Sca-1 is a marker for cell plasticity in murine pancreatic epithelial cells and induced by IFN-β in vitro.

Autor: Leinenkugel G; Department of Gastroenterology and Hepatology, University Hospital Zurich, Switzerland. Electronic address: georg.leinenkugel@usz.ch., Kong B; Department of General and Gastrointestinal Surgery, Ulm University Hospital, Ulm, Germany., Raulefs S; Department of Surgery, University Hospital of the Technical University, Munich, Germany., Miller K; Department of Surgery, University Hospital of the Technical University, Munich, Germany., Roth S; Department of Surgery, Heidelberg University Hospital, Heidelberg, Germany., Jiang H; Department of Surgery, Heidelberg University Hospital, Heidelberg, Germany., Istvánffy R; Department of Surgery, University Hospital of the Technical University, Munich, Germany., Heikenwälder H; Department of Surgery, Heidelberg University Hospital, Heidelberg, Germany., Maeritz N; Department of Surgery, University Hospital of the Technical University, Munich, Germany., Regel I; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany., Abiatari I; Institute of Medical and Public Health Research, Ilia State University, Tbilisi, Georgia., Kleeff J; Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Hospital, Halle (Saale), Germany., Michalski CW; Department of General and Gastrointestinal Surgery, Ulm University Hospital, Ulm, Germany., Rieder S; Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Hospital, Halle (Saale), Germany.

Publikováno v: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] [Pancreatology] 2022 Mar; Vol. 22 (2), pp. 294-303. Date of Electronic Publication: 2022 Jan 13.

AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53.

Autor: Zhang Z; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Li H; Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China; Department of Surgery, Ulm University Hospital, Ulm University, Ulm, Germany., Deng Y; Jiangsu Key Laboratory of Neuropsychiatric Diseases, and College of Pharmaceutical Sciences, Soochow University, Suzhou, China., Schuck K; Department of Surgery, Ulm University Hospital, Ulm University, Ulm, Germany., Raulefs S; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Maeritz N; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Yu Y; Department of Surgery, Ulm University Hospital, Ulm University, Ulm, Germany., Hechler T; Heidelberg Pharma Research GmbH, Ladenburg, Germany., Pahl A; Heidelberg Pharma Research GmbH, Ladenburg, Germany., Fernández-Sáiz V; Department of Medicine III, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Center for Translational Cancer Research, Technische Universität München, Munich, Germany., Wan Y; The Pq Laboratory of Micro/Nano BiomeDx, Department of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York., Wang G; The Pq Laboratory of Micro/Nano BiomeDx, Department of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York., Engleitner T; Center for Translational Cancer Research, Technische Universität München, Munich, Germany; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Comprehensive Cancer Center Munich, Technical University of Munich, Munich, Germany., Öllinger R; Center for Translational Cancer Research, Technische Universität München, Munich, Germany; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; German Cancer Consortium at the partner site Munich, Munich, Germany., Rad R; Center for Translational Cancer Research, Technische Universität München, Munich, Germany; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; German Cancer Consortium at the partner site Munich, Munich, Germany., Reichert M; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany., Diakopoulos KN; Comprehensive Cancer Center Munich, Technical University of Munich, Munich, Germany., Weber V; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Li J; Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China., Shen S; Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China., Zou X; Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China., Kleeff J; Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Halle, Germany., Mihaljevic A; Department of Surgery, Ulm University Hospital, Ulm University, Ulm, Germany., Michalski CW; Department of Surgery, Ulm University Hospital, Ulm University, Ulm, Germany., Algül H; Comprehensive Cancer Center Munich, Technical University of Munich, Munich, Germany., Friess H; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Kong B; Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China; Department of Surgery, Ulm University Hospital, Ulm University, Ulm, Germany. Electronic address: bo.kong@uniklinik-ulm.de.

Publikováno v: Gastroenterology [Gastroenterology] 2021 Nov; Vol. 161 (5), pp. 1601-1614.e23. Date of Electronic Publication: 2021 Jul 23.

mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote Kras ^G12D -Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis.

