WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport

Autor: Bidisha Saha, Deise C. A. Leite-Dellova, John Demko, Mads Vaarby Sørensen, Enzo Takagi, Catherine E. Gleason, Waheed Shabbir, David Pearce

Publikováno v: Saha, B, Leite-Dellova, D C A, Demko, J, Sørensen, M V, Takagi, E, Gleason, C E, Shabbir, W & Pearce, D 2022, ' WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport ', Journal of cell science, vol. 135, no. 23 . https://doi.org/10.1242/jcs.260313
Sørensen, M V 2022, ' WNK1 is a chloride-stimulated scaffold that regulates mTORC2-activity and ion transport ', Journal of Cell Science . https://doi.org/10.1242/jcs.260313

Mammalian (or mechanistic) target of rapamycin complex 2 (mTORC2) is a kinase complex that targets predominantly Akt family proteins, SGK1 and protein kinase C (PKC), and has well-characterized roles in mediating hormone and growth factor effects on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006d236944f1659efab2fc749df97d8e
https://pure.au.dk/portal/da/publications/wnk1-is-a-chloridestimulated-scaffold-that-regulates-mtorc2-activity-and-ion-transport(9c8ebebb-8bdf-4b00-92ed-ba72d8c3ec66).html

Alkalosis-induced hypoventilation in cystic fibrosis:The importance of efficient renal adaptation

Autor: Peder Berg, Jesper Frank Andersen, Mads Vaarby Sørensen, Tobias Wang, Hans Malte, Jens Leipziger

Publikováno v: Berg, P, Andersen, J F, Sørensen, M V, Wang, T, Malte, H & Leipziger, J 2022, ' Alkalosis-induced hypoventilation in cystic fibrosis : The importance of efficient renal adaptation ', PNAS (Proceedings of the National Academy of Sciences of the United States of America), bind 119, nr. 8, e2116836119 . https://doi.org/10.1073/pnas.2116836119

Significance statement: In conditions when our blood experiences alkalosis, a pronounced kidney response is initiated causing a marked increase of urine base excretion. We recently discovered the cellular physiology of this, which employs fast activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb3e7bdfca09e25ae9f8461001715d8
https://pure.au.dk/portal/da/publications/alkalosisinduced-hypoventilation-in-cystic-fibrosis(d2e6f349-e709-4f46-b036-72aaafc57ae0).html

The Cystic Fibrosis Urine Test

Autor: Peder Berg, Svendsen, Samuel Levi Svinth C., Mads Vaarby Sørensen, Søren Jensen-Fangel, Majbritt Jeppesen, Karl Kunzelmann, Jens Georg Leipziger

Publikováno v: Berg, P, Svendsen, S L S C, Sørensen, M V, Jensen-Fangel, S, Jeppesen, M, Kunzelmann, K & Leipziger, J G 2019, ' The Cystic Fibrosis Urine Test ', American Society of Nephrology-Kidney Week 2019, Washington DC, United States, 07/11/2019-10/11/2019 . < https://www.asn-online.org/education/kidneyweek/2019/program-abstract.aspx?controlId=3234422 >
Aarhus University

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6a4b42655a1a7e938fddf306b628181a
https://pure.au.dk/portal/da/publications/the-cystic-fibrosis-urine-test(81fe45bb-bc18-4570-aeb9-9b201cd10b96).html

Adrenaline-induced colonic K+ secretion is mediated by KCa1.1 (BK) channels

Autor: Mads Vaarby Sørensen, Matthias Sausbier, Peter Ruth, Ursula Seidler, Brigitte Riederer, Helle Praetorius, Jens Georg Leipziger

Publikováno v: Aarhus University

Colonic epithelial K(+) secretion is a two-step transport process with initial K(+) uptake over the basolateral membrane followed by K(+) channel-dependent exit into the lumen. In this process the large-conductance, Ca(2+)-activated K(Ca)1.1 (BK) cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::44d0b595757e6be600c6cb63cca834b1
http://pure.au.dk/portal/en/publications/adrenalineinduced-colonic-k-secretion-is-mediated-by-kca11-bk-channels(92dcc9b0-746b-11df-8c1a-000ea68e967b).html