Combination of cytokine responses indicative of latent TB and active TB in Malawian adults.

Autor: Yun-Gyoung Hur, Patricia Gorak-Stolinska, Anne Ben-Smith, Maeve K Lalor, Steven Chaguluka, Russell Dacombe, T Mark Doherty, Tom H Ottenhoff, Hazel M Dockrell, Amelia C Crampin

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79742 (2013)

An IFN-γ response to M. tuberculosis-specific antigens is an effective biomarker for M. tuberculosis infection but it cannot discriminate between latent TB infection and active TB disease. Combining a number of cytokine/chemokine responses to M. tub

Externí odkaz: https://doaj.org/article/e53d802a4ee04177ae61b6f92bdd9779

Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa.

Autor: Jayne S Sutherland, Maeve K Lalor, Gillian F Black, Lyn R Ambrose, Andre G Loxton, Novel N Chegou, Desta Kassa, Adane Mihret, Rawleigh Howe, Harriet Mayanja-Kizza, Marie P Gomez, Simon Donkor, Kees Franken, Willem Hanekom, Michel R Klein, Shreemanta K Parida, W Henry Boom, Bonnie A Thiel, Amelia C Crampin, Martin Ota, Gerhard Walzl, Tom H M Ottenhoff, Hazel M Dockrell, Stefan H E Kaufmann, GCGH Biomarkers for TB consortium

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74080 (2013)

BACKGROUND:Tuberculosis (TB) remains a global health threat with 9 million new cases and 1.4 million deaths per year. In order to develop a protective vaccine, we need to define the antigens expressed by Mycobacterium tuberculosis (Mtb), which are re

Externí odkaz: https://doaj.org/article/123f1077ef0d46748fd6f8db23b29b37

Trends and risk factors for death and excess all-cause mortality among notified tuberculosis patients in the UK: an analysis of surveillance data

Autor: Debora Pedrazzoli, Katharina Kranzer, H. Lucy Thomas, Maeve K. Lalor

Publikováno v: ERJ Open Research, Vol 5, Iss 4 (2019)

Introduction In the UK, several hundred patients notified with tuberculosis (TB) die every year. The aim of this article is to describe trends in deaths among notified TB patients, explore risk factors associated with death and compare all-cause mort

Externí odkaz: https://doaj.org/article/e21dca1e49fc4f7ba02ba1cc60c47885

The impact of HIV infection on tuberculosis transmission in a country with low tuberculosis incidence: a national retrospective study using molecular epidemiology

Autor: Ibrahim Abubakar, Maeve K. Lalor, Helen R. Stagg, Joanne R. Winter, Jennifer Davidson, Colette J Smith, Valerie Delpech

Publikováno v: BMC Medicine, Vol 18, Iss 1, Pp 1-15 (2020)
BMC Medicine
Winter, JR, Smith, CJ, Davidson, JA, Lawlor, MK, Delpech, V, Abubakar, I & Stagg, H R 2020, ' The impact of HIV infection on tuberculosis transmission in a country with low tuberculosis incidence : A national retrospective study using molecular epidemiology ', BMC Medicine, vol. 18, 385 . https://doi.org/10.1186/s12916-020-01849-7

Background HIV is known to increase the likelihood of reactivation of latent tuberculosis to active TB disease; however, its impact on tuberculosis infectiousness and consequent transmission is unclear, particularly in low-incidence settings. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570a96f21cfe575d585f14047c387c9e
https://doaj.org/article/57f67139a9794c46a5a9eb5819375010

Reduction in tuberculosis incidence in the UK from 2011 to 2015: a population-based study

Autor: Maeve K. Lalor, Colin N J Campbell, Dominik Zenner, Sarah R Anderson, Jennifer Davidson, Ross J Harris, Morris C Muzyamba, H Lucy Thomas

Publikováno v: Thorax. 73:769-775

BackgroundFollowing nearly two decades of increasing tuberculosis in the UK, TB incidence decreased by 32% from 2011 to 2015. Explaining this reduction is crucial to informing ongoing TB control efforts.MethodsWe stratified TB cases notified in the U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c2cfafe161e7b3465d81615ff08963f
https://doi.org/10.1136/thoraxjnl-2017-211074