Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Maeve H. Kean"'
Autor:
Nathanyal J. Truax, Fernando Banales Mejia, Megan M. Lafferty, Erin T. Pelkey, Sophia J. Melvin, Maeve H. Kean
Publikováno v:
Synlett. 28:260-264
The electrophilic substitution of indoles with tetronic acid and N-acetyltetramic acid mediated by BF3·OEt2 was investigated. This strategy allowed for the preparation of nine indole-substituted furan-2-ones (indolyl-γ-lactones) and 3-pyrrolin-2-on
Autor:
Deborah O. Kwansare, Maeve H. Kean, Fernando Banales Mejia, Erin T. Pelkey, Megan M. Lafferty, Nathanyal J. Truax
Publikováno v:
The Journal of Organic Chemistry. 81:6808-6815
A simple and flexible approach to 3-pyrrolin-2-one fused carbazoles is disclosed. The key step involves the BF3-mediated electrophilic substitution of indoles with N-alkyl-substituted 3-aryltetramic acids, which provides access to indole-substituted
Autor:
Namita D. Neerukonda, Megan M. Lafferty, Carly E. Rolph, Fernando Banales Mejia, Courtney L. Franceschi, Erin T. Pelkey, Deborah O. Kwansare, Patricia Mowery, Nathanyal J. Truax, Maeve H. Kean
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(2)
Analogs containing a central 3-pyrrolin-2-one core with different methoxyphenyl and/or indole substituents were prepared and tested for anti-proliferative activity in U-937 cells. The most efficacious analogs were non-rigid, (non-fused) contained met