Autor: Zhao Y; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Schoeps B; Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Yao D; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Zhang Z; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Schuck K; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Tissen V; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Jäger C; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Schlitter AM; Institute of Pathology, Technical University of Munich, Munich, Germany., van der Kammen R; Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Ludwig C; Bavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich, Freising, Germany., D'Haese JG; Department of General, Visceral, and Transplantation, Ludwig Maximilians University, Munich, Germany., Raulefs S; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Maeritz N; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Shen S; Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China., Zou X; Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China., Krüger A; Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Kleeff J; Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Germany., Michalski CW; Department of General Surgery, University of Ulm, Ulm, Germany., Friess H; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Innocenti M; Heidelberg University Biochemistry Center, Heidelberg University, Heidelberg, Germany., Kong B; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany; Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China; German Cancer Consortium at the partner site Munich, Munich, Germany. Electronic address: bo.kong@tum.de.

Publikováno v: Gastroenterology [Gastroenterology] 2021 Apr; Vol. 160 (5), pp. 1755-1770.e17. Date of Electronic Publication: 2021 Jan 01.

Differential miRNA and Protein Expression Reveals miR-1285, Its Targets TGM2 and CDH-1, as Well as CD166 and S100A13 as Potential New Biomarkers in Patients with Diabetes Mellitus and Pancreatic Adenocarcinoma.

Autor: Kolokotronis, Theodoros^1,2 (AUTHOR) britta.majchrzak-stiller@ruhr-uni-bochum.de, Majchrzak-Stiller, Britta¹ (AUTHOR) marie.buchholz-a7y@rub.de, Buchholz, Marie¹ (AUTHOR) vanessa.mense@studmail.w-hs.de, Mense, Vanessa¹ (AUTHOR) johanna.strotmann@ruhr-uni-bochum.de, Strotmann, Johanna¹ (AUTHOR) ilka.peters@rub.de, Peters, Ilka¹ (AUTHOR) lea.skrzypczyk@klinikum-bochum.de, Skrzypczyk, Lea¹ (AUTHOR) waldemar.uhl@ruhr-uni-bochum.de, Liffers, Sven-Thorsten³ (AUTHOR) sven-thorsten.liffers@uk-essen.de, Menkene, Louise Massia² (AUTHOR) mathias.wagner@uks.eu, Wagner, Mathias² (AUTHOR), Glanemann, Matthias² (AUTHOR), Betsou, Fay⁴ (AUTHOR) fay.betsou@pasteur.fr, Ammerlaan, Wim⁵ (AUTHOR) wim.ammerlaan@ibbl.lu, Schmidt, Ronny⁶ (AUTHOR) ronny.schmidt@sciomics.de, Schröder, Christoph⁶ (AUTHOR) christoph.schroeder@sciomics.de, Uhl, Waldemar¹ (AUTHOR) chris.braumann@evk-ge.de, Braumann, Chris^1,7 (AUTHOR) philipp.hohn@ruhr-uni-bochum.de, Höhn, Philipp¹ (AUTHOR)

Publikováno v: Cancers. Aug2024, Vol. 16 Issue 15, p2726. 24p.

Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma.

Autor: Jian Z; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Cheng T; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Zhang Z; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Raulefs S; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Shi K; Department of Nuclear Medicine, TUM, Munich, Germany., Steiger K; Institute of Pathology, TUM, Munich, Germany., Maeritz N; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Kleigrewe K; Bavarian Center for Biomolecular Mass Spectrometry, Freising, Germany., Hofmann T; Bavarian Center for Biomolecular Mass Spectrometry, Freising, Germany., Benitz S; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.; Medizinische Klinik und Poliklinik II, Klinikum der LMU, Munich, Germany., Bruns P; Division of Applied Bioinformatics, German Cancer Research Center, Heidelberg, Germany., Lamp D; Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research, Helmholtz Zentrum München, Neuherberg, Germany.; Division of Metabolic Diseases, TUM, Munich, Germany., Jastroch M; Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research, Helmholtz Zentrum München, Neuherberg, Germany., Akkan J; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Jäger C; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Huang P; Department of Pathology, School of Medicine, Southeast University, Nanjing, China., Nie S; Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China., Shen S; Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China., Zou X; Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China., Ceyhan GO; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Michalski CW; Department of Visceral, Vascular and Endocrine Surgery, Martin-Luther-University Halle-Wittenberg, Halle, Germany., Friess H; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany., Kleeff J; Department of Visceral, Vascular and Endocrine Surgery, Martin-Luther-University Halle-Wittenberg, Halle, Germany., Kong B; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.; Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China.; German Cancer Consortium (DKTK) at the partner site Munich, Munich, Germany.

Publikováno v: Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2018 Jul 26; Vol. 6 (4), pp. 429-449. Date of Electronic Publication: 2018 Jul 26 (Print Publication: 2018).