Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mads V. Sorensen"'
Autor:
Peder Berg, Mads V. Sorensen, Amalie Quist Rousing, Hanne Vebert Olesen, Søren Jensen-Fangel, Majbritt Jeppesen, Jens Leipziger
Publikováno v:
Berg, P, Sorensen, M V, Rousing, A Q, Olesen, H V, Jensen-Fangel, S, Jeppesen, M & Leipziger, J 2022, ' Challenged Urine Bicarbonate Excretion as a Measure of Cystic Fibrosis Transmembrane Conductance Regulator Function in Cystic Fibrosis ', Annals of Internal Medicine, vol. 175, no. 11, pp. 1543-1551 . https://doi.org/10.7326/M22-1741
BACKGROUND: In cystic fibrosis (CF), renal base excretion is impaired. Accordingly, challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis transmembrane conductance regulator (CFTR) function.OBJECTIVE: To evaluate the a
Autor:
Jesper Frank Andersen, Charles S. Wingo, Jens Leipziger, Niklas Ayasse, I. Jeanette Lynch, Natalya U. Fedosova, Samuel L Svendsen, Mads V. Sorensen, Peder Berg
Publikováno v:
Ayasse, N, Berg, P, Andersen, J F, Svendsen, S L S C, Sørensen, M V, Fedosova, N, Wingo, C, Lynch, I J & Leipziger, J G 2021, ' Benzamil-mediated urine alkalization is caused by the inhibition of H +, K + ATPases ', American Journal of Physiology: Renal Physiology, vol. 320, no. 4, pp. F596-F607 . https://doi.org/10.1152/ajprenal.00444.2020
Epithelial Na+ channel (ENaC) blockers elicit acute and substantial increases of urinary pH. The underlying mechanism remains to be understood. Here, we evaluated if benzamil-induced urine alkalization is mediated by an acute reduction in H+ secretio
Autor:
Jeppe Olsen, Vladimir V. Matchkov, Mads V. Sorensen, Ebbe Boedtkjer, Peder Berg, Vibeke Secher Dam, Samuel L Svendsen, Jens Leipziger
Publikováno v:
Olsen, J S, Svendsen, S L S C, Berg, P, Dam, V S, Sørensen, M V, Matchkov, V, Leipziger, J G & Boedtkjer, E 2021, ' NBCn1 increases NH 4 + reabsorption across thick ascending limbs, the capacity for urinary NH 4 + excretion, and early recovery from metabolic acidosis ', Journal of the American Society of Nephrology, vol. 32, no. 4, pp. 852-865 . https://doi.org/10.1681/ASN.2019060613
BACKGROUND: The electroneutral Na +/HCO 3 - cotransporter NBCn1 (Slc4a7) is expressed in basolateral membranes of renal medullary thick ascending limbs (mTALs). However, direct evidence that NBCn1 contributes to acid-base handling in mTALs, urinary n
Autor:
Samuel L Svendsen, Rainer Schreiber, Mads V. Sorensen, Jens Leipziger, Karl Kunzelmann, Peder Berg
Publikováno v:
Berg, P, Svendsen, S L, Sorensen, M V, Schreiber, R, Kunzelmann, K & Leipziger, J 2021, ' The molecular mechanism of CFTR-and secretin-dependent renal bicarbonate excretion ', The Journal of Physiology, vol. 599, no. 12, pp. 3003-3011 . https://doi.org/10.1113/JP281285
This review summarizes the newly discovered molecular mechanism of secretin-stimulated urine HCO3- excretion and the role of CFTR in renal HCO3- excretion. The secretin receptor is functionally expressed in the basolateral membrane of the HCO3- secre
Publikováno v:
Ayasse, N, Berg, P, Leipziger, J G & Sørensen, M V 2021, ' ENaC expression correlates with the acute furosemide-induced K + excretion ', Physiological Reports, vol. 9, no. 1 . https://doi.org/10.14814/phy2.14668
Background: In the aldosterone-sensitive distal nephron (ASDN), epithelial sodiumchannel (ENaC)-mediated Na+ absorption drives K+ excretion. K+ excretion dependson the delivery of Na+ to the ASDN and molecularly activated ENaC. Furosemideis known as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d59deb595aabce52e03c231c1017a5
