Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Maeva, Dhaynaut"'
Autor:
Yu-Peng Zhou, Moses Q. Wilks, Maeva Dhaynaut, Nicolas J. Guehl, Danielle R. Vesper, Sung-Hyun Moon, Peter A. Rice, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Background 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [11C]3MeO4AP has shown promise due to
Externí odkaz:
https://doaj.org/article/3d734de69661416e837557c698a2e2cb
Autor:
Felicitas J. Detmer, Nathaniel M. Alpert, Sung-Hyun Moon, Maeva Dhaynaut, J. Luis Guerrero, Nicolas J. Guehl, Fangxu Xing, Pedro Brugarolas, Timothy M. Shoup, Marc D. Normandin, Matthieu Pelletier-Galarneau, Georges El Fakhri, Yoann Petibon
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Mitochondrial dysfunction plays a key role in doxorubicin-induced cardiotoxicity (DIC). In this proof-of-principle study, we investigated whether PET mapping of cardiac membrane potential, an indicator of mitochondrial function, could detect
Externí odkaz:
https://doaj.org/article/45f72c7eae84477dbaf9f917eb1916ed
Autor:
Marta Marquié, Cinthya Agüero, Ana C. Amaral, Alberto Villarejo-Galende, Prianca Ramanan, Michael Siao Tick Chong, Nil Sáez-Calveras, Rachel E. Bennett, Eline E. Verwer, Sally Ji Who Kim, Maeva Dhaynaut, Victor E. Alvarez, Keith A. Johnson, Ann C. McKee, Matthew P. Frosch, Teresa Gómez-Isla
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Introduction Chronic traumatic encephalopathy (CTE) is a tauopathy associated to repetitive head trauma. There are no validated in vivo biomarkers of CTE and a definite diagnosis can only be made at autopsy. Recent studies have shown that po
Externí odkaz:
https://doaj.org/article/9039b5f7fb4e47e382c4f828adc7d929
Autor:
Cinthya Aguero, Maeva Dhaynaut, Marc D. Normandin, Ana C. Amaral, Nicolas J. Guehl, Ramesh Neelamegam, Marta Marquie, Keith A. Johnson, Georges El Fakhri, Matthew P. Frosch, Teresa Gomez-Isla
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract [F-18]-MK-6240, a novel tau positron emission tomography (PET) tracer recently discovered for the in vivo detection of neurofibrillary tangles, has the potential to improve diagnostic accuracy in the detection of Alzheimer disease. We have e
Externí odkaz:
https://doaj.org/article/c17455142d6d417a93810cff5500cd94
Autor:
Yang Sun, Nicolas J. Guehl, Yu-Peng Zhou, Kazue Takahashi, Vasily Belov, Maeva Dhaynaut, Sung-Hyun Moon, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas
Publikováno v:
ACS Chemical Neuroscience. 13:3342-3351
Demyelination, the loss of the insulating sheath of neurons, causes failed or slowed neuronal conduction and contributes to the neurological symptoms in multiple sclerosis, traumatic brain and spinal cord injuries, stroke, and dementia. In demyelinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fe0e4ee5fd61ebc5118cd85f17f74d
https://doi.org/10.1021/acschemneuro.2c00364
https://doi.org/10.1021/acschemneuro.2c00364
Autor:
Georges El Fakhri, Normandin, Nicolas Guehl, Maeva Dhaynaut, Sepideh Afshar, Xiying Qu, Sung-Hyun Moon, Gengyang Yuan, Ramesh Neelamegam, Pekka Poutiainen, Anna-Lissa Brownell
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 43:296-308
Metabotropic glutamate receptor 2 (mGluR2) has been extensively studied for the treatment of various neurological and psychiatric disorders. Understanding of the mGluR2 function is pivotal in supporting the drug discovery targeting mGluR2. Herein, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ec040acb2504e3c1cd52ea7aaaa40b
https://doi.org/10.1177/0271678x221130387
https://doi.org/10.1177/0271678x221130387
Autor:
Gengyang, Yuan, Maeva, Dhaynaut, Nicolas J, Guehl, Sepideh, Afshar, Dalena, Huynh, Sung-Hyun, Moon, Suhasini M, Iyengar, Manish Kumar, Jain, Julie E, Pickett, Hye Jin, Kang, Mary Jo, Ondrechen, Georges, El Fakhri, Marc D, Normandin, Anna-Liisa, Brownell
Publikováno v:
Journal of medicinal chemistry. 65(14)
An array of triazolopyridines based on JNJ-46356479 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ecf86dcfbee8ecb3de446d4a3dfa7f3
https://pubmed.ncbi.nlm.nih.gov/35802702
https://pubmed.ncbi.nlm.nih.gov/35802702
Autor:
Gengyang Yuan, Maeva Dhaynaut, Nicolas J. Guehl, Sepideh Afshar, Dalena Huynh, Sung-Hyun Moon, Suhasini M. Iyengar, Manish Kumar Jain, Julie E. Pickett, Hye Jin Kang, Mary Jo Ondrechen, Georges El Fakhri, Marc D. Normandin, Anna-Liisa Brownell
Publikováno v:
Journal of Medicinal Chemistry. 65:9939-9954
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::718a0a41038b3ae055d0f610dab969ad
https://doi.org/10.1021/acs.jmedchem.2c00593
https://doi.org/10.1021/acs.jmedchem.2c00593
Autor:
Yu-Peng Zhou, Moses Q. Wilks, Maeva Dhaynaut, Nicolas J. Guehl, Sung-Hyun Moon, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas
Publikováno v:
bioRxiv
Purpose4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [11C]3MeO4AP has shown promise due to its high brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867454f1f3179ff092083ff081c1b839
https://europepmc.org/articles/PMC10081174/
https://europepmc.org/articles/PMC10081174/
Autor:
Maeva Dhaynaut, Giulia Sprugnoli, Davide Cappon, Joanna Macone, Justin S. Sanchez, Marc D. Normandin, Nicolas J. Guehl, Giacomo Koch, Rachel Paciorek, Ann Connor, Daniel Press, Keith Johnson, Alvaro Pascual-Leone, Georges El Fakhri, Emiliano Santarnecchi
Publikováno v:
Journal of Alzheimer's Disease. 85:1667-1676
Background: Alzheimer’s disease (AD) is characterized by diffuse amyloid-β (Aβ) and phosphorylated Tau (p-Tau) aggregates as well as neuroinflammation. Exogenously-induced 40 Hz gamma oscillations have been showing to reduce Aβ and p-Tau deposit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10e92771e013d872da295a9efcf10951
https://doi.org/10.3233/jad-215072
https://doi.org/10.3233/jad-215072