Výsledky vyhledávání - "Maeve Bonner"

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

Autor: Yuan-Ta Lin, Alexander Frank, Li-Huei Tsai, Joel W. Blanchard, Michael Bula, Matheus B. Victor, Hansruedi Mathys, Jose Davila-Velderrain, Lena Zhu, Manolis Kellis, Julia Maeve Bonner, Tak Ko, Leyla Anne Akay, Hugh P. Cam, David A. Bennett

Publikováno v: Nat Med

In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition known as cerebral amyloid angiopathy (CAA), which impairs blood-brain barrier (BBB) function and accelerates cognitive degeneration. Apolipoprotein (APOE4) is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796c6e72f10ca2eb5e7400e54801203f
https://doi.org/10.1038/s41591-020-0886-4

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Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity

Autor: Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Maeve Bonner, Li-Huei Tsai

SummaryApolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing late- onset Alzheimer’s disease and its expression in microglia is associated with pro- inflammatory states. How the interaction of APOE4 microglia with neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e65379af953ea122df84bcbf9fcdeb2
https://doi.org/10.1101/2022.03.21.484146

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Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

Autor: Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, Aine Ni Scannail, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Maeve Bonner, Li-Huei Tsai

Publikováno v: Cell stem cell. 29(8)

Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing sporadic Alzheimer's disease. How the interaction of APOE4 microglia with neurons differs from microglia expressing the disease-neutral APOE3 allele remains unknown. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be0759e8a20915515af99ad4334718d
https://pubmed.ncbi.nlm.nih.gov/35931027

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APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

Autor: Leyla Anne Akay, Susan Lindquist, Agnese Graziosi, Sebastian Boland, William T. Ralvenius, Valeriya Baru, Aleksandra Alicja Arczewska, Nora Kory, Julia Maeve Bonner, Elana Lockshin, Grzegorz Sienski, Caroline A. Lewis, Priyanka Narayan, Blerta Milo, Manolis Kellis, Liang He, David M. Sabatini, Li-Huei Tsai

Publikováno v: Sci Transl Med
PMC

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works The E4 allele of the apolipoprotein E gene (APOE) has been established as a geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4318185a6e20804c536d843839fba1
http://hdl.handle.net/11585/854127

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PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4

Autor: Julia Maeve Bonner, Susan Lindquist, Leyla Anne Akay, M. Inmaculada Barrasa, Julie S. Valastyan, Agnese Graziosi, Valeriya Baru, Aftabul Haque, Yelena Freyzon, Grzegorz Sienski, William R. Hesse, Li-Huei Tsai, Priyanka Narayan, Yuan-Ta Lin, Jinsoo Seo, Blerta Milo, Dirk Landgraf

Publikováno v: Cell Reports, Vol 33, Iss 1, Pp 108224-(2020)
Cell Rep
Elsevier

Summary: The ε4 allele of apolipoprotein E (APOE4) is a genetic risk factor for many diseases, including late-onset Alzheimer’s disease (AD). We investigate the cellular consequences of APOE4 in human iPSC-derived astrocytes, observing an endocyti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33720e98ac0cff7e832c8e35452f808f
http://www.sciencedirect.com/science/article/pii/S2211124720312134

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Diverse structures, functions and uses of FK506 binding proteins

Autor: Julia Maeve Bonner, Gabrielle L. Boulianne

Publikováno v: Cellular Signalling. 38:97-105

FK506 (Tacrolimus), isolated from Streptomyces tsukubaenis is a powerful immunosuppressant shown to inhibit T cell activation. FK506 mediated immunosuppression requires the formation of a complex between FK506, a FK506 binding protein (FKBP) and calc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a70d3e450e27514a40a10efd18f8ac2
https://doi.org/10.1016/j.cellsig.2017.06.013

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A genetic tool to track protein aggregates and control prion inheritance

Autor: Anita L. Manogaran, J. Maeve Bonner, William R. Hesse, Gregory A. Newby, Christopher P. Mancuso, Peter Tsvetkov, Susan Lindquist, Can Kayatekin, Susan W. Liebman, Ahmad S. Khalil, Sohini Chakrabortee, Szilvia Kiriakov, Erinc Hallacli

Summary Protein aggregation is a hallmark of many diseases but also underlies a wide range of positive cellular functions. This phenomenon has been difficult to study because of a lack of quantitative and high-throughput cellular tools. Here, we deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63fa3c71375e272b1e9fb773fc4e36b
https://europepmc.org/articles/PMC5675731/

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Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity

Autor: Priyanka Narayan, Chad L. Myers, Can Kayatekin, Susan Lindquist, Jason Flannick, Saranna Fanning, M. Inmaculada Barrasa, Audra L. Amasino, Giorgio Gaglia, Jose C. Florez, Dirk Landgraf, Julia Maeve Bonner, Charles Boone, Michael Costanzo, William R. Hesse, Justin Nelson, David Pincus

Publikováno v: Cell. 173:62-73.e9

Aggregates of human islet amyloid polypeptide (IAPP) in the pancreas of patients with type-2 diabetes (T2D) are thought to contribute to β-cell dysfunction and death. To understand how IAPP harms cells and how this might be overcome, we created a ye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc051b4925fb8f2b30d93b9df1b00577
https://doi.org/10.1016/j.cell.2018.02.026

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Combined Isothermal Titration and Differential Scanning Calorimetry Define Three-State Thermodynamics of fALS-Associated Mutant Apo SOD1 Dimers and an Increased Population of Folded Monomer

Autor: Kenrick A. Vassall, Ming Sze Tong, Helen R. Broom, Colleen M. Doyle, Elizabeth M. Meiering, Jessica A.O. Rumfeldt, Julia Maeve Bonner

Publikováno v: Biochemistry. 55(3)

Many proteins are naturally homooligomers, homodimers most frequently. The overall stability of oligomeric proteins may be described in terms of the stability of the constituent monomers and the stability of their association; together, these stabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1988bc0aaca7f415ba05b48a1e929c4
https://pubmed.ncbi.nlm.nih.gov/26710831

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