Predictors of Response to Biologics in Patients with Moderate-to-severe Psoriasis: A Danish Nationwide Cohort Study

Autor: Christopher Willy Schwarz, Nikolai Loft, Mads Kirchheiner Rasmussen, Christoffer V. Nissen, Tomas Norman Dam, Kawa Khaled Ajgeiy, Alexander Egeberg, Lone Skov

Publikováno v: Acta Dermato-Venereologica, Vol 101, Iss 10 (2021)

Identifying patient characteristics associated with achieving treatment response to biologics in patients with psoriasis could prevent expensive switching between biologics. The aim of this study was to identify patient characteristics that predict t

Externí odkaz: https://doaj.org/article/8fb70ddb11d549009a13c7c93b270c5c

Response to Biologics During the First Six Months of Therapy in Biologic-naïve Patients with Psoriasis Predicts Risk of Disease Flares: A Danish Nationwide Study

Autor: Nikolai Loft, Alexander Egeberg, Mads Kirchheiner Rasmussen, Lars Erik Bryld, Christoffer V. Nissen, Tomas Norman Dam, Kawa Khaled Ajgeiy, Lars Iversen, Lone Skov

Publikováno v: Acta Dermato-Venereologica, Vol 101, Iss 1, p adv00357 (2021)

Early response to treatment with biologics might be important for the stability of psoriasis and long-term outcome. The aim of this study was therefore to assess whether risk of flares and drug survival are associated with disease activity in the fir

Externí odkaz: https://doaj.org/article/e7675e3c327f4c898f3aa9416c03fb34

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Autor: Jacob Lauwring Andersen, Borbala Gesser, Erik Daa Funder, Christine Juul Fælled Nielsen, Helle Gotfred-Rasmussen, Mads Kirchheiner Rasmussen, Rachel Toth, Kurt Vesterager Gothelf, J. Simon C. Arthur, Lars Iversen, Poul Nissen

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)

Dimethyl fumarate (DMF) is a major drug in the treatment of psoriasis and multiple sclerosis. Here the authors reveal a mechanism of RSK/MSK inhibition through covalent inhibition that can explain the observed clinical effects and the dose–response

Externí odkaz: https://doaj.org/article/ce38a48876bc4d9fb74081c34943de76

Incidence, Risk Factors, and Consequences of Human Alphaherpesvirus Infections in Patients With Psoriasis Who Initiate Methotrexate or Biologic Agents

Autor: Omid Rezahosseini, Mie Sylow Liljendahl, Nikolai Loft, Dina Leth Møller, Zitta Barrella Harboe, Mads Kirchheiner Rasmussen, Kawa Khaled Ajgeiy, Alexander Egeberg, Lone Skov, Susanne Dam Nielsen

Publikováno v: Rezahosseini, O, Liljendahl, M S, Loft, N, Møller, D L, Harboe, Z B, Rasmussen, M K, Ajgeiy, K K, Egeberg, A, Skov, L & Nielsen, S D 2022, ' Incidence, Risk Factors, and Consequences of Human Alphaherpesvirus Infections in Patients With Psoriasis Who Initiate Methotrexate or Biologic Agents ', The Journal of Infectious Diseases, vol. 226, no. 9, pp. 1510-1518 . https://doi.org/10.1093/infdis/jiac367

Background Immunosuppressive agents may increase the risk of infections with human alphaherpesviruses. Methods We included all adult patients with moderate to severe psoriasis who initiated methotrexate (MTX) or biologic agents in a retrospective coh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4effa2df0968e8b7d62a8ba0f9c0f6c
https://pure.au.dk/portal/da/publications/incidence-risk-factors-and-consequences-of-human-alphaherpesvirus-infections-in-patients-with-psoriasis-who-initiate-methotrexate-or-biologic-agents(b5fc0165-f510-4f67-834d-74987d91ef6e).html

Multivariable Predictive Models to Identify the Optimal Biologic Therapy for Treatment of Patients With Psoriasis at the Individual Level

Autor: Mia-Louise Nielsen, Troels Christian Petersen, Julia-Tatjana Maul, Jashin J. Wu, Mads Kirchheiner Rasmussen, Trine Bertelsen, Kawa Khaled Ajgeiy, Lone Skov, Simon Francis Thomsen, Jacob P. Thyssen, Alexander Egeberg

Publikováno v: Nielsen, M-L, Petersen, T C, Maul, J-T, Wu, J J, Rasmussen, M K, Bertelsen, T, Ajgeiy, K K, Skov, L, Thomsen, S F, Thyssen, J P & Egeberg, A 2022, ' Multivariable Predictive Models to Identify the Optimal Biologic Therapy for Treatment of Patients With Psoriasis at the Individual Level ', JAMA Dermatology, vol. 158, no. 10, pp. 1149-1156 . https://doi.org/10.1001/jamadermatol.2022.3171

ImportanceIdentifying the optimal long-term biologic therapy for patients with psoriasis is often done through trial and error.ObjectiveTo identify the optimal biologic therapy for individual patients with psoriasis using predictive statistical and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5eab4dcf6828b0894557d417ce2bcf
https://pure.au.dk/portal/da/publications/multivariable-predictive-models-to-identify-the-optimal-biologic-therapy-for-treatment-of-patients-with-psoriasis-at-the-individual-level(66fecd37-919e-491a-ae3b-7c48572bad2c).html