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Assessing in vivo mutation frequencies and creating a high-resolution genome-wide map of fitness costs of Hepatitis C virus.

Autor: Kaho H Tisthammer, Caroline Solis, Faye Orcales, Madu Nzerem, Ryan Winstead, Weiyan Dong, Jeffrey B Joy, Pleuni S Pennings

Publikováno v: PLoS Genetics, Vol 18, Iss 5, p e1010179 (2022)

Like many viruses, Hepatitis C Virus (HCV) has a high mutation rate, which helps the virus adapt quickly, but mutations come with fitness costs. Fitness costs can be studied by different approaches, such as experimental or frequency-based approaches.

Externí odkaz: https://doaj.org/article/b5e2d0b3c4bc4345896f48e4d4449ef2

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Assessingin vivomutation frequencies and creating a high-resolution genome-wide map of fitness costs of Hepatitis C virus

Autor: Kaho H. Tisthammer, Caroline Solis, Faye Oracles, Madu Nzerem, Ryan Winstead, Weiyan Dong, Jeffrey B. Joy, Pleuni S. Pennings

Studying in vivo fitness costs of mutations in viruses provides important insights into their evolutionary dynamics, which can help decipher how they adapt to host immune systems and develop drug resistance. However, studying fitness costs in natural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4d55cbac2d59c75076f006700ff1271
https://doi.org/10.1101/2020.10.01.323253

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