Sequence-targeted Peptides Divert Functional Bacterial Amyloid Towards Destabilized Aggregates and Reduce Biofilm Formation

Autor: Sønderby, Thorbjørn V, Louros, Nikolaos N, Khodaparast, Ladan, Khodaparast, Laleh, Madsen, Daniel J, Olsen, William P, Moonen, Nele, Nagaraj, Madhu, Sereikaite, Vita, Strømgaard, Kristian, Rousseau, Frederic, Schymkowitz, Joost, Otzen, Daniel E

Publikováno v: Sønderby, T V, Louros, N N, Khodaparast, L, Khodaparast, L, Madsen, D J, Olsen, W P, Moonen, N, Nagaraj, M, Sereikaite, V, Strømgaard, K, Rousseau, F, Schymkowitz, J & Otzen, D E 2023, ' Sequence-targeted Peptides Divert Functional Bacterial Amyloid Towards Destabilized Aggregates and Reduce Biofilm Formation ', Journal of Molecular Biology, pp. 168039 . https://doi.org/10.1016/j.jmb.2023.168039

Functional bacterial amyloid provides structural stability in biofilm, making it a promising target for anti-biofilm therapeutics. Fibrils formed by CsgA, the major amyloid component in E. coli are extremely robust and can withstand very harsh condit

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https://lirias.kuleuven.be/handle/20.500.12942/721227