Kimberly Harrison-Lavoie, Jemima J. Burden, Ying-Yi Bernadette Quah, Dominic Scaglioni, Francesco Ferraro, Daniel F. Cutler
Publikováno v: BMC biology. 20(1)
Background In vertebrate cells, the Golgi functional subunits, mini-stacks, are linked into a tri-dimensional network. How this “ribbon” architecture relates to Golgi functions remains unclear. Are all connections between mini-stacks equal? Is th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0345caca9befe8a1ce8f4bcc2e3ca7f
https://pubmed.ncbi.nlm.nih.gov/35549945
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7
Structure modeling hints at a granular organization of the Vertebrate Golgi ribbon
Autor: Kimberley Harrison-Lavoie, Daniel F. Cutler, Jessica McCormack, Ying-Yi Bernadette Quah, Francesca Patella, Francesco Ferraro, Jemima J. Burden, Karen M. Page, Mafalda Lopes-da-Silva, Dominic Scaglioni
Vertebrate cells display a specific Golgi apparatus architecture, known as the “ribbon”, where the functional subunits, the mini-stacks, are linked into a tridimensional network. The importance of the ribbon architecture is underscored by evidenc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a81c1132dbdd1f89e4c77364556687e1
https://doi.org/10.1101/2021.08.30.458089
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8
Formation of lipofuscin-like autofluorescent granules in the retinal pigment epithelium requires lysosome dysfunction
Autor: Clare E. Futter, Ana S. Falcao, Cristina Escrevente, Miguel M. Mesquita, Paul Nicklin, Ana C. Fradinho, Sandra Tenreiro, Pedro Antas, Mafalda Lopes-da-Silva, Thomas Ciossek, Michael J. Hall, Ines S. Ferreira, Daniela Oliveira, M. Helena Cardoso, Miguel C. Seabra
Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Investigative Ophthalmology & Visual Science
Funding Information: Supported by Funda??o para a Ciência e Tecnologia (FCT) ? Portugal co-funded by FEDER under the PT2020 Partnership Agreement (to MCS, including project PTDC/MED-PAT/30385/2017, iNOVA4Health-UIDB/04462/2020, research infrastructu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e27c694cb824b11689ba198596642a
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10
Weibel−Palade bodies at a glance
Autor: Daniel F. Cutler, Francesca Patella, Francesco Ferraro, Jessica McCormack, Mafalda Lopes da Silva
Publikováno v: Journal of Cell Science. 130:3611-3617
The vascular environment can rapidly alter, and the speed with which responses to both physiological and pathological changes are required necessitates the existence of a highly responsive system. The endothelium can quickly deliver bioactive molecul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25987f559244c0e333c0c2a19c56657
https://doi.org/10.1242/jcs.208033
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