Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Maelle Duffey"'
Autor:
Oriana Kreutzfeld, Patrick K. Tumwebaze, Martin Okitwi, Stephen Orena, Oswald Byaruhanga, Thomas Katairo, Melissa D. Conrad, Stephanie A. Rasmussen, Jennifer Legac, Ozkan Aydemir, David Giesbrecht, Barbara Forte, Peter Campbell, Alasdair Smith, Hiroki Kano, Samuel L. Nsobya, Benjamin Blasco, Maelle Duffey, Jeffrey A. Bailey, Roland A. Cooper, Philip J. Rosenthal
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Malaria, especially Plasmodium falciparum infection, remains an enormous problem, and its treatment and control are seriously challenged by drug resistance. New antimalarial drugs are needed. To characterize the Medicines for Malaria Venture
Externí odkaz:
https://doaj.org/article/373b8efbdb7d4e76aea7095c81c6a1bf
Autor:
Shreeya Garg, Oriana Kreutzfeld, Sevil Chelebieva, Patrick K. Tumwebaze, Oswald Byaruhanga, Martin Okitwi, Stephen Orena, Thomas Katairo, Samuel L. Nsobya, Melissa D. Conrad, Ozkan Aydemir, Jennifer Legac, Alexandra E. Gould, Brett R. Bayles, Jeffrey A. Bailey, Maelle Duffey, Gang Lin, Laura A. Kirkman, Roland A. Cooper, Philip J. Rosenthal
Publikováno v:
Antimicrobial agents and chemotherapy, vol 66, iss 10
Antimicrob Agents Chemother
Antimicrob Agents Chemother
The proteasome is a promising target for antimalarial chemotherapy. We assessed ex vivo susceptibilities of fresh Plasmodium falciparum isolates from eastern Uganda to seven proteasome inhibitors: two asparagine ethylenediamines, two macrocyclic pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68bc34406b4545749259203028861266
https://escholarship.org/uc/item/8dm1n152
https://escholarship.org/uc/item/8dm1n152
Autor:
Selina Bopp, Charisse Flerida A. Pasaje, Robert L. Summers, Pamela Magistrado-Coxen, Kyra A. Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S. Nasamu, Allison R. Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M. Early, Amanda K. Lukens, Danny Milner, Jeremy Furtado, Francisco-Javier Gamo, Elizabeth A. Winzeler, Sarah K. Volkman, Maëlle Duffey, Benoît Laleu, David A. Fidock, Susan Wyllie, Jacquin C. Niles, Dyann F. Wirth
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Drug resistance to current antimalarials is rising and new drugs and targets are urgently needed. Here the authors identify Plasmodium falciparum acyl-CoA synthetase 10 as a new target whose inhibition leads to a decrease in triacylglycerols.
Externí odkaz:
https://doaj.org/article/8ae40ec50bdc468aaa960a15e9ca87b3
Autor:
Koen J. Dechering, Martijn Timmerman, Kim Rensen, Karin M.J. Koolen, Saman Honarnejad, Martijn W. Vos, Tonnie Huijs, Rob W.M. Henderson, Elodie Chenu, Benoît Laleu, Bailey C. Montefiore, Matthew D. Segall, James E.J. Mills, Eric M. Guantai, James Duffy, Maëlle Duffey
Publikováno v:
SLAS Discovery, Vol 27, Iss 6, Pp 337-348 (2022)
A central challenge of antimalarial therapy is the emergence of resistance to the components of artemisinin-based combination therapies (ACTs) and the urgent need for new drugs acting through novel mechanism of action. Over the last decade, compounds
Externí odkaz:
https://doaj.org/article/5462a223647e4fcf83104fa393c505f1
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 5-11 (2021)
Several promising antimalarial drugs are currently being tested in human trials, such as artefenomel, cipargamin, ferroquine and ganaplacide. Many of these compounds were identified using high throughput screens against a single species of human mala
Externí odkaz:
https://doaj.org/article/09e01d952bcc4d1799218527c8849190
Autor:
Annabelle Walz, Maëlle Duffey, Ghaith Aljayyoussi, Sibylle Sax, Didier Leroy, Dominique Besson, Jeremy N. Burrows, Mohammed H. Cherkaoui-Rbati, Nathalie Gobeau, Marie-Anne Westwood, Christoph Siethoff, Francisco-Javier Gamo, Pascal Mäser, Sergio Wittlin
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 163 (2023)
With artemisinin-resistant Plasmodium falciparum parasites emerging in Africa, the need for new antimalarial chemotypes is persistently high. The ideal pharmacodynamic parameters of a candidate drug are a rapid onset of action and a fast rate of para
Externí odkaz:
https://doaj.org/article/ed61e47142b2471096b9a830abacea17
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-10 (2018)
Abstract Background The increased resistance of the human malaria parasite Plasmodium falciparum to currently employed drugs creates an urgent call for novel anti-malarial drugs. Particularly, efforts should be devoted to developing fast-acting anti-
Externí odkaz:
https://doaj.org/article/c48dd7650b764c84aeefe40a13aad424
Autor:
Stefano Pegoraro, Maëlle Duffey, Thomas D Otto, Yulin Wang, Roman Rösemann, Roland Baumgartner, Stefanie K Fehler, Leonardo Lucantoni, Vicky M Avery, Alicia Moreno-Sabater, Dominique Mazier, Henri J Vial, Stefan Strobl, Cecilia P Sanchez, Michael Lanzer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Severe malaria is a life-threatening infection with limited treatment options. Here, using a medicinal chemistry approach starting from amicarbalide, Pegoraroet al. identify a compound that, when delivered intravenously, can cure Plasmodium falciparu
Externí odkaz:
https://doaj.org/article/31209cc459aa4f289ae53a99dad149ad
Autor:
Stefano Pegoraro, Maëlle Duffey, Thomas D. Otto, Yulin Wang, Roman Rösemann, Roland Baumgartner, Stefanie K. Fehler, Leonardo Lucantoni, Vicky M. Avery, Alicia Moreno-Sabater, Dominique Mazier, Henri J. Vial, Stefan Strobl, Cecilia P. Sanchez, Michael Lanzer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-2 (2017)
Nature Communications 8 Article number:14193 (2017); Published 31 January 2017; Updated 6 Apr 2017 This Article contains errors in Figs. 1 and 8 that were introduced during the production process. The compound on the lower right side of Fig. 1 is lab
Externí odkaz:
https://doaj.org/article/65a3e0ea84b44bb1b074722eba24c8d6