Incorporation of β-Silicon-β3-Amino Acids in the Antimicrobial Peptide Alamethicin Provides a 20-Fold Increase in Membrane Permeabilization.

Autor: Madsen, Julie L. H.¹, Hjørringgaard, Claudia U.¹, Vad, Brian S.², Otzen, Daniel² dao@inano.au.dk, Skrydstrup, Troels¹ ts@chem.au.dk

Publikováno v: Chemistry - A European Journal. 6/6/2016, Vol. 22 Issue 24, p8358-8367. 10p.

Chemical Modifications of Peptides and Evaluation of the Resulting Bioactivity:Incorporation of Silicon to Afford Selective HNE Inhibitors and Improve Antimicrobial Activity of Alamethicin - Towards a Bioorthogonal ROMP Reaction for in situ Conjugation of Alamethicin Pores

Autor: Madsen, Julie L H

Publikováno v: Madsen, J L H 2013, Chemical Modifications of Peptides and Evaluation of the Resulting Bioactivity : Incorporation of Silicon to Afford Selective HNE Inhibitors and Improve Antimicrobial Activity of Alamethicin-Towards a Bioorthogonal ROMP Reaction for in situ Conjugation of Alamethicin Pores .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::704119874db902b21368d65f1c03aec5
https://pure.au.dk/portal/da/publications/chemical-modifications-of-peptides-and-evaluation-of-the-resulting-bioactivity(28c844e7-835d-4558-9cce-8e8beaab05bf).html

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Synthesis and Evaluationof Silanediols as HighlySelective Uncompetitive Inhibitors of Human Neutrophil Elastase.

Autor: Madsen, Julie L. H., Andersen, Thomas L., Santamaria, Salvatore, Nagase, Hideaki, Enghild, Jan J., Skrydstrup, Troels

Publikováno v: Journal of Medicinal Chemistry; Sep2012, Vol. 55 Issue 17, p7900-7908, 9p