https://pure.au.dk/ws/files/207147678/final_paper.pdf
https://pure.au.dk/ws/files/207147678/final_paper.pdf
Autor:
Helle A. Praetorius, Samuel L Svendsen, Mads V. Sorensen, Thi Thuy Linh Hoang, Peder Berg, Jens Leipziger
Publikováno v:
Berg, P, Svendsen, S L, Hoang, T T L, Praetorius, H A, Sørensen, M V & Leipziger, J 2021, ' Impaired renal HCO 3-secretion in CFTR deficient mice causes metabolic alkalosis during chronic base-loading ', Acta Physiologica, vol. 231, no. 3, e13591 . https://doi.org/10.1111/apha.13591
Aim: Cystic fibrosis patients have an increased risk of developing metabolic alkalosis presumably as a result of altered renal HCO3- handling. In this study, we directly assess the kidneys’ ability to compensate for a chronic base-load in the absen
Autor:
Jeppe S M, Olsen, Samuel, Svendsen, Peder, Berg, Vibeke S, Dam, Mads V, Sorensen, Vladimir V, Matchkov, Jens, Leipziger, Ebbe, Boedtkjer
Publikováno v:
J Am Soc Nephrol
BACKGROUND: The electroneutral Na(+)/HCO(3)(−) cotransporter NBCn1 (Slc4a7) is expressed in basolateral membranes of renal medullary thick ascending limbs (mTALs). However, direct evidence that NBCn1 contributes to acid-base handling in mTALs, urin
Autor:
Peder, Berg, Samuel L, Svendsen, Thi Thuy Linh, Hoang, Helle A, Praetorius, Mads V, Sorensen, Jens, Leipziger
Publikováno v:
Acta physiologica (Oxford, England)REFERENCES. 231(3)
Cystic fibrosis patients have an increased risk of developing metabolic alkalosis presumably as a result of altered renal HCOComprehensive urine and blood acid-base analyses were done in anaesthetized WT mice or mice lacking either CFTR or pendrin, w
Autor:
Rainer Schreiber, Jens Leipziger, Majbritt Jeppesen, Jesper Frank Andersen, Karl Kunzelmann, Inês Cabrita, Samuel L Svendsen, Mads V. Sorensen, Søren Jensen-Fangel, Peder Berg, Casper Larsen
Publikováno v:
J Am Soc Nephrol
Berg, P, Svendsen, S L S C, Sørensen, M V, Larsen, C K, Andersen, J F, Jensen-Fangel, S, Jeppesen, M, Schreiber, R, Cabrita, I, Kunzelmann, K & Leipziger, J G 2020, ' Impaired Renal HCO3-Excretion in Cystic Fibrosis ', Journal of the American Society of Nephrology, vol. 31, no. 8, 31, pp. 1711-1727 . https://doi.org/10.1681/ASN.2020010053
Berg, P, Svendsen, S L S C, Sørensen, M V, Larsen, C K, Andersen, J F, Jensen-Fangel, S, Jeppesen, M, Schreiber, R, Cabrita, I, Kunzelmann, K & Leipziger, J G 2020, ' Impaired Renal HCO3-Excretion in Cystic Fibrosis ', Journal of the American Society of Nephrology, vol. 31, no. 8, 31, pp. 1711-1727 . https://doi.org/10.1681/ASN.2020010053
BACKGROUND: Patients with cystic fibrosis (CF) do not respond with increased urinary HCO(3)(−) excretion after stimulation with secretin and often present with metabolic alkalosis. METHODS: By combining RT-PCR, immunohistochemistry, isolated tubule
Autor:
David A. Pearce, Peng Wu, Iben Skov Jensen, Wen-Hui Wang, Bidisha Saha, Catherine E. Gleason, Samuel L Svendsen, Mads V. Sorensen, Niklas Ayasse
Publikováno v:
Sørensen, M V, Saha, B, Jensen, I S, Wu, P, Ayasse, N, Gleason, C E, Svendsen, S L, Wang, W H & Pearce, D 2019, ' Potassium acts through mTOR to regulate its own secretion ', JCI Insight, vol. 4, no. 11, e126910 . https://doi.org/10.1172/jci.insight.126910
JCI insight, vol 5, iss 11
JCI insight, vol 5, iss 11
Potassium (K+) secretion by kidney tubule cells is central to electrolyte homeostasis in mammals. In the K+-secreting principal cells of the distal nephron, electrogenic Na+ transport by the epithelial sodium channel (ENaC) generates the electrical d